Themed collection Synthetic methodology in OBC

Organocatalytic methods and light-mediated methods have proved to be effective in chemical synthetic science. This paper compares them with the more established metal-catalyzed methods for the synthesis of a pharmaceutical core: coumarin.

This account systematizes a hundred papers (2006–2021 yy) in order to highlight the advantages of hyperbaric conditions (1–20 kbar) in preparative organic synthesis.

This review details the current scope of catalytic systems for the diastereo- and enantioselective hydrogenation of various N-heterocycles, while highlighting their applications to drug discovery.

In this review article, the currently available synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones have been discussed. This moiety is considered as a basic heterocyclic structure of the antiviral drug Riamilovir (“Triazavirin®”).

The strategic exploration of four-member “overbred intermediates” (cyclobutane based) in the total synthesis of a complex carbocyclic target structure from 1968 to 2020 is outlined in this short review.

Catalytic asymmetric Povarov reactions are reviewed, with emphasis on the use of chiral Lewis and Brønsted acids, H-bond forming catalysts and aminocatalysis. Enantioselective nitroso Povarov and interrupted Povarov reactions are also discussed.

N-Heterocycles can be found in natural products and drug molecules and are indispensable components in the area of organic synthesis, medicinal chemistry and materials science.

Synthetic utilities of 4-hydroxydithiocoumarin were explored for the construction of numerous new heterocycles involving its three different reactive sites.

The present review summarizes the advances in the synthesis of 3,3-disubstituted 3-fluorooxindole derivatives through the straightforward functionalization of 3-fluorooxindoles.

This review offers an ample opportunity to take a journey through recent advancements in C–P bond formation reactions, along with their mechanistic pathways.

This review summarises recent developments in palladium-catalyzed directed and nondirected C–H functionalization approaches to access C-branched aryl/alkenyl/alkyl glycosides with reaction characteristics and proposed mechanisms.

The synthesis of nitrogen-containing heterocycles from β-aminovinyl esters(ketones) was reviewed according to the classification of the final heterocycle synthesis.

This review illustrates recent advances and further potential of catalytic asymmetric synthesis of α-stereogenic free carboxylic acids from racemic or prochiral precursors.

Substituted adamantanes are important and versatile products that can be derived from direct C–H to C–C transformations via radical intermediates. In this review, a wide range of direct functionalization methods are summarized with a focus on mechanism and scope.

This review summarises ways to construct substituted pyrrolidines employing kinetic resolution strategies involving methods as diverse as transition metal catalysis and biocatalysis.

Functionalized 2H-chromenes are one type of important oxygen heterocycle, and have widespread applications in many areas. This review mainly focuses on the two recently established synthetic strategies towards such compounds.

A summary of literature on transition metal catalysed construction of 2-pyridone scaffolds using a wide range of coupling partners via C–H bond functionalizations has been described.

The free-radical-induced syntheses of indolizines were reviewed by type of catalyst.

Numerous metal-catalyzed reactions involving internal alkynes and aimed towards synthetically and pharmacologically important alkenes and heterocycles have appeared in the literature.

β-Keto acids: ideal ketone surrogates for diverse asymmetric nucleophilic addition reactions via a decarboxylative process.

Carbon–carbon bond activation is one of the most challenging and important research areas in organic chemistry.

In this perspective, ring-closing metathesis (RCM) based approaches for the synthesis of carbazole derivatives and other indole-fused heteroaromatic systems have been described.

N-Triflylphosphoramides (NTPA), have become increasingly popular catalysts in the development of enantioselective transformations as they are stronger Brønsted acids than the corresponding phosphoric acids (PA).

This review examines the potential of C₁-symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation of alkenes to produce pharmaceutical intermediates, bioactive molecules, drug molecules, agrochemicals, and fragrances.

We highlight significant progress in the synthesis of benzimidazo[2,1-a]isoquinolin-6(5H)-ones using C-, S-, P-, and Si-centered radicals, including the selection of the catalytic system, substrate scope, mechanistic understanding, and applications.

In recent years, decarbonylative annulation reactions have emerged as one of the most efficient routes to construct a variety of important carbocyclic and heterocyclic scaffolds.

Development of straightforward protocols for the functionalization of unactivated cyclopropanes is still challenging, the realization of which could bestow the scientific community with a recurring building block for modern organic transformations.

This review describes the oxidative cross-couplings of thiols forming various organosulfur compounds, focusing on critical intermediates such as sulfenyl halides, thiyl radicals, sulfenium cations, disulfides, and organo-transition metal intermediates.

The cyanation reaction is a key transformation due to the wide-ranging applications of nitrile compounds in organic chemistry.

Recent advances in the synthesis of O-, N-, and S-atom containing saturated 4-membered heterocycles are presented based on their preparative similarities. These strategic approaches highlight both progress made and remaining synthetic opportunities.

Recent achievements in rhodium-catalyzed arylations through C(sp²)–H bond activation were summarized.

The current landscape of nitro group directed C–H activation reactions of (hetero)arenes is reviewed.

The present review is focused on recent advances (2015–present) in the synthesis of 2,4,6-triarylpyridines (also known as Kröhnke pyridines).

Indole and its congeners are ubiquitous nitrogen containing organic scaffolds found in a plethora of natural products. This review aims to highlight the transition-metal catalyzed C–H functionalization of N-alkoxycarbamoyl indoles.

The chroman-4-one framework is a significant structural entity that belongs to the class of oxygen-containing heterocycles.

This short review highlights compelling case studies from the last five years showcasing how modern flow technology has impacted and advanced synthetic chemistry in academia and industry.

This review focuses on important cycloaddition reactions of 3-methyleneindolinones to afford 3,3′-spirocyclic oxindoles.

This review summarises the recent advances in the field of transition metal-catalyzed C–O bond activation of readily accessible unsaturated carboxylates with organometallics until May 2021.

This review focuses on recent developments in the synthesis of pyrrolo[1,2-a]indole derivatives. The mechanism, factors affecting the yield and selectivity of the product, and application to the synthesis of bioactive molecules are explained.

This review summarizes the recent developments in the synthesis and catalytic applications of 2-thiazoline ligands with literature coverage mainly extending from 2009 to 2021.

We outline the recent progress in the development of methods that enable the radical α-C(sp³)–H functionalization of ketones, with an emphasis on radical initiation systems and possible mechanisms.

In this review, we highlight the developments in chiral Cp^xM(III) complexes or achiral Cp^xM(III) complexes/chiral carboxylic acid-catalyzed enantioselective C–H functionalization reactions through migratory insertion of metal–carbenes/nitrenes.

This review summarizes the most recent organometallic, photochemical and electrochemical methods for the synthesis of perfluoroalkylated aromatic scaffolds, a family of compounds that is omnipresent in modern commercial and research applications.

Alternative solvents, ultrasound, electrochemistry and solvent-free methodologies to obtain sulfur-based compounds are herein reviewed. Special attention is paid to unconventional and/or sustainable processes.

The use of silicon-based reagents and precursors for carbon-11 labelling has shown wide applicability and robustness with short reaction times using mild conditions. In this review, recent advances and future perspectives are examined.

This review covers all the reported use of stoichiometric silicon reagents for direct amidation of carboxylic acids with amines, commencing with the first example in 1969 up until April 2021.

Palladium-catalysed isocyanide insertion reactions have witnessed great progress in recent years.

A detailed discussion on the catalytic addition of P–H bonds from various phosphine reagents to unsaturated bonds for the C–P bond formation promoted by various s- and p-block metal catalysts is reported.

This review focuses on the transition metal-free oxidative dehydrogenative aromatization reactions of cyclohexanones, with an emphasis on the scope and limitations, as well as the mechanisms of these reactions.

ortho-Alkynylarylcarbonyl derivatives, due to their unique chemical reactivity, have been employed in widely divergent synthesis for the creation of cyclic and heterocyclic small-molecule libraries.

This review summarizes the recent developments in the asymmetric intramolecular Heck reaction and carbometallation-initiated cascade transformations including Ni-catalyzed processes with literature coverage mainly extending from 2016 to 2021.

In this review, we describe the important advances in cycloaddition methodologies involving cyclopropanes for the construction of seven-, eight- and nine-membered carbocycles, with a particular attention to the variety of the mechanisms involved.

Recent progress on sustainable electrochemical synthesis involving carboxylic acids was reviewed.

This review highlights the recent developments in ipso-decarboxylative C–X (X = O/N/halo/S/Se/P/CN) bond formation using (hetero)aryl carboxylic acids, which are economical and environmentally benign starting materials.

Thioxanthone is a powerful photocatalyst. In this review, its photophysical properties and its applications in photopolymerisation and in organic synthesis are highlighted.

Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.

The overview describes synthetic routes towards substituted Meldrum's acids and its recent applications to inspire lab veterans and chemistry younglings.

This mini review summarizes the recent advances in the regiospecific nitrations of arenes and alkenes based on the structural features of substrates.

A review on the recent advances of six classes of organic photocatalysts with respect to photophysical and redox properties.

This review highlights recent advancement in the synthesis of 3-hydroxyisoindolinones and their applications in stereoselective transformations.

α-Activated cyclic isothiocyanates featuring pharmacophores were efficient percusors for the enantioselective construction of intriguing spirocycles.

This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.

This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.

This review article describes all the significant recent developments in catalytic asymmetric umpolung reactions of imines involving a 2-azaallyl anion intermediate.

This review summarizes the recent advancements in transition-metal (TM) catalyzed enantioselective C–H activation via kinetic resolution approach.

This review summarizes the-state-of-the-art advances of dearomatization strategies in the application of bridged ring formation.

This article covers ring expansions of vinylaziridines and vinyloxiranes developed over the past five years for accessing stereochemically enriched heterocycles.

The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.

This review deals with the different accesses leading to the pyrido[1,2-a]indole nucleus in the last 20 years.

Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.