Issue 4, 2024
From the journal:

Materials Advances

Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus†

Zhongchao Zhao, ORCID logo ‡abc   Young Hun Chung ORCID logo ‡cd  and  Nicole F. Steinmetz ORCID logo *abcdefgh  

* Corresponding authors

a Department of NanoEngineering, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA
E-mail: nsteinmetz@ucsd.edu

b Center for Nano-ImmunoEngineering, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA

c Moores Cancer Center, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA

d Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, USA

e Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, USA

f Institute for Materials Discovery and Design, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA

g Center for Engineering in Cancer, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA

h Shu and K.C. Chien and Peter Farrell Collaboratory, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA, USA

Abstract

We have developed nanoparticle formulations targeting M2 macrophages for cancer immunotherapy by conjugating high-affinity binding peptides to cowpea mosaic virus as an immunostimulatory adjuvant. We confirmed the targeting of and uptake by M2 macrophages in vitro and the therapeutic efficacy of the nanoparticles against murine melanoma in vivo.

Graphical abstract: Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus

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Article information

DOI
https://doi.org/10.1039/D3MA00820G
Article type
Communication
Submitted
07 Oct 2023
Accepted
17 Jan 2024
First published
26 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 1473-1479

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Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus

Z. Zhao, Y. H. Chung and N. F. Steinmetz, Mater. Adv., 2024, 5, 1473 DOI: 10.1039/D3MA00820G

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