Themed collection Food & Function Recent HOT articles

Phenolic compounds (PC) are secondary metabolites with interesting bioactivities that have been explored for industrial application. PC bioactivity depends on their chemical structure integrity, so, methods to increase PC stability have been developed.

This narrative review investigates whether low/moderate consumption of wine/grape's derivatives can be part of T2D individuals daily diet.

Plot of the maximum plasma melatonin levels (C_max) following the oral administration to humans of pure melatonin in various rapid release formulations.

Synergistic potential of nutraceuticals in chronic disease management.

Black soybean (Glycine max L.), a cultivar containing abundant polyphenols in its seed coat such as anthocyanins and flavan-3-ols, has been reported to possess various health benefits toward lifestyle diseases.

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of almond intake on anthropometric indices in adult subjects.

Higher intakes of flavonoid-rich foods are associated with a lower risk of cardiovascular disease in prospective cohort studies.

Galactolipases allow the digestion of galactolipids, the most abundant lipids on Earth and the main source of α-linolenic acid.

Diet could play a dual role in the production of the TMA/TMAO meta-organismal pathway since it provides TMA precursors, but also other dietary constituents that reduce endogenous TMAO or its damaging effects through different mechanisms.

Relationship between “stressors” and “stress responses”, such as hormone secretion. Some polyphenols can prevent stress responses, which subsequently prevent stress-related health problems.

Coffee chlorogenic acids do not affect carbohydrate digestion directly, but modulate glucose absorption/utilisation, the latter through endogenous/gut microbiota metabolites.

In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).

Phytophenols are important bioactive food based chemical entities, largely present in several natural sources.

The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular carcinoma (HCC) by promoting the clearance or elimination of sorafenib via the drug resistance-related downstream genes of the PXR. Rhamnetin drepresses the activation of PXR via miR-148a.

The aim of this study was to exploit the inherent properties of eugenol to restrict the growth of cancer cells in a tobacco-related human carcinogen NDEA-induced lung carcinogenesis model in vivo as a chemopreventive agent.

Fructose-induced hepatic miR-33 suppression lead to fatty liver via upregulation of SREBP1. Additionally, fructose-induced hepatic ferroptosis may cause a spill-over of miR-33 into blood stream, which could be a potential serological biomarker for fructose-induced NAFLD.

Wheat germ glycoprotein (WGP) is widely used due to its nutritional benefits and biological activity.

Compounds isolated from Semen Celosiae are potent inhibitors of neuron injury via inhibition of oxidative stress and apoptosis, and activation of autophagy.

Synergistic biological activities of probiotics and curcumin can be achieved based on the gut–brain axis.

Olea europaea-derived samples as natural source for abdominal pain relief in gastrointestinal disorders.

The study demonstrates that prenatal vitamin D supplementation reduces blood pressure and restores angiogenic balance in an animal model of preeclampsia.

The effect of lactic acid fermentation on the gastroduodenal digestibility and immunoglobulin E-binding capacity of soy proteins was assessed using an in vitro dynamic gastrointestinal digestion model.

The black bean is a legume widely consumed in Latin America, however its consumption has decreased significantly in recent decades.

Nevadensin alleviated mice allergic reactions, attenuated passive cutaneous anaphylaxis and suppressed mast cells activation. Nevadensin diminished c-Kit receptor expression, inhibited the proliferation and accelerated the apoptosis of mast cells.

Lactobacillus plantarum can relieve diarrhea caused by enterotoxigenic Escherichia coli (ETEC), but the remission mechanism has not been fully explained.

In this study, exopolysaccharides (EPSs) from fungus Aspergillus cristatus (MK346334) isolated from Fuzhuan brick tea maintained gut homeostasis and exhibited immunomodulatory activity in cyclophosphamide-treated mice.

β-Glucan, an economical by-product of yeast,  showed a similar probiotic activity to inulinw, which is expected to be a potential prebiotic for the modulation of gut microbiota.

AFE activates p53, acting on apoptosis, autophagy, senescence, and metastasis, and induces mitochondrial dysfunction.

(−)-Epicatechin reduces neuroinflammation and Tau-hp, improving memory and learning.

Minimally processed plant oil used as a novel source to prepare oleogels for cookie making.

Particle size distribution and particle size ratio have an important effect on rheological properties of model chocolate samples, but also other factors like particle shape, surface roughness and hydrophilicity should be taken into account.

The aim of this study was to evaluate the release of phenolics, biological activity variation and prebiotic potential of whole gold kiwifruit and pomace by in vitro digestion and colonic fermentation.

The dietary peroxidized lipid, 13-HPODE, stimulates natural killer cell granzyme B production and secretion, with potential implications for intestinal inflammation.

The rheological behavior, assembly measurements, thermal stability, molecular conformation, and molecular interactions of myofibrillar proteins (MP) modified by transglutaminase (TGase) and epigallocatechin-3-gallate (EGCG) were investigated.

Black garlic MLDs fermented in the colon, produced SCFAs and modulated gut microbiota composition, thereby protected against hepatic lipid accumulation, insulin resistance, and inflammation partly.

The aim of this study is to explore the hepatoprotective potential of coix seed protein hydrolysates (CPP) against alcohol-induced liver injury, and investigate the underlying mechanisms.

Mechanism of DHA combined with RES in inhibition of cancer cell migration by DLC1/TCTP/Cdc42 signaling.

The present investigation further unravels the underlying molecular mechanism of WGH on T2DM: IRS-1/PI3K/Akt pathway and related miRNA expression.

This study was conducted to explore the protective potential of fructooligosaccharides (FOS) against enterotoxigenic Escherichia coli (ETEC)-induced inflammation and intestinal injury in weaned pigs.

LRa05 resists obesity via ameliorating Streptococcus level and glucose metabolism, moreover, the positive correlation between Intestinimonas and palmitoyl ethanolamide and the negative correlation between Enterorhabdus and vitamin B2 are first found.

Pilose antler (PA) is a traditional Chinese functional food and 22 tumor-suppressing polypeptides was detected in its water extract. They inhibit the progression and metastasis of triple-negative 4T1 breast cancer at multiple key sites.

Postharvest storage negatively influences the common bean mineral bioaccessibility which cannot be counteracted by adapting conventional processing variables. However, dehulling can lead to an improvement of mineral bioaccessibility.

NAFLD (non-alcoholic fatty liver disease) is a multifactorial liver disease related to multiple causes or unhealthy conditions, including obesity and chronic inflammation.

Bone and energy metabolism are profoundly influenced by exercise.

Eugenol-loaded chitosan emulsion (ELCE) has been proved to have an excellent antibacterial property.

The contents of major bioactive compounds in health performance coffees and conventional coffees sold in the U.S. market were compared. Many health claims on the health performance coffee labels were unjustified.

This study explores the antioxidative effect of a specific wheat germ-derived peptide on high glucose-induced oxidative stress in vascular smooth muscle cells (VSMCs) and the underlying mechanisms.

Carob is the fruit obtained from Ceratonia siliqua L. and it is a source of bioactive compounds that have been linked to several health promoting effects, including lowering blood cholesterol concentration.

Commercial whey products promote healthy gut by upregulating barrier function related molecules with glycomacropeptide (GMP) having enhanced activity in protecting colon cells against inflammation.

We report that sacha inchi oil with plant-derived ω-3 PUFAs alleviates gut microbiota dysbiosis, prevents bile acid dysmetabolism, and ameliorates hepatic lipid dysmetabolism of glycerolipids, glycerophospholipids, and sphingolipids in HFD rats.

Colorectal cancer (CRC) is one of the most common types of cancer, especially in Western countries, and its incidence rate is increasing every year.

Galactooligosaccharides (GOS) are useful dietary ingredients recognized worldwide as prebiotics.

This study provides new insights and indicates that LYC prevents DEHP-induced mitophagy of spermatogenic cells via the mitochondrial quality regulation, which may be the target molecule for future DEHP toxicity and the LYC effector mechanism.

In this study, heat-assisted extraction (HAE) was used to optimise the extraction of ergosterol from Pleurotus ostreatus (PO) and Pleurotus eryngii (PE) using response surface methodology (RSM).

Mechanisms to slow down starch digestion – tea polyphenols interact with α-amylase and starch during co-digestion of tea extract and bread.

The antioxidant activity of monascin characterized by both theoretical prediction and experimental validation via colorimetric and electron spin resonance (ESR) assays.

Water binding capacity and viscosity of soluble dietary fibers are known to be essential drivers of their nutritional benefits.

LAB exhibiting hypoglycaemic effects reduced insulin resistance by contributing to the production of SCFAs and alleviation of inflammation. L. rhamnosus regulated blood lipid more efficiently than Bifidobacterium.

Citrus phytochemical auraptene activates the drug efflux transporter P-glycoprotein gene (MDR1) promoter in human intestinal LS174T cells. Auraptene increases protein expression of P-glycoprotein. Auraptene can cause food–drug interactions.

Whey proteins denaturing ≤65 °C are important for allergy protection by raw cow's milk.

Recent research indicates that the food matrix can influence digestion kinetics and uptake of nutrients, thus affecting human health.

This study investigated the effect of complexation with whey and casein protein, respectively, on post prandial absorption of vitamin D₃.

New peptides with cholesterol esterase and pancreatic lipase inhibitory activities were identified from brewer's spent grain hydrolysate, providing added value to this by-product obtained from the beer industry.

Olive processing generates large amounts of stones with high protein contents.

Flavanol intake positively influences cardiometabolic health in humans – evidence from in vitro nutrigenomic studies.

In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.

C. elegans-based activity guided and size-based isolation of antioxidant peptide fractions from a sea cucumber protein hydrolyzate and their bioinformatic characterization.

The inhibitory effect of dietary 5-demethylnobiletin on colitis-driven colorectal carcinogenesis and the potential roles of its colonic metabolites were reported.

This research examined the antioxidant abilities of peptides derived from the Hericium erinaceus mushroom produced via three microbial proteases at varying concentrations.

Aberrant activation of inflammation and excess accumulation of lipids play pivotal roles in atherosclerosis (AS) progression.