Issue 28, 2011
From the journal:

Chemical Communications

The effect of neat ionic liquid on the folding of short peptides†

Jia Lin Huang,‡a   Michael E. Noss,‡a   Karson M. Schmidt,a   Leigh Murraya  and  Michelle R. Bunagan*a  

* Corresponding authors

a Department of Chemistry, The College of New Jersey, 2000 Pennington Rd., Ewing, USA
E-mail: bunagan@tcnj.edu
Fax: 1-609-637-5157
Tel: 1-609-771-2183

Abstract

Using circular dichroism spectroscopy, we show evidence of unusual folding behaviour for several designed peptides in neat ionic liquid. Helical peptides, AKA2 and Trp-cage, exhibit heat-induced folding, with stable helical structure persisting to 96 °C, whereas the β-hairpin Trpzip4 is destabilized by the neat [C4mpy][Tf2N].

Graphical abstract: The effect of neat ionic liquid on the folding of short peptides

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Article information

DOI
https://doi.org/10.1039/C1CC11527H
Article type
Communication
Submitted
16 Mar 2011
Accepted
02 Jun 2011
First published
13 Jun 2011

Chem. Commun., 2011,47, 8007-8009

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The effect of neat ionic liquid on the folding of short peptides

J. Lin Huang, M. E. Noss, K. M. Schmidt, L. Murray and M. R. Bunagan, Chem. Commun., 2011, 47, 8007 DOI: 10.1039/C1CC11527H

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