Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2
Structures of intact polyketide synthase modules reveal conformational rearrangements and suggest asynchronous use of reaction chambers.
Review Article
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming
This article provides a comprehensive overview of the structural enzymology of type I iPKSs, focusing on the individual domain structures, catalytic mechanisms and the representative programming activities that each domain contributes.
Cyanophycin and its biosynthesis: not hot but very cool
Cyanophycin is a widespread natural biopolymer with promising green chemistry applications that is made by an elegant, multifunctional biosynthetic machine.
Review Article
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Nonribosomal peptide synthetases use a modular architecture to catalyze production of peptide natural products. Structural studies provide insights into the multidomain organization as well as the structural basis of catalytic domain activity.
Review Article
S-Adenosylmethionine: more than just a methyl donor
This review summarizes the chemistry of S-adenosylmethionine dependent enzymes that goes beyond methylation.
About this collection
This themed issue is guest edited by Adrian Keatinge-Clay and Janet Smith and aims to highlight the advances and importance in understanding how biosynthetic enzymes work.