On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics
Carbonate radical anion, not hydroxyl radical, is the principal reactive oxygen species generated from endogenous oxidative stress endowing epigenetic features to guanine oxidation products in DNA.
Translational control of gene function through optically regulated nucleic acids
Gene function can be precisely controlled with light-responsive nucleic acids.
Arrow pushing in RNA modification sequencing
Methods to accurately determine the location and abundance of RNA modifications are critical to understanding their functional role.
Biosensing with DNAzymes
This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics.
Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues
Understanding and optimization of the photophysics of fluorescent nucleoside analogues are critical for their applications in probing the structure and dynamics of nucleic acids, and studying their interactions with ligands and biomolecules.
Recent progress in non-native nucleic acid modifications
While Nature harnesses RNA and DNA to store, read and write genetic information, the inherent programmability, synthetic accessibility and wide functionality of these nucleic acids make them attractive tools for use in a vast array of applications.
Review Article
Covalent labeling of nucleic acids
Labeling of nucleic acids is required for many studies aiming to elucidate their functions and dynamics in vitro and in cells.
Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells
This review provides the biophysicochemical background and recent advances in stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells.
Genetic alphabet expansion technology by creating unnatural base pairs
Recent advancements in the creation of artificial extra base pairs (unnatural base pairs, UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet expansion technologies.
Review Article
Next-generation DNA damage sequencing
DNA damage sequencing strategies.
Review Article
Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes
This review juxtaposes common versus distinct structural and functional strategies that are applied by aptamers, riboswitches, and ribozymes/DNAzymes.
Review Article
Small molecule recognition of disease-relevant RNA structures
Targeting RNAs with small molecules, a new frontier in drug discovery and development.
Tutorial Review
Nucleic acid constructs for the interrogation of multivalent protein interactions
Sequence-programmed self-assembly provides multivalent nucleic acid–ligand constructs used as tailor-made probes for unravelling and exploiting the mechanisms of multivalency-enhanced interactions on protein receptors.
About this collection
Guest Edited by Andrea Rentmeister (University of Münster, Germany), Scott Silverman (University of Illinois, USA) and Yitzhak Tor (University of California San Diego, USA), this Themed Collection covers all chemistry related aspects of nucleic acid research.