Issue 41, 2010
From the journal:

Chemical Communications

Structure–activity relationships of the phosphonateantibiotic dehydrophos†‡

Michael Kueminab  and  Wilfred A. van der Donk*ab  

* Corresponding authors

a Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL, USA
E-mail: vddonk@illinois.edu
Fax: +1 217 244 8533
Tel: +1 217 244 5360

b Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, USA.

Abstract

Synthetic derivatives of the phosphonate antibiotic dehydrophos were tested for antimicrobial activity. Both the phosphonate monomethyl ester and the vinyl phosphonate moiety proved to be important for bacteriocidal activity of the natural product.

Graphical abstract: Structure–activity relationships of the phosphonate antibiotic dehydrophos

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Article information

DOI
https://doi.org/10.1039/C0CC02958K
Article type
Communication
Submitted
01 Aug. 2010
Accepted
02 Sept. 2010
First published
27 Sept. 2010

Chem. Commun., 2010,46, 7694-7696

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Structure–activity relationships of the phosphonate antibiotic dehydrophos

M. Kuemin and W. A. van der Donk, Chem. Commun., 2010, 46, 7694 DOI: 10.1039/C0CC02958K

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