Review Article
Exploring DNA–protein interactions on the single DNA molecule level using nanofluidic tools
This review highlights the use of nanofluidic channels for studying DNA–protein interactions on the single DNA molecule level.
Review Article
New advances in probing cell–extracellular matrix interactions
This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.
Review Article
T cell immunoengineering with advanced biomaterials
Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.
Review Article
Next generation of network medicine: interdisciplinary signaling approaches
We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.
Review Article
The appeasement of Doug: a synthetic approach to enhancer biology
In this review, we discuss how we can use synthetic approaches to study animal enhancers, as well as the importance of both positive and negative results for advancing the field of developmental gene regulation.
Review Article
Nature versus design: synthetic biology or how to build a biological non-machine
We suggest that progress in synthetic biology will be achieved by abandoning the bio-machine paradigm and by using an alliance between engineering and evolution as a guiding tool.
Paper
Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts
Lmna knockout causes an impaired actin stress fiber organization which results in a fivefold lower contractile stress generation.
Paper
Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)
Multi-functional scaling is a mechanistic framework to design integrated microphysiological systems for pharmacological applications.
Paper
Template-assisted extrusion of biopolymer nanofibers under physiological conditions
Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions.
Paper
Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
We construct a pathway de novo for microenvironment-specific genetic regulators of acute lymphoblastic leukemia using RNAi screening, and mRNA data.
Paper
Three-dimensional hierarchical cultivation of human skin cells on bio-adaptive hybrid fibers
Bio-adaptive hybrid fibers simulating the complex biomechanical characteristics of the native human extracellular matrix were developed as bio-inspired functional materials for biomedical applications.
Paper
Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry
Mechanical measurements of skeletal stem cells using RT-DC reveal a distinct sub-population within the human bone marrow.
Paper
Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets
Using 1D arrangements of microdroplets to exchange chemical messages between cell-free systems and bacteria.
Paper
Fully quantified spectral imaging reveals in vivo membrane protein interactions
Fully quantified spectral imaging is a new tool for probing the stoichiometry and stability of protein complexes in biological membranes.
Paper
Mimicking the topography of the epidermal–dermal interface with elastomer substrates
Micro-scale topography mimics stem cell patterning in human interfollicular epidermal stem cells.
About this collection
Please see below for recent Open Access papers published in Integrative Biology.