Synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones using trichloroisocyanuric acid (TCCA): a sustainable approach†
José S. S.
Neto, 
b
Sumbal
Saba,
b
Jamal
Rafique,
*bc
Antonio L.
Braga
*a
and
Francisco F.
de Assis
*a
b
Sumbal
Saba,
b
Jamal
Rafique,
*bc
Antonio L.
Braga
*a
and
Francisco F.
de Assis
*a
Abstract
We hereby present an original and sustainable synthetic methodology for the synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones and diorganoyl diselenides. The reaction is promoted in a one-pot manner by the greener reagent trichloroisocyanuric acid and employs ethanol as a solvent under mild conditions. Using this protocol, 22 examples of 3-selanyl-isoflavones were prepared in 34%–95% yields.
- This article is part of the themed collection: 50th anniversary of ICCST: celebrating ICCST at its 15th Edition
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