Themed collection Lab on a Chip HOT Articles 2024

A cloud-based design and manufacturing platform for EWOD DMF.

Encapsulating molecular materials in lipid vesicles via microfluidics provides control over size, morphology, and compartmentalisation, enabling their use in cell biology research and for applications in biomedicine, synthetic biology, and beyond.

We develop an assay to measure glucose-stimulated insulin secretion from single cells using nanowell-in-microwells. Our results reveal the heterogeneity of single cell function for both stem cell derived β cells and human islet cells.

Exploiting non-faradaic signals from electrochemical sensors to track reagent flow in rapid diagnostic tests: towards smart tests with reduced user errors.

Pulsed ultrasound in an acoustofluidic device maintains sperm motility without compromising viability or DNA integrity, offering a safer, non-toxic alternative for assisted reproduction.

An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.

An enhanced heat transfer method based on the electrocapillary effect of eutectic gallium–indium alloy droplets for microfluidics is proposed.

A novel compact lens-free imager achieved high-throughput long-term monitoring within an incubator, demonstrating the quantification of the confluency of human iPS cells, epithelial-to-mesenchymal transition, and cardiomyocyte beating dynamics.

Polydopamine, a mussel-foot-inspired polymer, was implemented to facilitate the deposition of photothermally active gold via electroless deposition, and the coated surface was applied to achieve a light-triggered polymerase chain reaction on a chip.

Optimising, by tailored flows, the coupled ion transport in the proximity of selective nanopores multiplies by 300 the recovered osmotic power.

AI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models excel in microchip testing, underscoring AI's potential to improve precision medicine and POC diagnostics.

An advanced microfluidic platform integrated with a microelectrode array for the study of structural and functional adaptations of neural networks in response to localized perturbations.

A monolithic 3D-printed step-emulsification device is fabricated for scalable and robust production of high viscosity droplets.

Fully automated sample-to-answer ddPCR for virus quantification is implemented on a centrifugal platform with active pneumatic pumping comprising wireless heaters and miniaturized fluorescence imaging system.

We mapped and quantified sub-cellular distribution of antisense oligonucleotides in 3D and established spectroscopic components enabling precise detection of cuboidal hepatocytes in a liver-on-a-chip platform with advanced light microscopy methods.

This study introduces a microfluidic gut–brain axis-on-a-chip model that simulates exosome delivery from the gut to the brain using convective flow. Integrating real-time imaging with simulations, it advances exosome research.

The paper introduces a photobleaching strategy for producing multiple bead populations on flow cytometry to accelerate and facilitate the discovery of antibody-binding pairs using a pooled antibody cross-testing assay.

A human glymphatics-on-chip model reveals that monomeric and oligomeric amyloid-β cause distinct Alzheimer's disease pathophysiological characteristics in astrocytes.

Liquid phase synthesis methods coupled with advanced additive techniques, and combinatorial approaches create new possibilities in the design of gas analytical systems. Particular sensor combinations enhance the performance of analyte classification.

We report a microfluidic electrochemical immunosensor that employs a unique finger-actuated mixer for rapid (<25 min), ultrasensitive (∼5 pg mL⁻¹) measurements of protein biomarkers in human plasma using a smartphone-based diagnostic device.

Changes in the abundance of certain bacterial species within the colorectal microbiota correlate with colorectal cancer (CRC) development.

When droplets pass through constrictions, they exhibit a behavior akin to cellular pinocytosis, forming intricate multiple emulsions.

We develop a high-throughput droplet-based extracellular vesicle analysis (DEVA) assay for ultrasensitive quantification of EVs in plasma that are positive for both PD-L1 and tetraspanins.