Issue 92, 2012
From the journal:

Chemical Communications

Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes†

Liang-Hua Zou,a   Jens Reball,a   Jakob Mottweilera  and  Carsten Bolm*a  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
E-mail: carsten.bolm@oc.rwth-aachen.de
Fax: +49 241-8092391

Abstract

A convenient transition metal-free procedure for the direct thiolation of 1,3,4-oxadiazole C–H bonds using diaryl disulfides has been developed. Other substrates including indole, benzothiazole, N-phenylbenzimidazole, and caffeine were also thiolated in this manner, providing the corresponding products in good to excellent yields.

Graphical abstract: Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

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Article information

DOI
https://doi.org/10.1039/C2CC36711D
Article type
Communication
Submitted
14 Sep 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Chem. Commun., 2012,48, 11307-11309

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Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

L. Zou, J. Reball, J. Mottweiler and C. Bolm, Chem. Commun., 2012, 48, 11307 DOI: 10.1039/C2CC36711D

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