Synthesis of antimicrobial active 9,10-phenanthrenequinones by carbene organocatalytic tandem reactions
An N-heterocyclic carbene organocatalytic approach that enables the rapid construction of a diverse range of PQs has been disclosed.
Access to (bridged) bicyclic ureas through azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones
Reported here is the azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones. A wide range of fused and bridged bicyclic ureas were prepared in good yield with excellent enantioselectivity.
Research Article
Access to fluorinated dienes through hydrofluorination of 2-En-4-ynoates
The hydrofluorination of enynoates has been developed for the synthesis of fluorinated dienoates.
Diverse enantioselective synthesis of hetero[7]helicenes via an organocatalyzed double annulation strategy
A versatile method has been devised for the catalytic enantioselective synthesis of hetero[7]helicenes utilizing organocatalyzed double annulation and aromatization.
Stereocontrolled desymmetrization of 2,5-cyclohexadienones via organocatalytic domino sulfa-1,6-/1,4-addition or sulfa-1,6-/1,4-/sulfa-1,4-addition reactions
A squaramide-catalyzed regio-/enantioselective sulfa-1,6-addition initiated highly enantio- and diastereoselective desymmetrization of 2,5-cyclohexadienone-tethered 3-cyano-4-styrylcoumarins has been disclosed.
Cobalt-catalyzed stereoselective synthesis of chiral gem-difluorocyclopropanes with vicinal stereocenters
We present a cobalt-catalyzed regio-, diastereo-, and enantioselective hydroalkylation of gem-difluorocyclopropenes, accessing chiral gem-difluorocyclopropanes with vicinal stereocenters.
Cobalt-catalyzed enantioselective reductive addition of ketimine with cyclopropyl chloride to construct chiral amino esters bearing cyclopropyl fragments
Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing cyclopropyl fragments with broad functional group tolerance and excellent enantioselectivities.
Research Article
Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
Entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation
Density functional theory calculation studies reveal entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation.
Research Article
A convergent paired electrochemical strategy for decarboxylative C(sp2)–C(sp3) bond formation
In this report, we describe a convergent paired electrochemical decarboxylative C(sp2)–C(sp3) cross-coupling reaction that employs readily available alkyl carboxylic acids and C(sp2)–iodides as direct coupling partners.
Nickel/photoredox dual-catalyzed reductive cross-coupling of aryl halides and aldehydes
A photoredox-assisted nickel-catalyzed reductive coupling of aryl halides and aldehydes to afford silyl-protected alcohols is reported. Key to success of this strategy is to identify α-silylamines as efficient organic reductants.
Facile and practical access to chiral benzofused oxa-heterocycles via an asymmetric hydrogenation and intramolecular SNAr cascade
Herein, we report a tandem asymmetric hydrogenation and SNAr reaction, providing valuable six- and five-membered chiral benzofused cyclic ethers with high yields and enantioselectivities (up to 99% yield and up to 99% ee).
Research Article
Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination
Pulsed electrolysis waveforms benefit primary benzylic cation generation and fluorination.
Enantio- and diastereoselective conjugate addition of pyridyl alkyl ketones to enones by Cu(II)-Lewis acid/Brønsted base catalysis
Cu(II) Lewis acid/Brønsted base catalysis was employed to achieve enantio- and diastereoselective conjugate additions of pyridyl alkyl ketones to enones, resulting in the formation of various 1,5-diketones with vicinal stereocenters.
Research Article
Asymmetric copper-catalyzed alkynylallylic dimethylamination
A reliable protocol for asymmetric Cu-catalyzed alkynylallylic dimethylamination is described with the discovery of tetramethyldiaminomethane as a new, stable and convenient surrogate of the dimethylamine nucleophile.
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