Issue 76, 2024
From the journal:

Chemical Communications

A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP†

Valentyn Pozhydaiev,a   Daniella Al-Othman,a   Joseph Moran ORCID logo *abc  and  David Lebœuf ORCID logo *a  

* Corresponding authors

a Institut de Science et d’Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 67000 Strasbourg, France
E-mail: moran@unistra.fr, dleboeuf@unistra.fr

b Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada

c Institut Universitaire de France (IUF), 75005 Paris, France

Abstract

Here, we report the synthesis of tetrahydroquinolines between newly developed N-benzylhydroxylamine reagents and alkenes using HFIP as a solvent. This transformation is notably applicable to highly electronically deactivated styrenes and aliphatic alkenes, expanding the range of tetrahydroquinolines attainable.

Graphical abstract: A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP

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Article information

DOI
https://doi.org/10.1039/D4CC04014G
Article type
Communication
Submitted
07 Aug. 2024
Accepted
02 Sept. 2024
First published
02 Sept. 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 10504-10507

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A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP

V. Pozhydaiev, D. Al-Othman, J. Moran and D. Lebœuf, Chem. Commun., 2024, 60, 10504 DOI: 10.1039/D4CC04014G

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