Themed collection Editors' Collection: Greener synthetic approaches towards quinoline derivatives

Herein, we demonstrate a simple, rapid and green synthesis of 2,4-dimethoxy-THPQs under microwave irradiation and their antiproliferative activity, in silico ADMET and drug-likeness studies were carried out.

An efficient and elegant assembly of pyrene/aryl fused pyrrolo[2,3-b]quinolinone and pyrrolizino[3,2-b]quinolinone hybrid heterocycles was achieved via a domino multicomponent reaction strategy using a solid state melt reaction (SSMR) condition.

Herein, we report the synthesis of hercynite@sulfuric acid as a novel nanomagnetic solid acid catalyst, containing the sulfuric acid catalytic sites on the surface of hercynite MNPs as the catalytic support.

A simple synthesis of indeno-[1,2-b]-quinoline-9,11-(6H,10H)-dione derivatives and 7,7-dimethyl-10-aryl-7,8-dihydro-5H-indeno[1,2-b]quinoline-9,11(6H,10H)-diones using aromatic aldehydes with heterogeneous CuO on a zeolite-Y catalyst is reported.

A green, straightforward and efficient study for obtaining hybrid quinoline-imidazole derivatives under ultrasound (US) irradiation as well as under conventional thermal heating (TH) has been presented.

Sustainable fabrication of spherical N-GQDs/CoFe₂O₄ nanocomposites as a novel magnetically retrievable catalyst for the synthesis of quinoline-3-carbonitrile derivatives has been developed.

A solid catalyst, cesium salt of 2-molybdo-10-tungstophosphoric acid (Cs_2.3H_0.7PW₁₀Mo₂O₄₀) named as Cs-3, was synthesized by a simple, cheap, clean, and eco-friendly method.

A series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived “green” solvent γ-valerolactone and evaluated for their inhibitory activities against PTP1B, compound 6a displayed an IC₅₀ value of 8.04 ± 0.71 μM with 4.34-fold preference over TCPTP.

A novel core@double-shell acidic nanocatalyst (Fe₃O₄@SiO₂@RF–SO₃H) was prepared, characterized and applied in catalytic one-pot condensation between aromatic aldehydes, dimedone, malononitrile, and ammonium acetate for synthesis of hexahydroquinoline derivatives.

Preparation of core–shell magnetic mesoporous N-doped silica nanoparticles as a new solid base catalyst was studied. obtained catalyst was used for the preparation of some arylpyrimido[4,5-b]quinoline diones under green conditions.

Substrate selectivity in the novel multi-component reaction of 5-aminoindazole, barbituric acid derivatives and aldehyde is explored.

SQs displaying anti-Alzheimer activity is serendipitous. Malononitrile as a handle to facilitate nucleophilic attack has been applied for the first time for the easy access of SQs.

An iodine-catalyzed aerobic dehydro-aromatization has been developed, providing a straightforward and efficient access to various benzoazoles and benzoazines.

Herein, we report a simple and metal-free protocol for the synthesis of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinolines.

A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium.

KO^tBu-promoted oxidative dimerizations of 2-methylquinolines with molecular oxygen as the oxidant have been developed for the first time.

C–H amination at the C5 position of 8-aminoquinolines with azodicarboxylates proceeded efficiently using a nickel/silver co-catalyst at room temperature without any additional ligand, base or oxidant.

An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5-a]quinolines with moderate to good yields.

Triple zirconocene/brønsted acid/CuO cooperative and relay catalysis system for tandem Mannich addition/C–C formative cyclization/oxidation.

Highly efficient and regioselective Friedlander synthesis of 2-methyl-3-acyl quinolines and their chemoselective C_sp³–H functionalization is described for the first time using Ca(OTf)₂ as the sustainable catalyst under solvent free conditions with atom and step economy.

Quinoline was synthesized via the typical Skraup approach with a vapor-phase process. The mesoporous Ni/beta zeolite catalyst exhibited high-efficiency catalytic activity and an enhanced ability of anti-deactivation.