Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds
Chiral sp3-geminated bimetallic reagents based on B, Si, and Sn have drawn much attention due to their unique structure and reaction mode. This review summarizes the synthesis of nonracemic gem-borylstannyl, gem-borylsilyl, and gem-diboryl compounds.
Review Article
Mechanophoric hydrogels: when mechanical stress produces useful responses
Mechanophoric hydrogels undergo visible color changes or alterations in optical properties in response to mechanical stimuli.
Recent advances in the synthesis of nitrogen heterocycles via Rh(III)-catalyzed chelation-assisted C–H activation/annulation with diazo compounds
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
Recent advances in enantioselective construction of C–N bonds involving radical intermediates
This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates.
Review Article
Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles
Skeletal editing enables atom-level modifications to molecular skeletons. This review highlights advances in single-atom insertions, deletions, and transmutations in (hetero)cyclic systems, offering a comprehensive view on cutting-edge strategies.
Photochemical generation of heteroatom (N, Si, B) or carbon radicals leveraging preinstalled carboxylic acids
This review provides an overview of recent advancements in generating N, Si, B, and C radicals through the decarboxylation of preinstalled carboxyl substrates under visible light catalysis.
UV/visible light-promoted external photocatalyst-free transformations: A Decade's Journey of N-heterocycles and their functionalisation
We have provided a comprehensive analysis of the construction of N-containing heterocyclic compounds and their functionalization without the use of external photocatalysts, under UV/visible-light exposure in different conditions.
Review Article
AI molecular catalysis: where are we now?
Artificial intelligence (AI) is transforming molecular catalysis by addressing long-standing challenges in retrosynthetic design, catalyst design, reaction development, and autonomous experimentation.
Polyfluorinated reagents for peptide stapling
Fluorinated reagents have emerged as a valuable tool in peptide chemistry. This review summarizes recent advances in polyfluorinated reagents for peptide stapling, exploring their design principles, reaction mechanisms, and biological applications.
Recent advances on electrocyclic reactions in complex natural product synthesis: an update
The recent advances on the application of electrocyclic reactions in the total synthesis of notable natural products are summarized.
Nitrogen-containing polycyclic aromatic hydrocarbons (PAHs) with bowl-shaped structures: synthesis, architecture, and applications
This highlight discusses the synthesis strategies and topological features of nitrogen-containing bowl-shaped polycyclic aromatic hydrocarbons.
Recent advances in catalytic asymmetric reactions of Morita–Baylis–Hillman adducts
Morita–Baylis–Hillman adducts have become an efficient synthon for the construction of C–C or C–heteroatom bonds, and have been widely used in the asymmetric synthesis of various new optically pure compounds.
Progress in the catalytic enantioselective construction of difluoroalkylated stereogenic centers
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
Unraveling the α-Effect in α-Fluorinated Carbanionic Nucleophiles: Origins and Synthetic Implications
A chiral ferrocene-tethered ruthenium diamine catalyst for asymmetric transfer hydrogenation of ketones
A new chiral ferrocene-tethered ruthenium diamine catalyst has been developed for the asymmetric transfer hydrogenation of different types of ketones.
Photocatalytic intermolecular [2+2] cycloaddition/dearomatization of indoles: easy access to cyclobutane-fused indolines
Charge separation and intersystem crossing in compact orthogonal and sterically encumbered 6,12-diphenyl indolo[3,2-b]carbazole-naphthalimide electron donor-acceptor dyad
t BuOK-mediated selective 1,2-silacarboxylation of arylalkenes with Si–B/Si–Si/Si–Li reagents and CO2
An efficient and practical tBuOK-mediated selective 1,2-silacarboxylation of arylalkenes with CO2 has been established. This protocol provides a convenient route to construct a wide range of β-silyl functionalized phenylacetic acid derivatives.
Asymmetric α-selective allylation of the amide unit of maleimides and alkenyloxindoles by dual-functional InIII/N,N′-dioxide complex
Asymmetric α-selective allylations of the amide unit of maleimides and alkenyloxindoles were achieved by a dual-functional InIII/N,N′-dioxide complex.
Photoredox β-C(sp3)–H heteroarylation of o-iodoaryl-alkan-1-ones with heteroarenes via HAT and dual C–H functionalizations
A formal ketone β-heteroarylation via iodoarene-directed photoredox remote C(sp3)–H heteroarylation of o-iodoaryl-alkan-1-ones with heteroarenes is depicted.
Synthesis of carbazoles: light-promoted tandem coupling of nitroarenes with Grignard reagents
An efficient method for the one-pot synthesis of carbazoles from readily available nitroarenes and Grignard reagents is reported, featuring a light-promoted intermolecular tandem amination and C–C bond coupling reaction.
Research Article
Combination of the structural components of amino acids with fatty acids: access to an unknown class of “fatty” α-amino acids by palladium-catalyzed amidocarbonylation
A new class of fatty amino acids, integrating fatty acids motifs, is synthesized in one step via palladium-catalyzed amidocarbonylation.
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Read our on-going collection of the hottest research published as advance article from Organic Chemistry Frontiers in 202 5 . These articles are recommended by reviewers as being of significant novelty and interest. Congratulations to all the authors whose articles are featured!