Themed collection Bioactive surfaces for hard tissue regeneration

Welcome to this themed issue of RSC Advances on bioactive surfaces for hard tissue regeneration.

A review of the literature concerning the surface modification of titanium by plasma electrochemical oxidation is presented.

The pathway followed by bioactive ceramics from their early use as bone grafts until the present day, where they are widely investigated to obtain porous scaffolds for bone tissue engineering, is reviewed.

This review documents the plethora of biomaterials for bone tissue engineering applications in tandem with experimental and brief theoretical studies on cell responses on textured substrates.

Multicomponent bioactive nanostructured films (MuBiNaFs) with an excellent combination of various properties were developed and deposited by sputtering of composite targets produced via the self-propagating high-temperature synthesis method.

This review summarizes the methods for immobilization of growth factors on inorganic materials for hard tissue engineering.

Utilizing carbon nanostructures as high-performance scaffold materials in hard tissue engineering is both promising and challenging.

Non-cytotoxic bioactive composite fibers were synthesized on electrospun nanofibers containing amine and carboxyl groups on the surface.

Nanoporous silica nanoparticles with immobilized BMP2 as depicted in the scheme effectively promote osteogenic differentiation of mesenchymal stem cells.

A bioactive surface layer that released Mg²⁺ ions was produced on the surface of titanium metal (Ti) by chemical and heat treatments.

Calcium-phosphate by new autocatalytic bath on 316L and PP-PE improves cells density in PP-PE (A) and 316L (C) compared to the untreated PP-PE (B) and 316 L (D).

A structural and chemical analysis of nanofibers synthesized via interfacial mineralization of calcium phosphate beneath monolayers of poly(n-butylmethacrylate)-block-poly[2-(dimethylamino)ethyl methacrylate] at the air–water interface.

Titanium nanotube porosity to control the dissolution of sputter deposited calcium phosphate thin films.

Functionalizing titanium (Ti) implants with bioactive agents appears to be attractive for accelerating osseointegration.

Novel aspects are polymer tubes for external and internal blood circulation modified with non-cytotoxic and anti-thrombogenic coatings tested through advanced interdisciplinary biophysical investigations on blood in patient-like conditions.

Silicate-containing hydroxyapatite-based coatings with different structure and calcium/phosphate ratios were prepared by rf-magnetron sputtering.

Novel bioactive nanostructured-TiO₂/chitosan coatings obtained by electrophoretic deposition with tailored contact angle and corrosion protection for orthopaedic devices.

The synthesis of nanocomposite polymer-based coatings was produced from active gas phase formed by electron beam dispersion of polymer and biocide agent in vacuum.

TiO₂ nanofilms on a titanium surface prepared by hydrothermal treatment are of hierarchical architectures and exhibit improved bioactivity and bacteriostasis.

Novel Ti-based layers prepared by plasma and ion beam technologies were demonstrated to have good cytocompatibility and are suitable for application in biomedicine.

Bead-encapsulation of bone cells is a useful technique to produce bioactive programmable hydrogels.

We obtain a bioactive coating on the Ti–13Nb–13Zr alloy via plasma electrolytic oxidation and additional alkali treatment.

Silicon-containing hydroxyapatite (SiHA) and silver-containing hydroxyapatite (AgHA) have been shown to provide enhanced bioactivity and antibacterial properties over pure hydroxyapatite (HA), respectively.

Nanofibrous and nanorod-shaped Sr₁-HA with lateral spacing of less than 100 nm, and nanogranulated Ca_0.5Sr_0.5TiO₃ were hydrothermally grown on micro-arc oxidized microporous and nanocrystallized TiO₂, respectively, to form multilayer coatings.

Titania (TiO₂) films of different phase compositions and surface topographies grown from chemically different precursors showed markedly different bioresponses, manifested in differential cell growth and proliferation behaviour.

Calcium phosphate nanoparticles with different compositions and morphologies were prepared and loaded with DNA. These nanoparticles can be used for transfection of different cell types and are highly biocompatible.

The biocompatibility of a calcium phosphate coating synthesized by pulsed electrodeposition is assessed by observing its behaviour in contact with human osteoblast-like cells (MG-63).

SaOS-2 cells growing on 3D printed grids formed of silica-impregnated Ca-sulfate retain the ability to express osteoprotegerin and BMP-2, suggesting that 3D printed matrices, processed with silica, might function also as a morphogenetic material in vivo.