Issue 55, 2016
From the journal:

Chemical Communications

Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture†

Wei Li,a   Andrew T. Bockus,a   Brittany Vinciguerra,b   Lyle Isaacs*b  and  Adam R. Urbach*a  

* Corresponding authors

a Department of Chemistry, Trinity University, San Antonio, TX, USA
E-mail: aurbach@trinity.edu

b Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA

Abstract

The recognition of human growth hormone (hGH) by the synthetic host molecule cucurbit[7]uril (Q7) was predicted on the basis of its N-terminal phenylalanine. An aqueous-compatible resin with covalently immobilized Q7 groups was prepared and shown to recognize native insulin and hGH in simple and complex mixtures.

Graphical abstract: Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

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Article information

DOI
https://doi.org/10.1039/C6CC03193E
Article type
Communication
Submitted
16 apr 2016
Accepted
10 jun 2016
First published
10 jun 2016

Chem. Commun., 2016,52, 8537-8540

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Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

W. Li, A. T. Bockus, B. Vinciguerra, L. Isaacs and A. R. Urbach, Chem. Commun., 2016, 52, 8537 DOI: 10.1039/C6CC03193E

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