Themed collection The Synergy of Synthetic Methods Development and Natural Product Synthesis

In this review, we examine the origins and synthesis of bioactive spiroketal-containing natural products isolated from traditional Chinese medicines.

This review described the total synthesis of naturally occurring cyclic peptides covering 2020 to 2022 paying particular attention to the construction of their unique structures via macrocyclization.

This review highlights a curated selection of publications utilizing homogeneous gold-catalyzed cycloaddition and cyclization reactions for the total synthesis of natural products reported from 2016 to mid-2023.

This review highlights controllable skeletal reorganization, which involves the formation, cleavage, and migration of C–C and C–heteroatom bonds, as a powerful strategy in the efficient syntheses of steroid, terpenoid and alkaloid natural products.

This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.

This review highlights modern uses of oxidative phenol coupling in the total synthesis of natural products, spanning catalytic, electrochemical, stoichiometric and enzymatic approaches.