Issue 42, 2010
From the journal:

Chemical Communications

Cyclen-hybrid compound captures copper to protect INS-1cells from islet amyloidpolypeptide cytotoxicity by inhibiting and lysing effects†‡

Jia Hu,§a   Ye-Ping Yu,§a   Wei Cui,a   Chuan-Lin Fang,a   Wei-Hui Wu,a   Yu-Fen Zhaoa  and  Yan-Mei Li*a  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: liym@mail.tsinghua.edu.cn
Fax: +86 10 6278 1695
Tel: +86 10 6279 6197

Abstract

Human islet amyloid polypeptide (hIAPP) deposit is the hallmark of type 2 diabetes pathology. Here, we report that apo-cyclen, attached to a specific hIAPP recognition motif (NYGAIL), captured copper ions and became proteolytically active. This cyclen-NYGAIL-copper complex was able to interfere with hIAPP aggregation and cleave hIAPP. These activities rescued INS-1 cells from hIAPP induced cytotoxicity.

Graphical abstract: Cyclen-hybrid compound captures copper to protect INS-1 cells from islet amyloid polypeptide cytotoxicity by inhibiting and lysing effects

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Article information

DOI
https://doi.org/10.1039/C0CC02555K
Article type
Communication
Submitted
14 Jūl. 2010
Accepted
02 Sept. 2010
First published
21 Sept. 2010

Chem. Commun., 2010,46, 8023-8025

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Cyclen-hybrid compound captures copper to protect INS-1 cells from islet amyloid polypeptide cytotoxicity by inhibiting and lysing effects

J. Hu, Y. Yu, W. Cui, C. Fang, W. Wu, Y. Zhao and Y. Li, Chem. Commun., 2010, 46, 8023 DOI: 10.1039/C0CC02555K

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