Themed collection Food & Function Review Articles 2023
Research progress in the treatment of inflammatory bowel disease with natural polysaccharides and related structure–activity relationships
Inflammatory bowel disease (IBD) comprises a group of highly prevalent and chronic inflammatory intestinal tract diseases caused by multiple factors.
Food Funct., 2024,15, 5680-5702
https://doi.org/10.1039/D3FO04919A
Physiologic effects of the maqui berry (Aristotelia chilensis): a focus on metabolic homeostasis
The present work highlights preclinical and clinical studies assessing the cardiometabolic benefits of maqui berry supplementation and provides a prospective outlook on development of novel maqui-based therapeutics for metabolic diseases.
Food Funct., 2024,15, 4724-4740
https://doi.org/10.1039/D3FO02524A
Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet
Hyperglycemia has become a global health problem due to changes in diet and lifestyle.
Food Funct., 2024,15, 2381-2405
https://doi.org/10.1039/D3FO04761J
Are oilseeds a new alternative protein source for human nutrition?
Processed oilseeds, combined with plant proteins, show potential as a protein source. They may have health benefits, but more clinical data are needed for confirmation.
Food Funct., 2024,15, 2366-2380
https://doi.org/10.1039/D3FO05370A
A systematic review of ginsenoside biosynthesis, spatiotemporal distribution, and response to biotic and abiotic factors in American ginseng
American ginseng (Panax quinquefolius) has gained recognition as a medicinal and functional food homologous product with several pharmaceutical, nutritional, and industrial applications.
Food Funct., 2024,15, 2343-2365
https://doi.org/10.1039/D3FO03434H
Gut–brain communication mediates the impact of dietary lipids on cognitive capacity
The effects of dietary lipids on cognition, both positive and negative, are mediated through the gut–brain axis by modulating metabolic, immune, neural, and endocrine pathways.
Food Funct., 2024,15, 1803-1824
https://doi.org/10.1039/D3FO05288E
Effects and mechanisms of anti-diabetic dietary natural products: an updated review
Dietary natural products could ameliorate diabetes via inhibiting carbohydrate hydrolyzing enzymes, exerting antioxidant, anti-inflammatory and anti-glycation effects, activating the PI3K/AKT pathway, modulating the gut microbiota, and so on.
Food Funct., 2024,15, 1758-1778
https://doi.org/10.1039/D3FO04505F
A review of the functional activities of chia seed and the mechanisms of action related to molecular targets
Chia seeds regulate glucose, fat metabolism and alleviate inflammation by up- or down-regulating key gene targets in MAPK, AMPK, TGF-β, PPAR-γ, NF-κB, and IRS mediated insulin signaling pathways. However, some mechanisms of action are still unknown and require speculation and research.
Food Funct., 2024,15, 1158-1169
https://doi.org/10.1039/D3FO02197A
Differences in carotid to femoral pulse wave velocity and carotid intima media thickness between vegetarian and omnivorous diets in healthy subjects: a systematic review and meta-analysis
Our results support the inclusión ofa well-balancedvegetariandietarypatternin the preventionand managementofcardiovascular diaseses.
Food Funct., 2024,15, 1135-1143
https://doi.org/10.1039/D3FO05061K
The role and impact of abnormal vitamin levels in autism spectrum disorders
This is a review of several vitamins (A, B, C, D, E, and K) that have been closely linked to the development of autism, exploring their mechanisms of action and significance in the prevention, mitigation, and treatment of autism.
Food Funct., 2024,15, 1099-1115
https://doi.org/10.1039/D3FO03735E
The association of gluten-free diet with thyroid autoimmunity in patients with celiac disease: a meta-analysis
GFD is positively associated with thyroid autoimmunity in CD patients that are children (<14 years).
Food Funct., 2024,15, 1089-1098
https://doi.org/10.1039/D3FO01573D
Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives
Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and a range of concurrent symptoms, imposing significant public health and economic burdens on society.
Food Funct., 2024,15, 1116-1134
https://doi.org/10.1039/D3FO02307A
Iron deficiency anemia: a critical review on iron absorption, supplementation and its influence on gut microbiota
The review comprehensively examines the intricate regulation of iron uptake and metabolism in the human body, shedding light on the essential role of various transporters and hormones in maintaining human health.
Food Funct., 2024,15, 1144-1157
https://doi.org/10.1039/D3FO04644C
Fatty acid isomerism: analysis and selected biological functions
The biological functions of fatty acids and the lipids in which they are esterified are determined by their chain length, double bond position and geometry and other structural motifs such as the presence of methyl branches.
Food Funct., 2024,15, 1071-1088
https://doi.org/10.1039/D3FO03716A
Effects of Vaccinium berries (blueberries, cranberries and bilberries) on oxidative stress, inflammation, exercise performance, and recovery – a systematic review
Evaluation of current clinical evidence on the effect of (poly)phenol-rich Vaccinium berries for sports nutrition.
Food Funct., 2024,15, 444-459
https://doi.org/10.1039/D3FO04435A
Non-starch polysaccharides from kidney beans: comprehensive insight into their extraction, structure and physicochemical and nutritional properties
The review critically discusses current insights into the physicochemical properties of bioactive molecules in kidney beans and focus on current knowledge of NSP structure and function on intestinal health and metabolism.
Food Funct., 2024,15, 62-78
https://doi.org/10.1039/D3FO03801G
Ingredients, structure and reconstitution properties of instant powder foods and the potential for healthy product development: a comprehensive review
The structure of instant powder foods is significantly influenced by their ingredients. Instant powder foods potentially can be formulated with functional or beneficial compounds to provide health benefits.
Food Funct., 2024,15, 37-61
https://doi.org/10.1039/D3FO04216B
Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review
Possible mechanisms involved in the regulation of diabetic kidney disease by garlic supplements.
Food Funct., 2024,15, 12-36
https://doi.org/10.1039/D3FO02407E
Estrogen receptor-mediated health benefits of phytochemicals: a review
Phytochemicals can provide health benefits via targeting estrogen receptors.
Food Funct., 2023,14, 10681-10699
https://doi.org/10.1039/D3FO04702D
Total and different dietary fiber subtypes and the risk of all-cause, cardiovascular, and cancer mortality: a dose–response meta-analysis of prospective cohort studies
We aimed to conduct a comprehensive review of the association between dietary fiber and the risk of mortality.
Food Funct., 2023,14, 10667-10680
https://doi.org/10.1039/D2FO04024G
Research progress on ginger polysaccharides: extraction, purification and structure–bioactivity relationship
Ginger is a widespread source of herbal medicine and traditional spices.
Food Funct., 2023,14, 10651-10666
https://doi.org/10.1039/D3FO03552B
Recent advances in oral delivery systems of resveratrol: foreseeing their use in functional foods
Herein, we review the current state-of-the-art on the use of micro- and nano-delivery systems, a possible solution to some of the drawbacks associated with the incorporation of resveratrol in foods.
Food Funct., 2023,14, 10286-10313
https://doi.org/10.1039/D3FO03065B
Nutritional composition, health-promoting effects, bioavailability, and encapsulation of tree peony seed oil: a review
TPSO stands out not only for its abundance of n-3 PUFAs but also for the presence of various important minor components that offer diverse health benefits. TPSO holds great potential as a superior oil that deserves global recognition and promotion.
Food Funct., 2023,14, 10265-10285
https://doi.org/10.1039/D3FO04094A
The sources, properties, extraction, biosynthesis, pharmacology, and application of lycopene
Lycopene is an important pigment with an alkene skeleton from Lycopersicon esculentum, which is also obtained from some red fruits and vegetables.
Food Funct., 2023,14, 9974-9998
https://doi.org/10.1039/D3FO03327A
Protein-based nutritional strategies to manage the development of diabetes: evidence and challenges in human studies
Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases in modern society, governed by both genetic and environmental factors, such as nutritional habits. Dietary habits have a relevant impact on its development.
Food Funct., 2023,14, 9962-9973
https://doi.org/10.1039/D3FO02466K
Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of in vivo studies
Steps of the NLRP3 inflammasome activation pathway where some selected polyphenols have shown a positive modulatory effect on different cardiometabolic alterations.
Food Funct., 2023,14, 9534-9553
https://doi.org/10.1039/D3FO03015F
The effect of n-3 polyunsaturated fatty acid supplementation on cognitive function outcomes in the elderly depends on the baseline omega-3 index
Preclinical studies have shown the benefits of n-3 polyunsaturated fatty acid (n-3 PUFA) on dementia and cognitive impairment, yet the results of clinical randomized controlled trials (RCTs) performed to date are conflicting.
Food Funct., 2023,14, 9506-9517
https://doi.org/10.1039/D3FO02959J
Critical review of the phytochemical profiles and health-promoting effects of the edible mushroom Armillaria mellea
Research on the nutritional and medicinal properties of wild edible mushrooms has witnessed a significant surge in recent years.
Food Funct., 2023,14, 9518-9533
https://doi.org/10.1039/D3FO02334F
Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms
The synthesis and metabolism of bile acids (BAs) have been implicated in various metabolic diseases, including obesity and diabetes.
Food Funct., 2023,14, 9486-9505
https://doi.org/10.1039/D3FO02471G
Effect of processing methods and storage on the bioactive compounds of black rice (Oryza sativa L.): a review
Compared to brown and white rice, black rice is rich in bioactive components, including γ-oryzanols, γ-aminobutyric acid, phenolic compounds, and anthocyanins, which makes it highly valuable for development and use.
Food Funct., 2023,14, 9100-9122
https://doi.org/10.1039/D3FO02977H
Biogenic engineered nanomaterials for enhancing bioavailability via developing nano-iron-fortified smart foods: advances, insight, and prospects of nanobionics in fortification of food
Iron deficiency is a significant cause of iron deficiency anemia (IDA).
Food Funct., 2023,14, 9083-9099
https://doi.org/10.1039/D3FO02473C
Emerging trends and applications of metabolomics in food science and nutrition
The study of all chemical processes involving metabolites is known as metabolomics.
Food Funct., 2023,14, 9050-9082
https://doi.org/10.1039/D3FO01770B
Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease
A summary of the mechanisms of various ginsenosides in the treatment of lung cancer and pulmonary inflammatory diseases.
Food Funct., 2023,14, 9137-9166
https://doi.org/10.1039/D3FO02482B
The anti-aging mechanism of ginsenosides with medicine and food homology
Ginsenosides resist the aging by regulating multiple signaling pathways.
Food Funct., 2023,14, 9123-9136
https://doi.org/10.1039/D3FO02580B
Strategies for applying probiotics in the antibiotic management of Clostridioides difficile infection
The choice of the time interval between ‘bacteria and drug’ should be based on the metabolism of antibiotics, different probiotics, probiotic antimicrobial resistance and dosage, the baseline gut ecological environment, and the host immune level.
Food Funct., 2023,14, 8711-8733
https://doi.org/10.1039/D3FO02110F
Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes
The incidences of short-term or long-term adverse maternal and fetal outcomes caused by maternal diabetes are increasing.
Food Funct., 2023,14, 8692-8710
https://doi.org/10.1039/D3FO02048G
Low-carbohydrate diet and risk of cardiovascular disease, cardiovascular and all-cause mortality: a systematic review and meta-analysis of cohort studies
LCDs were associated with 43% risk of CHD, which suggests that vigilance is necessary for long-term adherence to such dietary pattern.
Food Funct., 2023,14, 8678-8691
https://doi.org/10.1039/D3FO01374J
Current state of insect proteins: extraction technologies, bioactive peptides and allergenicity of edible insect proteins
This review presents recent findings on edible insect proteins and extraction techniques. Explores insect peptide bioactivity and bioinformatics to predict peptide features. Covers insect allergens and processing methods to mitigate allergenicity.
Food Funct., 2023,14, 8129-8156
https://doi.org/10.1039/D3FO02865H
A review of green methods used in starch–polyphenol interactions: physicochemical and digestion aspects
The interactions of starch with polyphenol under green methods.
Food Funct., 2023,14, 8071-8100
https://doi.org/10.1039/D3FO01729J
Bromelain: a review of its mechanisms, pharmacological effects and potential applications
Bromelain, an enzyme obtained from pineapple, has now been identified as having versatile pharmaceutical applications. The last decade has witnessed a paradigm shift for bromelain from food to a potential drug candidate.
Food Funct., 2023,14, 8101-8128
https://doi.org/10.1039/D3FO01060K
Evening primrose oil: a comprehensive review of its bioactives, extraction, analysis, oil quality, therapeutic merits, and safety
Evening primrose oil has attracted considerable interest worldwide because of its bioactive constituents and numerous functions in foods and health.
Food Funct., 2023,14, 8049-8070
https://doi.org/10.1039/D3FO01949G
From gut to skin: exploring the potential of natural products targeting microorganisms for atopic dermatitis treatment
Under the action of natural products, microorganisms participate in a complete cycle of the “gut-brain-skin” axis linkage mechanism, thereby regulating the development of atopic dermatitis.
Food Funct., 2023,14, 7825-7852
https://doi.org/10.1039/D3FO02455E
Revisiting carotenoids as dietary antioxidants for human health and disease prevention
Humans are unique indiscriminate carotenoid accumulators, so the role of carotenoids as dietary antioxidants with or without enzymatic conversion attracts renewed attention from the standpoint of health promotion and disease prevention.
Food Funct., 2023,14, 7799-7824
https://doi.org/10.1039/D3FO02330C
The function of human milk oligosaccharides and their substitute oligosaccharides as probiotics in gut inflammation
The human milk oligosaccharides (HMOs) can play a role as prebiotics in the treatment and prevention of gut inflammation.
Food Funct., 2023,14, 7780-7798
https://doi.org/10.1039/D3FO02092D
Dietary patterns, uric acid levels, and hyperuricemia: a systematic review and meta-analysis
A plant-based dietary pattern is associated with reduced SUA levels and a lower risk of hyperuricemia. An animal-based dietary pattern is associated with elevated SUA levels and an increased risk of hyperuricemia.
Food Funct., 2023,14, 7853-7868
https://doi.org/10.1039/D3FO02004E
Raspberry polyphenols alleviate neurodegenerative diseases: through gut microbiota and ROS signals
There are three main pathways by which polyphenols reduce ROS: direct scavenging, regulation by brain-gut axis signaling and regulation by intestinal flora.
Food Funct., 2023,14, 7760-7779
https://doi.org/10.1039/D3FO01835K
Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management
The fruit of Phyllanthus emblica Linn., which mainly grows in tropical and subtropical regions, is well-known for its medicine and food homology properties. The fruit is rich in polyphenols and has shown advantages in the field of oral health management.
Food Funct., 2023,14, 7738-7759
https://doi.org/10.1039/D3FO01671D
Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms
Microbiota dysbiosis and metabolic syndrome, consequences of a non-adequate diet, generate a feedback pathogenic state implicated in Alzheimer's disease development.
Food Funct., 2023,14, 7317-7334
https://doi.org/10.1039/D3FO01257C
Advances in the preparation and application of microencapsulation to protect food functional ingredients
Functional ingredients have multiple health benefits for humans, but are sensitive to oxidative degradation during manufacture and storage, and have poor chemical stability and reduced bioaccessibility.
Food Funct., 2023,14, 6766-6783
https://doi.org/10.1039/D3FO01077E
The structural integrity of endosperm/cotyledon cells and cell modification affect starch digestion properties
The effects of cell structure modification on starch digestibility were reviewed, and current reports were summarized according to a new classification.
Food Funct., 2023,14, 6784-6801
https://doi.org/10.1039/D3FO00856H
Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and meta-analyses
Heart failure (HF) is associated with a deficiency in blood levels of coenzyme Q10 (CoQ10), and its supplementation has been proposed.
Food Funct., 2023,14, 6302-6311
https://doi.org/10.1039/D3FO01255G
Moderate red wine intake and cardiovascular health protection: a literature review
Moderate red wine intake improves cardiovascular health by reducing oxidative stress, and playing an important role on lipid and glucose metabolism.
Food Funct., 2023,14, 6346-6362
https://doi.org/10.1039/D3FO01004J
A review of recent advances on cyanidin-3-glucoside: the biotransformation, absorption, bioactivity and applications of nano-encapsulation
C3G can be enzymatically decomposed into aglycone and further degraded into phenolic substances. Next, C3G was degraded in the distal small intestine and large intestine, and then entered the liver through blood circulation.
Food Funct., 2023,14, 6320-6345
https://doi.org/10.1039/D2FO03824B
Association of branched-chain fatty acids with metabolic syndrome: a systematic review and meta-analysis of observational studies
Branched-chain fatty acids (BCFAs) have recently emerged as a group of functional fatty acids that are widely distributed in various foodstuffs, including dairy products, ruminant meat products, and fermented foods.
Food Funct., 2023,14, 6312-6319
https://doi.org/10.1039/D3FO01320K
Maternal vitamin D deficiency and brain functions: a never-ending story
Maternal vitamin D deficiency affects brain development during foetal life and causes alterations that may persist into adulthood.
Food Funct., 2023,14, 6290-6301
https://doi.org/10.1039/D3FO00166K
Neuroprotective effects of dietary plants and phytochemicals against radiation-induced cognitive and behavioral deficits: a comprehensive review of evidence and prospects for future research
Dietary agents in mitigating radiation-induced behavioural and cognitive changes.
Food Funct., 2023,14, 5921-5935
https://doi.org/10.1039/D3FO00637A
How can plant-based protein–polysaccharide interactions affect the properties of binary hydrogels? (A review)
As the simultaneous presence of proteins and polysaccharides can significantly affect the properties of hydrogels, the current article can throw light on the differences between single-polymeric gels and the binary ones.
Food Funct., 2023,14, 5891-5909
https://doi.org/10.1039/D3FO00611E
A review of bioactive peptides as functional food ingredients: mechanisms of action and their applications in active packaging and food quality improvement
The creation of bioactive peptides (BPs) from dietary proteins holds considerable promise for the expansion of functional foods and nutraceuticals.
Food Funct., 2023,14, 5835-5857
https://doi.org/10.1039/D3FO00362K
Dietary intake patterns during pregnancy and excessive gestational weight gain: a systematic review and meta-analysis
This systematic review and meta-analysis of the association between dietary patterns and excessive gestational weight gain (EGWG) were conducted to recommend healthy dietary patterns instead of unhealthy dietary patterns for pregnant women to prevent EGWG.
Food Funct., 2023,14, 5910-5920
https://doi.org/10.1039/D3FO01550E
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases
This paper reviewed the vasculoprotective effects of hawthorn extracts and their mechanisms. Clinical trials have shown that hawthorn extracts reduce the risk factors for cardiovascular disease and the risk of poor prognosis.
Food Funct., 2023,14, 5870-5890
https://doi.org/10.1039/D3FO01688A
A comprehensive review on oat milk: from oat nutrients and phytochemicals to its processing technologies, product features, and potential applications
Plant-based milk alternatives have become increasingly desirable due to their sustainability and the increased consumer awareness of health.
Food Funct., 2023,14, 5858-5869
https://doi.org/10.1039/D3FO00893B
Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease (ND).
Food Funct., 2023,14, 5537-5550
https://doi.org/10.1039/D2FO03484K
How can chokeberry (Aronia) (poly)phenol-rich supplementation help athletes? A systematic review of human clinical trials
Athletes are increasingly consuming (poly)phenol supplements to modify oxidative stress and/or exercise-induced inflammation, in the hope that this will enhance exercise performance.
Food Funct., 2023,14, 5478-5491
https://doi.org/10.1039/D3FO00336A
Effects of food formulation on bioavailability of phytosterols: phytosterol structures, delivery carriers, and food matrices
The low solubility, high crystallinity, and instability of phytosterols restrict their bioavailability in foods. Phytosterol structures, carriers, and food matrices have important effects on the delivery, absorption, and bioactivity of phytosterols.
Food Funct., 2023,14, 5465-5477
https://doi.org/10.1039/D3FO00566F
Meta-analysis of the association between major foods with added fructose and non-alcoholic fatty liver disease
The relationship between the consumption of foods with added fructose and non-alcoholic fatty liver disease (NAFLD) was inconsistent in previous epidemiological studies, and no meta-analysis has been performed on the pooled results.
Food Funct., 2023,14, 5551-5561
https://doi.org/10.1039/D3FO00882G
Olive oil and body fat: a systematic review with meta-analysis
Diet composition has a great impact on body composition.
Food Funct., 2023,14, 5516-5536
https://doi.org/10.1039/D3FO00488K
Plant antimicrobial peptides: a comprehensive review of their classification, production, mode of action, functions, applications, and challenges
The emergence of pathogens resistant to conventional antibiotics and the growing interest in developing alternative natural antimicrobial agents have prompted a search for plant-derived antimicrobial peptides (PAMPs) in recent years.
Food Funct., 2023,14, 5492-5515
https://doi.org/10.1039/D3FO01119D
Protective effects of dietary quercetin on cerebral ischemic injury: pharmacology, pharmacokinetics and bioavailability-enhancing nanoformulations
The anti-inflammatory, anti-oxidant, anti-apoptotic and blood-brain barrier protective activities of dietary quercetin can prevent cerebral ischemia, and its nano-formulation can improve quercetin bioavailability.
Food Funct., 2023,14, 4470-4489
https://doi.org/10.1039/D2FO03122A
β-Sitosterol protects against food allergic response in BALB/c mice by regulating the intestinal barrier function and reconstructing the gut microbiota structure
β-Sitosterol, a dietary component, prevents OVA-induced food allergy by ameliorating the intestinal barrier function and reshaping the intestinal microbiota.
Food Funct., 2023,14, 4456-4469
https://doi.org/10.1039/D3FO00772C
Recent advances in the production of oligogalacturonides and their biological properties
The human population is becoming old and ageing, which is related to a variety of health issues, such as Alzheimer's disease, obesity, diabetes, hypercholesterolemia, and some types of cancers like colorectal cancer.
Food Funct., 2023,14, 4507-4521
https://doi.org/10.1039/D3FO00327B
About this collection
This themed collection features recent review articles published in Food & Function.