Themed collection MXene chemistries in biology, medicine and sensing

MXene-based aptasensors: a perspective on recent advances
Recent advancements in science and technology have significantly enhanced public health by integrating novel materials and early diagnostic methods.
Nanoscale, 2024,16, 22128-22141
https://doi.org/10.1039/D4NR03984J
Bioactive surface-functionalized MXenes for biomedicine
This work reviews the surface modification strategies and biomedical applications of MXene, discusses the challenges, trends and prospects of MXenes nanomaterials, which provides information for enhancing the clinical translation of nanomedicine.
Nanoscale, 2025,17, 4854-4891
https://doi.org/10.1039/D4NR04260C
Engineering the next generation of MXenes: challenges and strategies for scalable production and enhanced performance
Optimization strategy of MXene scale preparation.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04560B
Holistic insights into carbon nanotubes and MXenes as a promising route to bio-sensing applications
Carbon nanotubes (CNTs) and MXenes are promising as targeted sensing agents in advanced functional materials. MXenes are more suitable for biosensing applications due to their versatility and compatibility with aquatic environments.
Nanoscale, 2024,16, 21216-21263
https://doi.org/10.1039/D4NR03008G

Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing
Used in hydrogels, patches, and smart bandages MXenes enhance antibacterial activity, promote tissue regeneration, and enable real-time monitoring, improving wound care and patient outcomes.
Nanoscale, 2024,16, 18684-18714
https://doi.org/10.1039/D4NR02843K
Sulphur-decorated Ti3C2 MXene structures as high-capacity electrode for Zn-ion batteries: a DFT study
MXene-based structures have gained tremendous attention in energy storage applications, especially in ion batteries due to their promising electrical conductivity and high energy storage properties.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05204H
Formation of hydrocarbons and carbon oxides in MXene reactions with water under varying oxidative conditions
This study explores the environmental stability of MXenes, revealing the formation of higher hydrocarbons and carbon oxides. It highlights methane dominance under reducing conditions and carbon oxide production under oxidative environments.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04937C
A modified MXene composite sensor with sulphur impurities for electrochemical detection of lead in the aqueous system
Representation of low cost MXene based electrochemical sensor for lead detection.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05021E
Investigation of the Mo2Ti2C3Tx MXene in the electrochemical immunosensing of the respiratory syncytial virus (RSV)
Schematic illustration of (A) the fabrication steps of the Mo2Ti2C3Tx MXene-based immunosensor and (B) its application in the electrochemical detection of the RSV antigen.
Nanoscale, 2025,17, 5161-5170
https://doi.org/10.1039/D4NR04333B
Bright yellow fluorescent N-doped Ti3C2 MXene quantum dots as an “on/off/on” nanoprobe for selective As3+ ion detection
Bright yellow fluorescent nitrogen-doped MXene quantum dots were synthesized and employed to detect As3+ and MBTZ via fluorescence “on/off/on” phenomenon.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04139A

Highly selective ethanol gas sensor based on CdS/Ti3C2Tx MXene composites
Sensing of hazardous gases has an important role in ensuring safety in a variety of industries as well as environments.
Nanoscale Adv., 2025,7, 1452-1463
https://doi.org/10.1039/D4NA00927D
In situ synthesis of a UIO-66-NH2@Ti3C2 composite for advanced electrochemical detection of acetaminophen
This research involved synthesizing a novel UIO-66-NH2@Ti3C2 composite through a one-step hydrothermal process, followed by calcination at 300 °C under argon and exploring its potential for the electrochemical detection of acetaminophen.
Nanoscale, 2025,17, 4444-4454
https://doi.org/10.1039/D4NR04388J
Impact of different 2D materials on the efficacy of photothermal and photodynamic therapy in 3D-bioprinted breast cancer
The convergence of nanotechnology and tissue engineering has paved the way for innovative cancer treatments that leverage the unique light absorption properties of nanomaterials.
Nanoscale, 2025,17, 3221-3235
https://doi.org/10.1039/D4NR05026F
Multipurpose triadic MXene/garlic/gellan gum-based architecture in the horizon of bone tissue regeneration
Introducing Ti3C2Tx nanosheets and garlic extract into a porous gellan gum scaffold could promote the hydrophilicity rate, mechanical strength, and antibacterial activity, providing a favorable structure for the growth and attachment of MG63 cells.
Nanoscale, 2025,17, 2528-2544
https://doi.org/10.1039/D4NR03995E
Ultrasensitive non-enzymatic electrochemical detection of paraoxon-ethyl in fruit samples using 2D Ti3C2Tx/MWCNT-OH
A highly sensitive non-enzymatic electrochemical sensor using a Ti3C2Tx/MWCNT-OH nanocomposite detects paraoxon-ethyl in fruit with high selectivity, a 0.1–100 μM range, and a 10 nM LOD, offering a sustainable alternative for pesticide monitoring.
Nanoscale, 2025,17, 2554-2566
https://doi.org/10.1039/D4NR04060K
Cr2TiC2Tx MXene as an adsorbent material in ultrasonic-assisted d-μ-solid phase extraction for trace detection of heavy metals
Cr2TiC2Tx MXene was used as an adsorbent for the trace determination of heavy metals in food samples, with LOD values of 0.09 and 1.9 ng mL−1, and dynamic ranges of 0.3–90 and 6–120 μg L−1 for cadmium and lead ions, respectively.
Nanoscale, 2025,17, 2545-2553
https://doi.org/10.1039/D4NR02556C
About this collection
Materials play a pivotal role in driving the progress of humanity. From the silicon age, when electronic and computer technologies revolutionized our lives, to the present, where we stand on the cusp of the age of nanomaterials, such as MXenes. MXenes represent a very large class of inorganic materials with an unparalleled diversity of structures and compositions. This sets them apart as one of the most significant recent discoveries in materials science.
These two-dimensional inorganic compounds consist of atomically thin layers of transition metal carbides, nitrides, or carbonitrides. Their versatile chemistry and unique and highly tuneable physicochemical properties have propelled them into myriad applications across various fields, ranging from energy storage to electronics and medicine.
We are delighted to invite you to contribute an article to our new special themed collection in Nanoscale on MXene chemistries in biology, medicine and sensing, which is being guest edited by Yury Gogotsi (Drexel University, USA), Lucia Gemma Delogu (University of Padua, Italy and Khalifa University, United Arab Emirates), Acelya Yilmazer (Ankara University, Turkey) and Maksym Pogorielov (Sumy State University, Ukraine and University of Latvia, Latvia).