Peroxoniobium inhibits leukemia cell growth

Elene C. Pereira-Maia; Ivina P. Souza; Kelen J. R. C. Nunes; Alexandre A. Castro; Teodorico C. Ramalho; Fernando Steffler; Helio A. Duarte; Ana Pacheli; Poliana Chagas; Luiz C. A. Oliveira

doi:10.1039/C8RA00898A

Peroxoniobium inhibits leukemia cell growth†

Elene C. Pereira-Maia,*^a Ivina P. Souza,‡^a Kelen J. R. C. Nunes,‡^a Alexandre A. Castro,‡^b Teodorico C. Ramalho,

‡^b Fernando Steffler,^a Helio A. Duarte,

^a Ana Pacheli,

‡^a Poliana Chagas ‡^a and Luiz C. A. Oliveira*^a

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* Corresponding authors

^a Universidade Federal de Minas Gerais, Department of Chemistry, Av. Antonio Carlos 6627, Belo Horizonte, MG, Brazil
E-mail: elene@qui.ufmg.br, lcao.ufmg@gmail.com

^b Universidade Federal de Lavras, Department of Chemistry, Lavras, MG, Brazil

Abstract

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC₅₀ value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.

This article is part of the themed collection: Editors’ collection: Photodynamic therapy

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Peroxoniobium inhibits leukemia cell growth†

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