Issue 18, 2001
From the journal:

Chemical Communications

Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction

S. Adrian Saldanha,†a   Louise M. Birch,†a   Michael E. Webb,a   Brent K. Nabbs,a   Frank von Delft,b   Alison G. Smithc  and  Chris Abell*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ca26@cam.ac.uk

b Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK

c Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, UK

Abstract

The decarboxylation of L-aspartate by E. coliL-aspartate-α-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.

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Article information

DOI
https://doi.org/10.1039/B106090M
Article type
Communication
Submitted
10 7 2001
Accepted
30 7 2001
First published
29 8 2001

Chem. Commun., 2001, 1760-1761

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Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction

S. A. Saldanha, L. M. Birch, M. E. Webb, B. K. Nabbs, F. von Delft, A. G. Smith and C. Abell, Chem. Commun., 2001, 1760 DOI: 10.1039/B106090M

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