Gold-catalyzed cyclization and cycloaddition in natural product synthesis
This review highlights a curated selection of publications utilizing homogeneous gold-catalyzed cycloaddition and cyclization reactions for the total synthesis of natural products reported from 2016 to mid-2023.
Review Article
Controllable skeletal reorganizations in natural product synthesis
This review highlights controllable skeletal reorganization, which involves the formation, cleavage, and migration of C–C and C–heteroatom bonds, as a powerful strategy in the efficient syntheses of steroid, terpenoid and alkaloid natural products.
Recent asymmetric synthesis of natural products bearing an α-tertiary amine moiety via temporary chirality induction strategies
This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.
Recent advances in oxidative phenol coupling for the total synthesis of natural products
This review highlights modern uses of oxidative phenol coupling in the total synthesis of natural products, spanning catalytic, electrochemical, stoichiometric and enzymatic approaches.
About this collection
This collection, guest edited by Chris Vanderwal and Noritaka Chida, aims to showcase how natural products have inspired the development of new chemical methods, and how the advent of new methods has been facilitating more efficient chemical syntheses of natural products.