Cobalt-catalyzed stereoselective synthesis of chiral gem-difluorocyclopropanes with vicinal stereocenters
We present a cobalt-catalyzed regio-, diastereo-, and enantioselective hydroalkylation of gem-difluorocyclopropenes, accessing chiral gem-difluorocyclopropanes with vicinal stereocenters.
Cobalt-catalyzed enantioselective reductive addition of ketimine with cyclopropyl chloride to construct chiral amino esters bearing cyclopropyl fragments
Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing cyclopropyl fragments with broad functional group tolerance and excellent enantioselectivities.
Research Article
Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
Entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation
Density functional theory calculation studies reveal entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation.
Research Article
A convergent paired electrochemical strategy for decarboxylative C(sp2)–C(sp3) bond formation
In this report, we describe a convergent paired electrochemical decarboxylative C(sp2)–C(sp3) cross-coupling reaction that employs readily available alkyl carboxylic acids and C(sp2)–iodides as direct coupling partners.
Nickel/photoredox dual-catalyzed reductive cross-coupling of aryl halides and aldehydes
A photoredox-assisted nickel-catalyzed reductive coupling of aryl halides and aldehydes to afford silyl-protected alcohols is reported. Key to success of this strategy is to identify α-silylamines as efficient organic reductants.
Facile and practical access to chiral benzofused oxa-heterocycles via an asymmetric hydrogenation and intramolecular SNAr cascade
Herein, we report a tandem asymmetric hydrogenation and SNAr reaction, providing valuable six- and five-membered chiral benzofused cyclic ethers with high yields and enantioselectivities (up to 99% yield and up to 99% ee).
Research Article
Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination
Pulsed electrolysis waveforms benefit primary benzylic cation generation and fluorination.
Enantio- and diastereoselective conjugate addition of pyridyl alkyl ketones to enones by Cu(II)-Lewis acid/Brønsted base catalysis
Cu(II) Lewis acid/Brønsted base catalysis was employed to achieve enantio- and diastereoselective conjugate additions of pyridyl alkyl ketones to enones, resulting in the formation of various 1,5-diketones with vicinal stereocenters.
Research Article
Asymmetric copper-catalyzed alkynylallylic dimethylamination
A reliable protocol for asymmetric Cu-catalyzed alkynylallylic dimethylamination is described with the discovery of tetramethyldiaminomethane as a new, stable and convenient surrogate of the dimethylamine nucleophile.
About this collection
Organic Chemistry Frontiers is pleased to publish this Emerging Investigator Series to highlight early-career scientists and their excellent research at the forefront of organic chemistry.
Scientists featured in the collection are recognized for the high novelty of their research, their outstanding contributions made during independent career stages, as well as the potential to influence chemistry in future.
More details about the Emerging Investigator Series can be found below, including details on how to apply for considerations. This collection will be updated when new Emerging Investigator Series papers are published – so keep checking this page and watch the collection grow!
Check out the call for papers by Organic Chemistry Frontiers, Materials Chemistry Frontiers and Inorganic Chemistry Frontiers.
Explore the Organic Chemistry Frontiers Emerging Investigator Series 2022–2023