A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide

Konstantina Alexaki; Maria Eleni Kyriazi; Joshua Greening; Lapatrada Taemaitree; Afaf H. El-Sagheer; Tom Brown; Xunli Zhang; Otto L. Muskens; Antonios G. Kanaras

doi:10.1039/D2RA03599E

A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide†

Konstantina Alexaki,

^a Maria Eleni Kyriazi,

^b Joshua Greening,^a Lapatrada Taemaitree,^c Afaf H. El-Sagheer,

^cd Tom Brown,

^c Xunli Zhang,

^ef Otto L. Muskens^af and Antonios G. Kanaras

*^af

Author affiliations

* Corresponding authors

^a School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK
E-mail: a.kanaras@soton.ac.uk

^b College of Engineering and Technology, American University of the Middle East, Kuwait

^c Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK

^d Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt

^e School of Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK

^f Institute for Life Sciences, University of Southampton, Southampton, UK

Abstract

Since the beginning of the COVID-19 pandemic, there has been an increased need for the development of novel diagnostic solutions that can accurately and rapidly detect SARS-CoV-2 infection. In this work, we demonstrate the targeting of viral oligonucleotide markers within minutes without the requirement of a polymerase chain reaction (PCR) amplification step via the use of oligonucleotide-coated upconversion nanoparticles (UCNPs) and graphene oxide (GO).

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DOI: https://doi.org/10.1039/D2RA03599E
Article type: Paper
Submitted: 10 Jun 2022
Accepted: 13 Jun 2022
First published: 22 Jun 2022
This article is Open Access

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RSC Adv., 2022,12, 18445-18449

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A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide

K. Alexaki, M. E. Kyriazi, J. Greening, L. Taemaitree, A. H. El-Sagheer, T. Brown, X. Zhang, O. L. Muskens and A. G. Kanaras, RSC Adv., 2022, 12, 18445 DOI: 10.1039/D2RA03599E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide†

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A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide

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