Themed collection RSC Advances Organic Chemistry year in review 2024

This article describes recent advances in one-pot chemoselective reactions and their mechanism insights. Here, the substrate, catalyst, solvent, and temperature play a vital role in modulating chemoselectivity.

Chiral 1-substituted-THβC can be synthesized from L-tryptophan or tryptamine by Pictet–Spengler reaction and chiral auxiliary; also from substituted-DHβC by ATH reaction with chiral catalysts, asymmetric addition reaction, and enzymatic catalysis.

Cashew nut shell liquid (CNSL) is the preferable choice for industrial scenarios to meet their goals of sustainability. The unique structural properties of CNSL is the key to developing eco-friendly surfactants.

Baeyer–Villiger oxidation is a renowned reaction that provides an efficient route for the synthesis of biologically active natural products such as alkaloids, terpenoids, polyketides and fatty acid-based naturally occurring organic compounds.

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

A library of 18 optically biased spiropyran photoswitches were synthesised and evaluated using NMR and UV-vis spectroscopy. A strategy for synthesis of optically active spiropyrans and a new purification method for such compounds are also reported.

An intramolecular arylogous nitroaldol condensation has been developed for the synthesis of benzoheterols under transition metal-free conditions and synthesized an advanced key intermediate of saprisartan—thus constituting a formal synthesis.

This work explores new synthetic methods for euxanthone and its derived dye Indian yellow through euxanthic acid formation, confirming structures with analytical techniques and proposing a mechanism for the euxanthone synthesis.

This study reports the use of phenylsulfonates as photolabile groups to generate aryl radicals, which undergo radical cyclization to yield triphenylene derivatives. The reaction is efficiently carried out under 365 nm with a triplet sensitizer.

Fluorene moiety-containing thiazole Schiff-bases were synthesized, and their antimicrobial and antioxidant activities were determined through molecular docking and molecular dynamics studies.

Two new bonds (C–C and C–N) are formed in one step without metal catalysts showing the potential of this transformation.

Total synthesis of bicyclomahanimbine has been disclosed via a late-stage Cu(II)-mediated Photoredox process. The use of Cu(OTf)₂ played crucial roles in controlling reaction outcomes and maximizing yields.

Step economical routes for the multigram preparation of popular VHL E3 ligase recruiting ligands.

PBIs were synthesized from the reaction of perylene bisanhydrides and primary amines in imidazole as solvent. Maleimide, anthraquinone or ferrocene were bonded to the side chain and the S-trityl group was replaced by imidazole in S-trityl cysteine.

A user-friendly LC-MS data-independent acquisition-based strategy using open software for access to the flavonoid content of complex mixtures.

A scalable and selective N1-alkylation of indazoles broad in scope and suitable for manufacturing scale.