Themed collection Nanoscale 2025 Emerging Investigators

Cu-based bimetallic catalysts for electrochemical CO2 reduction: before and beyond the tandem effect
Cu-based bimetallic catalysts show enhanced electrochemical CO2 reduction performance via the tandem effect. This review traces their progress, highlighting design advances, mechanisms, and challenges to guide efficient CO2 conversion.
Nanoscale, 2025,17, 9057-9071
https://doi.org/10.1039/D4NR04790G
Flexible fibrous electrodes for implantable biosensing
This review explores advancements, applications, challenges, and future prospects of flexible fibrous electrodes for implantable biosensing, highlighting their potential in biomedical monitoring and human–machine interfaces. Images reproduced with permission, full details in paper.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04542D

Characterisation of polymeric nanoparticles for drug delivery
Polymeric nanoparticles represent an innovative approach to drug delivery, particularly for addressing complex diseases like cancer.
Nanoscale, 2025,17, 7738-7752
https://doi.org/10.1039/D5NR00071H
External strategies for enhanced sensing performance of self-powered polyvinylidene fluoride-based sensors
External strategies such as electrode design, stress/heat transfer improvements, microstructure optimization, and multifunctional synergy show great potential for improving sensing performance of PVDF-based sensors. Images reproduced with permission, full details in paper.
Nanoscale, 2025,17, 6981-6992
https://doi.org/10.1039/D4NR05200E

Sustainable nanofibrous membranes for air filtration, water purification and oil removal
The increasing demand for sustainable solutions to address environmental and energy challenges has driven the development of advanced materials. This paper highlights recent advancements in the development of sustainable nanofibrous membranes.
Nanoscale, 2025,17, 6427-6447
https://doi.org/10.1039/D4NR04673K
Leveraging the dual role of ROS in liver diseases with nanomaterials: clearing and amplifying for therapy
The dual role of ROS in liver diseases, and the potential of nanomaterials with catalytic activity for therapeutic applications are examined.
Nanoscale, 2025,17, 3688-3697
https://doi.org/10.1039/D4NR04469J
NIR-II upconversion nanomaterials for biomedical applications
This review provides a comprehensive overview of recent biomedical applications of upconversion nanomaterials specifically within the near-infrared two-region (NIR-II) window (1000–1700 nm).
Nanoscale, 2025,17, 2985-3002
https://doi.org/10.1039/D4NR04445B

Advances in integrated power supplies for self-powered bioelectronic devices
The emerging integrated power supplies for self-powered bioelectronic devices over the past few years are summarized. Additionally, the challenges and future perspectives in self-powered device design and manufacturing are also indicated.
Nanoscale, 2025,17, 2423-2437
https://doi.org/10.1039/D4NR04645E

Design strategies and performance enhancements of PVDF-based flexible electrolytes for high-performance all-solid-state lithium metal batteries
Lithium metal is considered one of the most promising anode materials for lithium batteries due to its high theoretical specific capacity (3860 mA h g−1) and low redox potential (−3.04 V).
Nanoscale, 2025,17, 2408-2422
https://doi.org/10.1039/D4NR04583A
Organic semiconductor bulk heterojunctions for solar-to-chemical conversion: recent advances and challenges
This minireview highlights recent progress in BHJ-based photoelectrochemical cells and photocatalysts for solar-to-chemical conversions.
Nanoscale, 2025,17, 1889-1921
https://doi.org/10.1039/D4NR03938F
Advanced applications in enzyme-induced electrospun nanofibers
Guidelines for tailored enzyme-induced electrospun nanofiber immobilization techniques: aligning fabrication methods with future application requirements.
Nanoscale, 2024,16, 19606-19619
https://doi.org/10.1039/D4NR03404J
Design of engineered nanoparticles for biomedical applications by computational modeling
Engineered nanoparticles exhibit superior physicochemical, antibacterial, optical, and sensing properties, rendering them attractive for biomedical applications. Multiscale modeling aids in understanding and optimizing these properties.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05199H
Diverse applications of DNA origami as a cross-disciplinary tool
DNA origami provides precise addressable self-assembly templates, demonstrating the tremendous potential of DNA origami technology in promoting interdisciplinary integration and driving technological progress.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04490H
More than a delivery system: the evolving role of lipid-based nanoparticles
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR04508D
Self-assembled monolayer functionalized metal oxides: a path toward highly selective and low-power consuming gas sensors
The emerging functionalization strategy of self-assembled monolayers (SAMs) offers transformative potential for enhancing the performance of nanostructured metal oxides (MOXs)-based gas sensors.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05307A
Strategies for industrial-grade seawater electrolysis: from electrocatalysts and device design to techno-economic analysis
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05520A
Recent progress on transition metal dichalcogenide-based composites for cancer therapy
In this review, we present the recent progress on transition metal dichalcogenide-based composites, including their typical categories, key fabrication strategies, and transformative roles in the field of cancer therapy.
Nanoscale, 2025,17, 7552-7573
https://doi.org/10.1039/D4NR05510A

Recent advances in the fundamentals and in situ characterizations for mechanics in 2D materials
This review involves advances in the mechanics of 2D materials, including measurement methods, sample transfer, materials design, and mechanisms covering the impact of defects and thickness for highly-bendable 2D materials.
Nanoscale, 2025,17, 7574-7599
https://doi.org/10.1039/D4NR05171H
Modulation anisotropy of nanomaterials toward monolithic integrated polarization-sensitive photodetectors
This review provides an overview of linear, circular, and full-Stokes photodetectors, discussing how to simplify their design from complex to simple. Images by permission of: RSC 2021, WLY 2023, Optica Publishing Group 2016 and ACS 2020.
Nanoscale, 2025,17, 7533-7551
https://doi.org/10.1039/D4NR05034G

Flexible, wearable mechano-acoustic sensors for body sound monitoring applications
This review highlights recent advances in flexible, wearable mechano-acoustic sensors for body sound measurement, emphasizing their potential for ambulatory health monitoring. Created in BioRender. Dang, T. (2025) https://BioRender.com/l15d184.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05145A
Recent advances in flexible multifunctional electrochromic devices
This review comprehensively summarizes the recent development of flexible multifunctional electrochromic devices, including energy harvesting, energy storage, multicolor displays, and smart windows.
Nanoscale, 2025,17, 6919-6937
https://doi.org/10.1039/D4NR04074K

Progress in Computational Methods and Mechanistic Insights on the Growth of Carbon Nanotubes
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05487C
Nanoscale high-entropy alloys for solar and thermal applications
This review highlights the advantages of non-annealing synthesis, emphasizing the importance of in situ characterization, multi-level simulations and machine learning to accelerate photo-/thermocatalytic research in nanoscale high-entropy alloys.
Nanoscale, 2025,17, 6266-6286
https://doi.org/10.1039/D4NR04697H
Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery
This review systematically describes the preparation of poly(amino acids) and peptides, and their use in drug loading for various diseases, offering insights for research and clinical applications of degradable biomedical polymers.
Nanoscale, 2025,17, 3549-3584
https://doi.org/10.1039/D4NR04481A
Strategic design of emerging (K,Na)NbO3-based perovskites for high-performance piezocatalysis and photo-piezocatalysis
This comprehensive review of (K,Na)NbO3-based perovskites explores design strategies, mechanisms, and applications in piezocatalysis and photo-piezocatalysis for sustainable environmental and energy solutions.
Nanoscale, 2025,17, 2931-2960
https://doi.org/10.1039/D4NR04415K
Patterning technologies of quantum dots for color-conversion micro-LED display applications
A comprehensive summary of patterning technologies of quantum dots for construction of color-conversion layers in full-color micro-LED displays is provided.
Nanoscale, 2025,17, 1764-1789
https://doi.org/10.1039/D4NR03925D
Single atoms meeting 2D materials: an excellent configuration for photocatalysis
The state-of-art progress in single-atom tuned two-dimensional materials is reviewed to clarify the distinctive advantages in photocatalysis and present the crucial structure–activity relationship for improved performance.
Nanoscale, 2024,16, 22077-22098
https://doi.org/10.1039/D4NR03787A
Rational nanoparticle design for efficient biomolecule delivery in plant genetic engineering
Nanoparticle-mediated approaches to plant genetic engineering represent key advances in agriculture, offering benefits beyond conventional techniques. This review discusses essential nanoparticle design considerations to optimize delivery efficiency.
Nanoscale, 2024,16, 21264-21278
https://doi.org/10.1039/D4NR03760J
Recent advances in tungsten oxide-based chromogenic materials: photochromism, electrochromism, and gasochromism
Applications of WOx in photochromic, electrochromic, and gasochromic materials and devices.
Nanoscale, 2024,16, 21279-21293
https://doi.org/10.1039/D4NR03781B
New paradigms of 2D layered material self-driven photodetectors
The burgeoning initiatives implementing self-driven 2D layered material photodetectors have been presented, heralding new avenues for the next-generation integrated and miniaturized optoelectronic industry.
Nanoscale, 2024,16, 20811-20841
https://doi.org/10.1039/D4NR03543G
Developments, challenges and future trends in advanced sustainable machining technologies for preparing array micro-holes
The use of array micro-holes is becoming increasingly prevalent across a range of industries, including the aerospace, automotive, electronics, medical and chemical industries.
Nanoscale, 2024,16, 19938-19969
https://doi.org/10.1039/D4NR02910K

Functionalization dependent biodegradability of two-dimensional antimonene by peroxidases: impact on immune modulation
The study reports the biodegradability of 2D antimonene sheets by human peroxidase isolated from the primary immune cells, neutrophils and the impact of functionalization of antimonene with cyclodextrin on biodegradation and immune modulation.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04786A
FRET-driven hybrid polymer–perovskite matrices for efficient pure-red emission
Enhancing the pure-red perovskite emission via Förster Resonance Energy Transfer (FRET) in a polymer–perovskite blend system, leveraging optimal spectral overlap between polymer emission and perovskite absorption.
Nanoscale, 2025,17, 7753-7759
https://doi.org/10.1039/D4NR05253F

SnSb as a long cycle life anode material for sodium-ion batteries enabled by a high concentration electrolyte
The performance of a SnSb Na-ion battery anode composed of nanolayers of Sn and Sb is reported, wherein the cycle life was significantly enhanced by the use of a high concentration electrolyte.
Nanoscale, 2025,17, 6460-6465
https://doi.org/10.1039/D4NR03820G

Slippery liquid-like surfaces as a promising solution for sustainable drag reduction
Fluid slip and drag reduction induced by durable slippery liquid-like surfaces (SLLSs) made from flexible polymers.
Nanoscale, 2025,17, 6448-6459
https://doi.org/10.1039/D4NR04507F
Nanoparticle-assembled interconnected PbO1.44 hollow spheres enabled by PVP-driven transformation of β-PbO2 and self-sacrificial templating for superior lithium storage
Nanoparticle-assembled interconnected PbO1.44 hollow spheres (NAHSs) were crafted by a robust strategy of PVP-driven transformation of β-PbO2 microspheres (MSs) combined with a self-sacrificial templating mechanism for superior lithium storage.
Nanoscale, 2025,17, 3023-3034
https://doi.org/10.1039/D4NR04763J

Exfoliation of triazole-based C3N4.8, C3N6, and C3N7 nanosheets for efficient photocatalytic ammonia production
Triazole-based C3N7 nanosheets exhibit excellent photocatalytic ammonia production performance, attributed to their inherent properties of an optimised conduction band position and efficient charge separation.
Nanoscale, 2025,17, 2438-2443
https://doi.org/10.1039/D4NR03639E
Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes
CLASSIC is a label-free DNA detection platform with single-nucleotide specificity and attomolar sensitivity. This assay offers rapid and sequence-specific DNA analysis through single-strand conversion and split light-up aptamer probes.
Nanoscale, 2024,16, 20067-20072
https://doi.org/10.1039/D4NR01638F
Protecting Li-metal anode with LiF-enriched solid electrolyte interphase derived from a fluorinated graphene additive
An LiF-enriched (composition-wise) and organic/inorganic uniform-distributed (structure-wise) SEI film architecture was derived by fluorinated graphene (F-Gr) sacrificial additive to promote efficient Li-metal protection.
Nanoscale, 2024,16, 19633-19641
https://doi.org/10.1039/D4NR02877E
Simultaneous formation of helical and sheet-like assemblies from short azapeptides enables spontaneous resolution
Bioinspired 1D helical and 2D sheet-like assemblies are combined to form a 3D homochiral assembly that allows spontaneous resolution.
Nanoscale, 2024,16, 19221-19227
https://doi.org/10.1039/D4NR02872D
3D-Printed Kirigami-Inspired Asymmetric Dressings: Custom Elasticity and Self-Pumping for Enhanced Wound Healing
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05506C

In situ growth of layered 1T-MoS2 onto carbon nanofibers as a strategy towards advanced hybrid materials for electrochemical energy storage and catalysis
We designed 1T-MoS2/CNFs with different thicknesses of MoS2 layer, which affect conductivity, charge storage and transfer. Optimized 1T-MoS2/CNFs enhance supercapacitance and hydrogen evolution performance, offering a strategy for energy devices.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00711A
Enhanced electromechanical response in Dy3+-doped PNN–PZT relaxor ferroelectrics
A high piezoelectricity and excellent temperature stability were achieved in PNN–PZT relaxor ferroelectrics, outperforming those of other typical piezoceramics.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04839C
Self-assembled colloidal glass with 100% lanthanide nanocrystal loading for high-resolution X-ray imaging
A new class of bright, transparent colloidal glasses with 100% nanoparticle loading was developed via self-assembly, addressing the longstanding trade-offs between optical transparency and scintillation efficiency in X-ray imaging technology.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05213G

Ultrasensitive detection of 2,4-dichlorophenoxyacetic acid by inhibiting alkaline phosphatase immobilized onto a highly porous gold nanocoral electrode
Herein, we describe the design and implementation of an ultrasensitive enzyme inhibition-based biosensor for 2,4-dichlorophenoxyacetic acid (2,4-D) detection.
Nanoscale, 2025,17, 9197-9204
https://doi.org/10.1039/D4NR04857A
High-performance aqueous copper-ion batteries based on iron hexacyanoferrate cathodes for enhanced energy storage
The intercalation/deintercalation mechanism of copper ions in iron hexacyanoferrate (FeHCF) was explored, and an aqueous battery with a voltage range of 1.6–2.5 V was prepared. These findings highlight the potential of FeHCF-based aqueous batteries.
Nanoscale, 2025,17, 9213-9221
https://doi.org/10.1039/D4NR05203J

Structural diversity dependent cation incorporation into magnetic Cr–Se nanocrystals
We report the colloidal synthesis of Cr–Se nanocrystals with tunable morphologies for cation exchange reactions to produce metal selenide nanocrystals.
Nanoscale, 2025,17, 9222-9231
https://doi.org/10.1039/D4NR05035E
Glass-confined carbon dots: transparent afterglow materials with switchable TADF and RTP
The confined synthesis of carbon dots (CDs) in solid matrixes is a promising avenue for developing new afterglow materials.
Nanoscale, 2025,17, 9144-9153
https://doi.org/10.1039/D4NR04835K
Ultra-confined plasmons reveal moiré patterns in a twisted bilayer graphene–talc heterostructure
This work reveals ultra-confined SP3 modes and the transition from plasmonic waves to moiré patterns in TBG, highlighting solitonic boundaries as reflective channels for plasmonic waves. Image created via Blender Foundation (http://www.blender.org).
Nanoscale, 2025,17, 9205-9212
https://doi.org/10.1039/D4NR04532G

Nanostructured films from poly(3-hexylthiophene)-graft-poly(ε-caprolactone) as light-responsive generators of reactive oxygen species
Photoactive films made from poly(3-hexylthiophene)-graft-poly(ε-caprolactone) copolymers with tunable nanostructured morphologies through thermo-oxidation, modulating reactive oxygen species (ROS) generation upon photostimulation.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00027K

Enzyme-free optical detection of uric acid using corona phase molecular recognition in near-infrared fluorescent single-walled carbon nanotubes
DNA-functionalized single-walled carbon nanotubes enabled a point-of-care uric acid testing in human urine with a robust NIR fluorescence response without an enzyme through corona phase molecular recognition.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05046K

Spectroscopic evidence of intra-unit-cell charge redistribution in a charge-neutral magnetic topological insulator
Intra-unit-cell charge imbalance in the charge-neutral Sb-doped MnBi6Te10 crystal leads to a nanoscale p–n junction, resulting in the multiple surface photovoltage effects at the boundaries of crystal domains in time-resolved ARPES measurements.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04812A
Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging
Through rational surface engineering of ultrasmall NIR-II luminescent gold nanoclusters, brain glioblastoma-targeted NIR-II photoluminescence imaging has been achieved.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05158K

Pushing the Boundary of the Stability and Band Gap Pareto Front by Going Towards High-Entropy Perovskites
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05013D

PFAS self-assembly and adsorption dynamics on graphene: molecular insights into chemical and environmental influences
This study offers atomistic insights into the adsorption of per- and polyfluoroalkyl substances (PFAS) on graphene, highlighting how the stability of adsorbed PFAS is influenced by fluoroalkyl chain length, headgroup characteristic, and pH condition.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04995K

Colloidal gold-palladium-platinum alloy nanospheres with tunable compositions and defined numbers of atoms
In this study, we demonstrate that the combination of seed-mediated growth routes with pulsed laser irradiation produces high-quality colloidal AuPdPt alloy nanocrystals featuring spherical shapes, tunable compositions, and defined numbers of atoms.
Nanoscale, 2025,17, 8577-8587
https://doi.org/10.1039/D4NR04898A
Effect of channel patterning precision on the performances of vertical OECTs
Channel patterning precision in vOECTs enables efficient modulation of key transistor parameters, including drain current, transconductance, transient times, etc.
Nanoscale, 2025,17, 8634-8641
https://doi.org/10.1039/D4NR05239K

Self-healing and highly adhesive conductive polydimethylsiloxane-based elastomers for chronic epilepsy monitoring
A self-healing and highly adhesive conductive electrode was fabricated using crosslinked block PDMS-based elastomer–doped CNTs for chronic epilepsy monitoring.
Nanoscale, 2025,17, 8624-8633
https://doi.org/10.1039/D5NR00171D
Magnetically targeted delivery of probiotics for controlled residence and accumulation in the intestine
We developed a magnetically targeted delivery strategy to achieve controlled probiotic residence in the intestine based on electrostatic interactions between electropositive magnetic nanoparticles and electronegative probiotics.
Nanoscale, 2025,17, 8588-8598
https://doi.org/10.1039/D4NR04753B
Unraveling the infrared detection properties of Bi2Te3 depending on thickness under the semiconductor and metal surface states
As the thickness of the Bi2Te3 film increases, its photoelectric response mechanism changes from a photoconductive effect to a photobolometric effect.
Nanoscale, 2025,17, 8524-8532
https://doi.org/10.1039/D4NR05067C

Combined effects of electrode morphology and electrolyte composition on single H2 gas bubble detachment during hydrogen evolution reaction
Depending on the direction of the Marangoni effects, gas bubble locations and consequently the force balance determining gas bubble detachment can vary significantly.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00234F
Tuning Nanoscale Tribological Characteristics of Thermally Evaporated Transparent Polyaniline-Graphene Nanocomposite Thin Films
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05482B
Epitaxial growth of antiferromagnetic MnBi2Te4/CdTe heterostructures on GaAs(001) using molecular beam epitaxy: structure and electronic properties
MnBi2Te4 is one of the most recent materials that integrates the class of topological quantum materials exhibiting topological insulating properties and magnetic ordering to investigate topological quantum states and design novel spintronic devices.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05042H
Fluffy mesoporous Al2O3 supported Ag–In2O3 schottky junction catalysts for selective hydrogenation of C
O of α,β-unsaturated aldehydes
Highly selective hydrogenation of CO of α,β-unsaturated aldehydes to unsaturated alcohols was achieved over a fluffy mesoporous Al2O3-supported Ag–In2O3 Schottky junction catalyst.
Nanoscale, 2025,17, 7837-7843
https://doi.org/10.1039/D4NR05518G
Demonstration of 300 mm RF-SOI wafers fabricated by layer transfer technology
The key fabrication technologies for domestic 300 mm wafer-level RF-SOI are demonstrated for the first time. The 300 mm RF-SOI wafers with less than 3 Å Top-Si roughness and −95 dB m 2nd harmonic distortion at 900 MHz were successfully fabricated.
Nanoscale, 2025,17, 7830-7836
https://doi.org/10.1039/D4NR04439H
Ionizable lipid nanoparticles enhance lung delivery of gold nanoclusters for improving acute lung injury alleviation
Ionizable lipid nanoparticles (iLNPs) were used as lung-delivery carriers to improve the alleviating efficiency of anti-inflammatory gold-nanoclusters in acute lung injury.
Nanoscale, 2025,17, 7888-7897
https://doi.org/10.1039/D4NR05415F
Rational synthesis of carbon-rich hollow carbon nitride spheres for photocatalytic H2O2 production and Cr(VI) reduction
Hollow carbon nitride spheres with a well-designed architecture and excellent optical properties serve as promising polymers for high-value chemical production and heavy metal treatment.
Nanoscale, 2025,17, 7856-7864
https://doi.org/10.1039/D4NR05501B

Harnessing DFT and machine learning for accurate optical gap prediction in conjugated polymers
Bridging the gap between DFT-calculated and experimental optical gap of conjugated polymers using machine learning, side-chain features, and a modified oligomer model.
Nanoscale, 2025,17, 7865-7876
https://doi.org/10.1039/D4NR03702B
Nanoparticles alter locust development and behaviour
The image illustrates the effect of nanoparticle-treated lettuce on locusts, showing their initial avoidance, eventual feeding, and subsequent death, suggesting a potential pest control strategy.
Nanoscale, 2025,17, 7844-7855
https://doi.org/10.1039/D4NR04993D
Self-supporting poly(3,4-ethylenedioxythiophene) and Fe3C Co-decorated electrospun carbon nanofibers as Li2S supporters for lithium–sulfur batteries
The PEDOT and Fe3C co-decorated carbon nanofibers provide a fast electron transfer pathway and high catalytic activity for sulfur reduction reactions, which can significantly improve the cyclic stability of lithium sulfur batteries.
Nanoscale, 2025,17, 7877-7887
https://doi.org/10.1039/D4NR04989F
About this collection
Nanoscale is proud to present this themed collection highlighting 2025’s rising stars of nanoscience and nanotechnology research, which gathers the very best work from researchers in the early stages of their independent career.
Each contributor was recommended by experts in their fields for carrying out work with the potential to influence future directions in nanoscience and nanotechnology. Congratulations to all the featured researchers on their important work in the field so far!