Issue 6, 2011
From the journal:

CrystEngComm

Highly soluble olanzapinium maleate crystalline salts†

Ranjit Thakuriaa  and  Ashwini Nangia*a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Central University PO, Hyderabad, India
E-mail: ashwini.nangia@gmail.com

Abstract

Olanzapinium monomaleate and dimaleate salts (OLNH+ MA− 1 : 1 and OLN2H+ 2MA− 1 : 2) of crystalline and amorphous states were prepared. The crystalline salts exhibit significantly higher solubility (225–550 times) compared to the almost insoluble free base drug Olanzapine (43 mg L−1). The faster dissolution rate of the 1 : 2 salt compared to 1 : 1 is explained by their crystal structure analysis.

Graphical abstract: Highly soluble olanzapinium maleate crystalline salts

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Article information

DOI
https://doi.org/10.1039/C0CE00787K
Article type
Communication
Submitted
28 Oct 2010
Accepted
13 Dec 2010
First published
07 Jan 2011

CrystEngComm, 2011,13, 1759-1764

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Highly soluble olanzapinium maleate crystalline salts

R. Thakuria and A. Nangia, CrystEngComm, 2011, 13, 1759 DOI: 10.1039/C0CE00787K

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