Themed collection Lab on a Chip HOT Articles 2025

This review outlines a system-level framework for active implantable drug delivery systems (AIDDSs), analyzing how design choices in actuation, powering, and communication affect clinical translation and the development of scalable devices.

Vascular microphysiological systems (MPS) are biologically relevant platforms, enabling the study of physical parameters (shear stress, interstitial flow, permeability) and biomedical applications (tissue modeling, cancer research, drug screening).

Smartphones have the potential to transform chemical and biological analysis by functioning as portable, versatile, and democratized platforms for molecular diagnostics. Recent advances in optical detection and devices are reviewed.

This review examines contributions of microfluidic technology to SELEX-based aptamer identification, with alternative methods such as in vivo-like SELEX and Non-SELEX for selecting aptamers and discussed critical SELEX steps over the past decade.

Centrifugal microfluidics, with its advantages of rapid and precise fluid control without the need for external pressure, is widely applied in point-of-care testing.

Using DEP, plasmonic metal nanoparticles were uniformly assembled into a patterned substrate, forming consistent hotspots and stable SERS signals. The resulting SERS-active substrate enabled highly sensitive molecular detection down to 10⁻¹⁰ M.

We report the synthesis of a fluorophilic boronic acid copolymer surfactant which rigidifies the water/fluorinated oil interface to stabilize droplets.

Using antibody-coated particle aggregation, triggered in the presence of an antigen, enables bioselective separation in nanoscale deterministic lateral displacement, opening this technique for targeting colloids based on biochemical profiles.

The key elements in the development of the LEADS chip are highlighted; the crucial features of the chip for mimicking NASH in vitro and its applicability as a pre-clinical drug testing model.

The printing accuracy in LCD-based 3d printing was enhanced using an immobilized release film.

Integrated mechanical compression and dual-frequency impedance reveal mechanical opacity as a dynamic, label-free marker of single-cell mechanics and membrane permeability for phenotypic classification.

A smartphone-integrated microfluidic photoelectrochemical aptasensor enables automated, sub-pM kanamycin detection via enzymatic–magnetic cascaded amplification and wireless readout.

Tapered microchannels modify the gas–liquid flow to the annular regime, enabling void-free filling of blind microchambers without the need for complex treatments or external forces.

This work proposes an acoustic streaming (AS) regulation system, achieving effective results in regulation of various behaviors of neuroectodermal stem cells through precise and adjustable AS shear forces.

This study presents a micro-3D printed concentrator with micro-pores for solvent evaporation, designed for low-temperature, small-volume sample processing.

A membrane-based immunosensor with high sensitivity and antifouling property is designed by numerical modeling and demonstrated in interleukin-6 detection.

Our 3D DNS-PT modeling approach can predict the inertial focusing of sperm cells with long tails, bridging the gap in understanding the inertial migration of flagellated cells and facilitating the better design of microfluidic sorting devices.

This work introduces a compartmentalization-free digital detection technique that enhances sensitivity for detecting low-abundance proteins in an automated microfluidic format.

Mimicking Earth's rotation and revolution, a dual-mode rolling strategy is developed for dual-cycle synergy in capture-based detection of trace targets.

Organoid-slice-on-a-chip that integrated patient-derived cholangiocarcinoma organoids (CCOs) with recellularized tissue slices provides a biomimetic system for assessing anticancer drug efficacy and hepatorenal toxicity.

A multi-channel wearable sensing patch based on gate-all-around field-effect transistors that enables comprehensive health monitoring.

MSC infiltration of diabetic vasculature.

PFH-embedded knotted microfibers engineered via microfluidic spinning achieve triggered fire suppression in confined electrical systems.

This study develops a self-perfusion microfluidic chip driven by evaporation that maintains cell culture without external pumps, enabling stable, long-term drug screening and toxicity testing for personalized medicine.

This study presents a novel method for synthesizing phospholipid vesicles using an electrokinetic turbulent microreactor. Multilamellar and giant unilamellar vesicles can be simply produced with their size and morphology being controllable.

Our microcavity array solution achieves unbiased cell isolation, rapid reagent exchange, and efficient staining for identifying tumor cells in blood.

A 3D microfluidic platform for single-cell chemotaxis studies and active cell sorting based on chemotactic phenotypes across diverse applications.