Issue 30, 2010
From the journal:

Chemical Communications

Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of d-glucose and d-altrose and assessment of their erythrocytetransmembrane transport†‡

Stefano Bresciani,a   Tomas Lebl,a   Alexandra M. Z. Slawina  and  David O'Hagan*a  

* Corresponding authors

a University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: do1@st-andrews.ac.uk
Fax: +44 (0)1334 463800
Tel: +44 (0)1334 467171

Abstract

The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-19F-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.

Graphical abstract: Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of d-glucose and d-altrose and assessment of their erythrocyte transmembrane transport

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Article information

DOI
https://doi.org/10.1039/C0CC01128B
Article type
Communication
Submitted
26 Apr 2010
Accepted
24 May 2010
First published
07 Jun 2010

Chem. Commun., 2010,46, 5434-5436

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Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

S. Bresciani, T. Lebl, A. M. Z. Slawin and D. O'Hagan, Chem. Commun., 2010, 46, 5434 DOI: 10.1039/C0CC01128B

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