Themed collection Most popular 2023 analytical chemistry articles

Ultrasound-responsive polymeric materials with finely tunable physicochemical properties and acoustic responses enable their applications in imaging and therapy, such as functional/molecular imaging, targeted drug delivery, and sonopermeation.

Many unique properties in two-dimensional (2D) materials and their heterostructures rely on charge excitation, scattering, transfer and relaxation dynamics across different points in the momentum space.

Molecular imaging, including quantification and molecular interaction studies, plays a crucial role in visualizing and analysing molecular events. Aptamers are wildly employed in molecular imaging with a wide range of targets and imaging modalities.

The principles and advantages of SERS sensing strategies including multi-modal analysis for detection or mapping of key cellular biomarkers are described in this review.

More than two decades of research have established fundamental principles for the rational design of increasingly efficient polarization sources for DNP MAS NMR.

This review presents the recent advances in SARS-CoV-2 detection, including molecular diagnostics, antigen and antibody testing, and advances assay of neutralizing antibodies and emerging variants.

This work unravels that reduced ΔE and higher −ve ΔG of the electron transfer reaction are crucial for an ultrafast intrinsic photoinduced electron transfer (PET) process that enables selenourea (SeU) as an efficient fluorescence quenching probe.

We demonstrate an atom-efficient and easy to use H₂-driven biocatalytic platform for the enantioselective synthesis of isotopically labelled amino acids for protein NMR studies.

First reported in the 1800s, rhodamines have become indispensable fluorophores for biological imaging. We report a new, high-yielding synthesis of water soluble-rhodamines with a phosphonic acid instead of the traditional carboxylate.

Novel S-adenosyl-L-methionine analogues were generated enzymatically and used for regioselective benzylation of biomolecules. Applied to the mRNA 5′ cap, protein production in cells can be increased and immunogenicity altered.

We show that the polarising agent SNAPol-1 enters human cells yielding 800 MHz DNP solid-state NMR data of remarkable sensitivity & resolution thereby revealing structural heterogeneity of ubiquitin at atomic scale and with sub-cellular specificity.

A dual-path metabolic destruction-assisted therapeutic strategy by sequentially inducing apoptosis and prompting calcification of tumor cells.

While it is known that lipids play an essential role in regulating membrane protein structure and function, it remains challenging to identify specific protein–lipid interactions.

We introduce “turn-on” non-toxic fluorescent sensors as a diagnostic tool to rapidly detect and quantify total aliphatic aldehyde levels in live cells.

Current techniques could not accurately identify SUMO1, here we report a cyclic peptide with strong affinity toward SUMO1, the immobilization of CP on the nanochannel constructs a highly sensitive and specific device for detecting SUMO1 peptides.

Modulated excitation experiments coupled to time-resolved NAP-XPS allow following the dynamics of reactive species on a powder Pd/Al₂O₃ catalyst with unprecedented precision..

The preparation of a novel hypoxia-active Ru(II)-coumarin photosensitizer with advantageous luminescent and biocompatible properties for near-infrared anticancer photodynamic therapy is described.

Chemiluminescence phenoxy-1,2-dioxetane luminophores for multiplex analysis of enzymes and bioanalytes.

Black phosphorus (BP) can generate intrinsic phosphorus cluster fingerprint peaks in LDI-MS in both positive- and negative-ion modes, which allows the degradation pathways of BP to be unraveled at the molecular level without any chemical labeling.

A simple and easy-to-implement process based on a nucleophilic aromatic substitution reaction with a wide variety of nucleophiles on a fluorinated CinNapht offers unprecedented perspectives.

Schematic of fluoro-electrochemical microscopy. (a) Cartoon E. huxleyi is green under normal light, but (b) emits red fluorescence under UV. (c) Placed near an oxidizing electrode, its fluorescence fades and ultimately (d) “switches off”.

We report the use of a new dual-app nucleoside probe composed of environment-sensitive fluorescent and ¹⁹F NMR labels in dissecting the structural polymorphism of G-quadruplexes formed by the EGFR gene, which is implicated in many cancers.

We report the first molecular probe for the selective detection of the most abundant cellular inositol pyrophosphate 5-PP-InsP₅, supported by computational chemistry, as well as an efficient new synthesis.

Insertion of an indanone handle into DNA oligonucleotides permits base-catalyzed aldol to create fluorescent molecular rotor (FMR) chalcones with turn-on fluorescence and brightness suitable for biosensing applications.

This work presents an integrative framework for optimizing organic fluorophores' TICT tendency and environmental sensitivities towards various applications. Two newly developed probes could detect the early phase of Aβ aggregation.

On-demand tunable oxidation is performed during the nanoESI-MS analysis by varying the nanoflow rate and the initial droplet size. The oxidation is initiated when the electric field of the droplet reaches ∼1.3 V nm⁻¹.

We report a configuration-dependent strategy to construct bent-to-planar NIR-II fluorophores, based on an innovative rehybridization fluorogenic building block, showing promise for illuminating biological events with high spatio-temporal resolutions.

The All-in-One digital microfluidic pipeline allows for end-to-end automation of processing and analysis of mass-limited proteomic samples.

We designed two functionalized tetrahedral DNA nanostructures (f-TDN1 and f-TDN2), which could assemble into giant DNA networks triggered by APE1, achieving sensitive detection and intracellular imaging of APE1 as well as gene therapy.

A compact and clamped CHA-control-HCR (CCH) circuitry system, specifically for amplified multi-microRNA imaging, is developed to precisely distinguish cancer cells from normal cells.