Themed collection 2025 Pioneering Investigators

Extracellular vesicles have been deemed as potential drug carriers for treatment of various diseases. Recent advances have been summarized, including the sources, delivery function, extraction and cargo-loading technology of extracellular vesicles.

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening the understanding of the applications.

Amidation reactions play a crucial role in the effective functionalization of nanopores and nanochannels.

We review the interplay between valence tautomerism, structural tessellations, and magnetic phenomena in lanthanide-based coordination networks, culminating in the discovery of a thermally activated valence tautomerism in a lanthanide-organic net.

HPV screening is critical for the diagnosis of cervical cancer. This study combines photoactivated CRISPR-Cas12a with a tube-in-tube structure and RPA for rapid HPV16 detection, using blue UV light at 302 nm for portable, on-site diagnostics.

We propose a novel computational method to predict the crystal structures of bowl-shaped π-conjugated molecules and to reproduce their assembly structure from randomly dispersed molecules using all-atom molecular dynamics (MD) simulation.

The thermal and chemical stability of mesoporous Zr and Hf MOFs (MIP-206, MOF-808, NU-1000) and microporous UiO-66 were investigated, with a focus on the effects of metal type, linker type, and topology on the framework stability.