Editorial
Frontiers in stimuli-responsive nanoplatforms: pioneering drug delivery in nanobiotechnology
Prof. Juan C. Cruz and Prof. Luis H. Reyes introduce the Nanoscale Advances themed issue on Frontiers in Stimuli-Responsive Nanoplatforms: Pioneering Drug Delivery in Nanobiotechnology.
Review Article
Strategies for enhanced gene delivery to the central nervous system
Biological barriers in the central nervous system.
Communication
Dual-color core–shell silica nanosystems for advanced super-resolution biomedical imaging
Tailored synthesis and biotin-functionalization of dual-colored SiO2 nanoparticles as tools for advanced super-resolution microscopy imagining in biomedical approaches.
Paper
Preparation of a minocycline polymer micelle thermosensitive gel and its application in spinal cord injury
Neuroprotection is an important approach for the treatment of spinal cord injury (SCI).
Paper
Effects of silver-decorated PLGA nanoparticles on Staphylococcus epidermidis biofilms and evaluation of the detoxification limit of bacteria against these nanoparticles
Silver nanoparticles exhibit high antibacterial activity and thus have been used in polymeric formulations for drug delivery.
Paper
Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles
Investigating complex patterns in the plasma protein corona of different liposomal formulations to identify formulation-specific protein clusters which in turn may suggest possible targeting capability.
Paper
Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants
Thermo- and pH-responsive polymers' dissolution in vivo can be broadly fine-tuned. Polymeric implant can be detected in vivo using “hot-spot” 19F MR measurement. Long-term in vivo dissolution of polymeric implant shows no side effects.
Paper
In vitro profiling and molecular dynamics simulation studies of berberine loaded MCM-41 mesoporous silica nanoparticles to prevent neuronal apoptosis
Berberine-loaded mesoporous silica nanoparticle-controlled drug release by a simple or quasi-diffusion mechanism, improving neuronal health, preventing apoptosis, and restoring mitochondrial membrane potential.
Paper
Probing the pH-dependency of DC-SIGN/R multivalent lectin–glycan interactions using polyvalent glycan-gold nanoparticles
DC-SIGN displays distinct pH-dependent binding with GNP-DiMan, strong tetravalent binding to single GNP-DiMan at pH 7.4, weak crosslinking at pH 5.4, and no apparent binding at pH 4.6, consistent with its biological role as an endocytic recycling receptor.
Paper
Bioelectrochemically triggered apoferritin-based bionanoreactors: synthesis of CdSe nanoparticles and monitoring with leaky waveguides
Enzymatic processes, specifically laccase (Lac) catalysis, control molecular or nanomaterial synthesis within apoferritin by inducing a local pH change. Leaky waveguides technique is used for real-time monitoring of CdSe nanoparticles synthesis.
Paper
A new vision of photothermal therapy assisted with gold nanorods for the treatment of mammary cancers in adult female rats
Graphical abstract showing the whole photothermal process assisted with gold nanoparticles in female rats.
Paper
Surfactant-driven optimization of iron-based nanoparticle synthesis: a study on magnetic hyperthermia and endothelial cell uptake
This work examines the effect of changing the ratio of different surfactants in single-core iron-based nanoparticles in the context of magnetic hyperthermia and cellular uptake by human umbilical vein endothelial cells.
Paper
Synthesis of a light-responsive platinum curcumin complex, chemical and biological investigations and delivery to tumor cells by means of polymeric nanoparticles
The combination of chemical synthesis and nanotechnology led to the creation of a powerful multifunctional drug delivery system for a new platinum curcumin complex.
Paper
Light-initiated aggregation of gold nanoparticles for synergistic chemo-photothermal tumor therapy
The combination of chemotherapy with photothermal therapy (PTT) has attracted extensive attention due to its excellent synergetic effect attributing to the fact that hyperthermia can effectively promote the tumor uptake of chemotherapeutic drugs.
About this collection
Guest Edited by Prof. Juan C. Cruz and Prof. Luis H. Reyes (Universidad de los Andes, Colombia). This collection focuses on the recent developments and novel approaches in stimuli-responsive nanoplatforms for drug delivery. Papers highlight the design, synthesis, and application of these nanoplatforms, with an emphasis on their potential to transform therapeutic delivery methods. We aim to highlight the intersection of nanobiotechnology and drug delivery, fostering discussions on future trends and challenges within this exciting field.