The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences.
A. M. Abdel-Aal, G. Papageorgiou, M. Quibell and J. Offer, Chem. Commun., 2014, 50, 8316 DOI: 10.1039/C4CC03065F
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