Themed collection Most popular 2024 organic chemistry articles

Photoswitching via indirect excitation allows harnessing low-energy photons to control molecular configuration. Herein, the state of the art of the predominant indirect photoswitching methods is presented.

Initial calculations of environmental footprints associated with using Ni vs Pd catalysis in a representative metal-catalyzed Suzuki–Miyaura cross-coupling reveal that the choice of ligated metal is often NOT of consequence. Rather, it is a culmination of other parameters such as medium.

This Perspective article highlights recent studies in which continuous flow approaches exploiting photochemical, electrochemical, and thermal reactions led to the discovery and subsequent exploitation of new reactions and reactivity patterns.

The identification of macrocyclic peptides in drug discovery demands not only advanced screening strategies but also robust and reliable synthetic methodologies to constrain peptides under biocompatible conditions.

Diaryl hypervalent bromines and chlorines emerge as a novel foundation for advancing organic chemistry. This article provides an overview of the synthetic methodology, structural variations, and the latest transformations unearthed in this context.

Green oxidation reactions performed by organocatalytic activation of hydrogen peroxide.

This perspective focuses on strategies to manipulate and optimize three key determinants of metal-based molecular photosensitizers – the absorption profile, the excited-state redox potentials, and the excited-state lifetime.

This review article highlights the diverse ways in which recent developments in the areas of photocatalysis and visible light photochemistry are impacting synthetic carbohydrate chemistry.

A structural constraint approach at a P–P bond is presented that enables the phosphinophosphination of alkynes, alkenes, and carbonyls with high regio- and diastereoselectivity. The apolar nature of the P–P bond facilitates a concerted mechanism.

The bridge X of the chelate ligand modifies doublet and quartet state energies and the excited state dynamics of luminescent chromium(III) complexes.

A multicomponent method for the synthesis of α-branched secondary alkylamines is described. The method provides expedited access to saturated N-heterocycles, and enables selective alkylation of primary amines over cyclic secondary amines.

A novel palladium-catalyzed strategy was employed to achieve higher-order (4 + 3) cycloadditions of bicyclobutanes with various 2-alkylidenetrimethylene carbonates to synthesize 2-oxabicyclo[4.1.1]octanes.

The unique optical and magnetic properties of organic biradicaloids on polycyclic aromatic hydrocarbons are of fundamental interest in the development of novel organic optoelectronic materials.

A 1,2,3,4-tetrafunctionalization of polyfluoroalkynes for the divergent construction of 5-7-membered (E)-1,2-difluorovinyl azacycles is developed.

Bicyclo[4.1.1]octanes (BCOs) were synthesized in up to quantitative yields through the formal [4+2] cycloaddition of aryl and alkyl bicyclobutane (BCB) ketones with dienol silyl ethers using Al(OTf)₃ as a Lewis acid catalyst.

Diverse amines and amino acids are now readily accessed from carboxylic acids, aldehydes, and amine precursors in a direct decarboxylative reaction enabled by a homogeneous triple catalytic system based on acridine photocatalysis.

Five molecules at the energy-chemistry nexus, their position in the planetary boundary framework and Anthropocene-spurred interdisciplinary connections between chemistry, social sciences, and humanities to help define sustainability-driven research.

The aromatization-driven deconstructive coupling of spiro carbocycles with organic halides via dual photoredox/nickel catalysis is developed. An in-depth mechanism study revealed that this reaction proceeded via a radical-metal crossover pathway.

The photo-induced azole C–H arylation was realized with a dual-catalytic copper-based system. Exceedingly mild reaction conditions at ambient temperature and visible light irradiation enabled a broad scope with high functional group tolerance.

Radical-mediated direct photoredox β-C(sp³)–H arylation of 1-(o-iodoaryl)alkan-1-ones with cyanoarenes directed by an iodoarene group is depicted.

Low-cost formate salt was used as the reductant and part of the carboxyl source in a visible-light-driven dicarboxylation of diverse alkenes, including simple styrenes.

A new integrated approach to BN-polycycles is rooted in a clean condensation of amines with B(allyl)₃. The end game includes a gram-scale synthesis of BN-naphthalene through efficient aromatization, or assembly of BN-polycycles via enyne metathesis.

The information (a proverb from The Analects of Confucius) is stored in chain-end degradable sequence-defined oligourethanes, sequenced with liquid chromatography-mass spectrometry (LC-MS) under suitable conditions and decrypted with in-house Python scripts.

We present NHC-catalyzed atroposelective esterification of prochiral dialdehydes, delivering enantioenriched axially chiral diaryl ethers. Matched kinetic resolutions amplify the enantioselectivity by removing minor enantiomers via over-functionalization.

In this study, a mechanochemical protocol for highly efficient and ammonia-free sodium-based Birch reduction was developed, leveraging the use of cheap and easy-to-handle sodium lumps and D-(+)-glucose as a proton source.

The Accelerated SuFEx Click Chemistry (ASCC) protocol, adapted to a 96-well plate format, has been applied to the late-stage derivatization of bioactive molecules and array synthesis of anticancer agents, showcasing its potential for drug discovery.

A reductive and denitrative amination of nitroarenes has been developed, allowing the highly selective synthesis of various di- and triarylamines. The protocol employed synthetically upstream nitroarenes as both the electrophiles and amine sources.

Two complementary strain-enabled radical spirocyclization cascades have been realized to synthesize spirocyclobutyl lactones and – lactams. The reactions operate under mild conditions and demonstrate excellent functional group compatibility.

Advances in site-selective molecular editing have enabled structural modification on complex molecules.

Herein we report a branch-selective allylation strategy for accessing C2-indolyl-all-carbon quaternary centers using allylboronic acids and implemented this method for the total synthesis of the mersicarpine alkaloid.

Simple iron salts are able to photocatalyze the diazidation, dichlorination, and fluorochlorination of alkenes via the merger of ligand-to-metal charge transfer (LMCT) and either radical ligand transfer (RLT) or fluorine atom transfer (FAT).