Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

Abstract

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp²)–H functionalization for the formation of C–O bond. This transformation is mediated by I₂/TBHP/NaN₃ under metal-free conditions and a catalytic amount of NaN₃ plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.