Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography

Marine Steffann; Marion Tisseraud; Guillaume Bluet; Sebastien Roy; Catherine Aubert; Eric Fouquet; Philippe Hermange

doi:10.1039/D2CC03258A

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Last-step ¹⁸F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography†

Marine Steffann,^ab Marion Tisseraud,^a Guillaume Bluet,^b Sebastien Roy,^b Catherine Aubert,^b Eric Fouquet^a and Philippe Hermange

*^a

Author affiliations

* Corresponding authors

^a Univ. Bordeaux, Institut des Sciences Moléculaires, UMR-CNRS 5255, 351 Cours de la Libération, Talence Cedex, France
E-mail: philippe.hermange@u-bordeaux.fr

^b Sanofi, Integrated Drug Discovery (IDD) Isotope Chemistry (IC), 13 Quai Jules Guesde, Vitry-sur-Seine, France

Abstract

Aiming for potential applications in positron emission tomography, fully automated productions of ¹⁸F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di-tert-butyl-arylsilanes to a polystyrene resin. The reactions were performed using either “batch” or “flow” procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required.

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Article information

DOI: https://doi.org/10.1039/D2CC03258A
Article type: Communication
Submitted: 09 Jun 2022
Accepted: 14 Jul 2022
First published: 27 Jul 2022
This article is Open Access

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Chem. Commun., 2022,58, 9140-9143

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Last-step ¹⁸F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography

M. Steffann, M. Tisseraud, G. Bluet, S. Roy, C. Aubert, E. Fouquet and P. Hermange, Chem. Commun., 2022, 58, 9140 DOI: 10.1039/D2CC03258A

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