Synthesis of a glycopolymeric PtII carrier and its induction of apoptosis in resistant cancer cells

Andreas Wild; Krzysztof Babiuch; Marcel König; Andreas Winter; Martin D. Hager; Michael Gottschaldt; Aram Prokop; Ulrich S. Schubert

doi:10.1039/C2CC31275A

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Synthesis of a glycopolymeric Pt^II carrier and its induction of apoptosis in resistant cancer cells†

Andreas Wild,‡^abc Krzysztof Babiuch,‡^ab Marcel König,^d Andreas Winter,^abc Martin D. Hager,^ab Michael Gottschaldt,^ab Aram Prokop^d and Ulrich S. Schubert*^abc

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* Corresponding authors

^a Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich-Schiller-University Jena, Humboldtstr. 10, 07743 Jena, Germany
E-mail: ulrich.schubert@uni-jena.de
Fax: +49 3641 948202

^b Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Humboldtstr. 10, 07743 Jena, Germany

^c Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven, The Netherlands

^d Department of Pediatric Oncology, Children's Hospital of Cologne, 50375 Cologne, Germany

Abstract

Post-polymerization modification of a poly(pentafluorostyryl) backbone with β-D-galactose and a terpyridine platinum complex yields a well-defined material that represents the first example of a metal-conjugated glycopolymer. It reveals anti-proliferative activity, no detectable necrotic cytotoxicity, and efficiently induces apoptosis in both wild-type as well as resistant Nalm-6 leukemia cell lines.

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Article information

DOI: https://doi.org/10.1039/C2CC31275A
Article type: Communication
Submitted: 20 Feb 2012
Accepted: 03 May 2012
First published: 03 May 2012

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Chem. Commun., 2012,48, 6357-6359

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Synthesis of a glycopolymeric Pt^II carrier and its induction of apoptosis in resistant cancer cells

A. Wild, K. Babiuch, M. König, A. Winter, M. D. Hager, M. Gottschaldt, A. Prokop and U. S. Schubert, Chem. Commun., 2012, 48, 6357 DOI: 10.1039/C2CC31275A

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