Themed collection #MyFirstJMCB

A projected hip implant with the combination of a collared and FGM porous structure.

This review deliberates the current progress in organ bioprinting, including the heart, kidneys, liver, pancreas, and lungs. Challenges and future trends related to the biomanufacturing of living organs are discussed.

This article introduces the latest AD treatment techniques from three aspects: drug therapy, biological therapy and physical therapy. Nanoparticle-mediated therapeutics at nanomaterial–neural interfaces and biological systems are described in detail.

Schematic illustration of the comprehensive evaluation and advanced modification of PMMA cement in bone tumor treatment.

Virus-like particles (VLPs) are self-assembled supramolecular structures in nature for compartmentalization. We summarize the current progress of protein cage nanoreactors spanning multilength scales, and highlight the emerging field of VLP based nanoreactors for biomedical applications.

In this review, we delved into an elaborate exposition of different detection principles reliant on micro/nanomotors (MNMs), explore the challenges encountered by MNMs under distinct detection principles, and discuss potential future solutions.

The rational design and engineering strategies, employed in polypeptide/protein vesicles, from synthesis to assembly, for advanced biological and medical applications.

In Alzheimer's disease, AuNPs may reduce neuroinflammation by induction of macrophage polarization, reduction of pro-inflammatory cytokine expression, restraint of leukocyte adhesion, and reduction of oxidative stress.

This review summarizes the advances in biomaterial scaffolds with different functionalization strategies for bone tumors. It will provide a valuable reference for bone tumor clinical treatment.

This review discusses unique nanosystems combining taxanes with photosensitizers as multimodal chemo- and phototherapeutics for cancer treatment.

Application of nanomaterials in the diagnosis and treatment of BC.

Crafting integrated biomolecular circuits (IbC) via self-assembly of electronically active molecules using a “bottom-up” paradigm provides a potential solution to the technological challenges of the miniaturization of silicon-based electronics.

Thyroid cancer, the most common malignancy in the head and neck region, has shown an increasing incidence trend. With the continuous advancement of nanotechnology, nanomaterials hold great promise in providing diagnosis and treatment of thyroid cancer.

A comprehensive review of melanin's structure, identification methods, and biological activities, highlighting its potential for further development and diverse applications in various fields.

Intracellular cargo delivery is an important strategy for deciphering cell function, directing cell fate, and reprogramming cell behavior.

The synergistic effect of nanotopography and chemistry in modulating different stages of the foreign body response, impacting cell–protein–biomaterial interactions.

There are many native and engineered capsid-forming proteins which can self-assemble into different non-canonical structures. In this review, we categorise examples of structural polymorphism by their method of formation.

Fabricating high-performance nanoparticles (NPs) is currently a focus of researchers due to their manipulative size-dependent unique properties required to develop next-generation advanced systems.

Our regard to the use of chitin as a material has drastically changed since its discovery.

To address the problem of thrombosis, anticoagulant coatings have been developed for extracorporeal membrane oxygenation circuits. This article reviews commercial and novel anticoagulant coatings recently and proposes a new classification of them.

This review provides an overview of the latest research progress in mRNA structural optimization strategies and their delivery systems, and discusses key considerations for their future clinical use.

Materials research relating to bio-based polymers and composites has become the order of the day and several types of research are being undertaken on these materials.

Metal–organic frameworks (MOFs) hold great promise for widespread applications in biomedicine and nanomedicine.

Selenocysteine (SeCys) is the 21st genetically encoded amino acid present in proteins and is involved in various biological functions.

This paper reviews the essential properties of nucleic acid nanocarriers and modern additions to the field which have pushed the boundaries of nucleic acid usage.

Hydrogels with electrically conductive nanomaterials find numerous biomedical applications where conductivity is relevant, such as substrates for tissue engineering of electroactive cells, strain-sensitive sensors and platforms for drug delivery.

The development of hydrogels that can exhibit a transient response, fueled by enzymes, while also depleting the enzymatic activity of fuel, holds immense potential for sophisticated materials capable of dynamically intervening in biological events.

This study provides proof of charge complementarity-based inclusion complex formation between an engineered protein nanocage and an otherwise degradation-prone cargo protein in live bacterial cells.

A new strategy of PEGylation over core–shell MOFs of HKUST-1 and Cu-MOF-2 by a solvothermal method.

ELP hydrogels for co-delivery of aPD-L1 and GEM induced a robust antitumor immune response for potentiated immunotherapy.

This study investigated different secondary building units of iron-based metal–organic frameworks and discovered that when combined with an enzyme-encapsulating ZIF-90 PVP MOF, they could be sequentially employed for glucose detection purposes.

A biodegradable self-powered bacterial sensor made of carbohydrate protein interaction. The sensor offers a simple design and capable for rapid and effective detection of E. coli bacteria.

The study demonstrates how bioinspired peptides, selected via phage display, mimic sea urchin proteins, influencing the formation of CaCO₃ crystals. Charged peptides play a crucial role in shaping these crystals.

Ultrafast and sensitive detection of Staphylococcus aureus, a harmful Gram-positive human pathogenic bacterium, by two-dimensional layered materials continues to be a challenge. Here we present an ultrafast and selective detection of S. aureus bacterium using strong fluorescence emission of WS₂ QDs.

Four types of biomimicking radially graded scaffolds were designed and fabricated via digital light processing 3D printing. Graded gyroid–gyroid scaffolds exhibited better dimensional accuracy, compressive property, and cell proliferation rate.

The novel structure of the hollow gold shell has an ideal X-ray deposition capacity, which ensures the sensitizing effect of radiotherapy. The immunogenic cell death pathway is activated by NIR-II photothermal therapy in conjunction with radiotherapy.

Highly efficient, biocompatible low molecular mass organo/hydrogelators were designed and synthesized by one-pot Ugi multicomponent reactions as potential drug delivery carriers for metronidazole.

We developed and compared transparent micro electrocorticography arrays (μECoGs) to combine electrophysiology and functional imaging. PEDOT:PSS-based μECoGs had the best trade-off of material and physical properties for chronic in vivo experiments.

The release and accumulation of neutrophil extracellular traps (NETs) in the airway mucus barrier is prominent in cystic fibrosis. New biomaterial-based models are developed that mimic important aspects of NET-mediated pathobiology in cystic fibrosis.

Electrospun biomimetic scaffolds and their potency in in vivo wound healing.

Schematic representation of 3D Printed PCL/PEG artificial bile duct fabrication and in vivo promotion of biliary regeneration.

π–π stacking strategies can enhance the stability performance of delivery platforms but are often led to incomplete drug release performance, even with the help of crosslinking strategies. A collaborated strategy is proposed to improve drug release.

A dihydroartemisinin (DHA)-loaded semiconducting oligomer nanoparticle is designed for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy.

Pre-activation of SERS plasmonic substrate with UV light leads to the creation of long-lived charged states resulting in better attachment of proteins and an increase in the SERS chemical enhancement.

Photothermal therapy (PTT) is a noninvasive and effective thermal therapeutic approach.

Acyclic cucurbit[n]uril-based nanosponges could efficiently deliver temoporfin to cancer cells and enhance its efficacy in vivo.

Plasmonic hotspots and FRET induced fluorescence enhancement from fluorophore tagged flexible linear 1D ETE assembly of more than 100 gold nanorods has been achieved by DNA templated chemistry with amine modified probe DNAs.

Novel photo-oxidant nanoparticles (T-LD NPs) showed effective near-infrared fluorescence imaging of β amyloid (Aβ), and potent inhibition of Aβ fibrillation and fast disaggregation of mature Aβ fibrils by photo-oxygenation under laser irradiation.

An Fe(III)-incorporated porphyrin-based conjugated organic polymer is reported as a nanozyme for the efficient detection of glucose via intrinsic peroxidase activity and amperometric detection of H₂O₂.

Carbon dot (CD)-based nanozymes have great potential in antibacterial applications through the design of the structure.

We present a bench-top colloidal approach for fabricating three-lobed magnetic microrobots. These microrobots showed promising results for single-cell transportation in a fluid.

Granules obtained from 3D sphene scaffolds present similar biological response to natural bone in vitro.

We demonstrate the construction of hydrogel scaffolds for photosynthetic ethylene production using a bioinspired design combining TEMPO-oxidized cellulose nanofibers (TCNF) and a cereal plant hemicellulose called mixed-linkage glucan (MLG).

A novel PEC and ECL bifunctional biosensor for the sensitive and selective detection of miRNA-126 based on the AgNPs@V-PMOF Schottky heterojunction was constructed.

Currently, multidrug-resistant (MDR) infections are one of the most important threats, driving the search for new antimicrobial compounds.

An electrochemical–fluorescent bimodal sensor was successfully constructed by using a DNA–AgNCs signal tag with both electrochemical and fluorescent signals combined with a magnetic separation strategy.

Within hydrogen-bonded organic frameworks (HOFs), the stabilized charge transfer cocrystals, named TQC@PFC-1, exhibit high photothermal conversion efficiency in the NIR II region for photothermal therapy in both in vitro and in vivo settings.

This work illustrates a new method for preparing fluorescent amyloid nanofibers. The strategic fabrication mentioned in the study is highly relevant to the advancement of both fundamental and applied research in biological and materials sciences.

Plasmonic alloys were designed to assist the laser desorption/ionization process in mass spectrometry, for quantitative determination and reaction monitoring of biothiols.

Intravenous chemotherapy is standard treatment for many cancers but also produces off-target toxicity. We developed polymer–nucleobase composites that can capture chemotherapy drugs, potentially enabling endovascular devices to reduce side effects.

A versatile PLDD was developed with the light-triggered promotion of anti-tumor immunity and NIR-II fluorescence and PA imaging profiles, soaring the therapeutic effect and providing accurate spatiotemporal imaging for photothermal immunotherapy.

A mitochondria-targeted nanoplatform is developed to deplete intracellular copper ions and deliver DOX, consequently achieving prominent efficiency in tumor treatment with a combined copper-depletion therapy and DOX-mediated chemotherapy method.

3D printing-mediated microporous starch hydrogels loaded with Ca²⁺ coagulation factor showed great hemostatic performance and stimulation of wound healing.

A straightforward, one-pot, low-temperature hydrothermal method has been set up to transform calcium carbonate particles from oyster shell waste into hydroxyapatite micro/nanoparticles with osteoinductive properties.

Quaternized carbon dots prepared from citric acid and diallyl dimethyl ammonium chloride exhibit enhanced antibacterial activity against Gram-negative bacteria for the effective treating acute peritonitis with E. coli infection via injection.

Hydrogels with adaptable optical and mechanical characteristics show considerable promise for light delivery in vivo with neuroengineering applications.

Degradation behavior of dental composites in oral environments simulating gastroesophageal reflux was analysed. Further, thermodynamic and quantitative analyses of the composites uncovered their aqueous stabilities and degradation mechanisms.

Targeted delivery of ceria nanozymes depletes oxidative stress in inflammatory macrophage cells and alleviates gouty arthritis symptoms by suppressing inflammatory signals.

Mn(II)-based porous silica nanoparticle encapsulated Zn(II)-responsive MRI contrast agent has been investigated to examine the pathological condition of pancreatic β-cells whose functional efficiency is related to type-1 and type-2 diabetes mellitus.

Protein-based biomaterials, particularly amyloids, have sparked considerable scientific interest in recent years due to their exceptional mechanical strength, excellent biocompatibility and bioactivity.