Themed collection Targeted biomedical applications of nanomaterials

Dhiraj Bhatia, Mukesh Dhanka, Anjali Awasthi, Kamlendra Awasthi and Kaushik Chatterjee introduce the Journal of Materials Chemistry B, Nanoscale, Materials Advances and Nanoscale Advances themed collection on targeted biomedical applications of nanomaterials.

This article presents MXenes' potential in 3D bioprinting, discussing their benefits for bio-printed scaffolds, 3D bioprinting techniques, bio-ink criteria, applications of MXene-incorporated constructs, current challenges, and future directions.

DNA's extraordinary potential reaches far beyond its role as a carrier of genetic information.

CB-NMs, have revolutionized the agricultural sector in various ways including the on-demand supply of essential nutrients, biomolecules, and growth factors to plants.

Enhancing cell-material interactions through surface engineering to create biomimetic environments and extend implant life.

A comprehensive overview of bioactive glass–polymer nanocomposites highlighting the various fabrication strategies, the materials involved and the major biomedical applications.

After the discovery of DNA during the mid-20^th century, a multitude of novel methodologies have surfaced which exploit DNA for its various properties.

Nanocarrier-based targeting tumor-associated macrophages can reprogram pro-tumor M2 macrophages into anti-tumor M1 macrophages, offering a promising approach for advanced breast cancer treatment. Image created in BioRender.com.

This review critically examines the recent advances in the innovative use of biopolymeric and lipid-based nanomaterials in developing safer and more effective mosquito-repellent formulations to prevent mosquito-transmitted diseases.

Aging leads to diseases marked by plaque formation, increased senescent cells, and compromised body organ systems. Light-responsive nanomaterials offer a promising therapeutic approach to address the various aspects of age-related pathologies.

An overview of biosensors for airborne pathogenic fungal spore detection.

Advancements in RA therapy from conventional drugs to nanomedicines based on immune cell therapy, which increases the specificity of the treatment and decreases the off-site effects, are reported. Images are created with BioRender.com.

With the advent of DNA nanotechnology, DNA-based biomaterials have emerged as a unique class of materials at the center of various biological advances.

DNA nanostructures have surfaced as intriguing entities with vast potential in biomedicine, notably in the drug delivery area.

Conventional biomaterials suffer from mechanical stresses and biochemical degradation, compromising performance and structural integrity.

A quercetin nanocrystal containing alginate hydrogel patch demonstrates rapid wound healing of skin wounds in rat and mouse models.

ConA-conjugated curcumin-loaded solid lipid nanoparticles, their characterization (UV-vis, DSC, PSA, ATR-FTIR, XRD, SEM), and therapeutic applications in lung cancer, including drug release, anti-proliferation assays, and lung model studies.

We investigate the interactions of glycogen nanoparticles (emerging biomaterials for theranostic applications) from different sources with human blood, finding that all are hemocompatible nanomaterials. Image via Blender Foundation (www.blender.org).

Synthesis and fabrication of redox-switchable polymeric lipid hybrid nanocarriers that selectively deliver berberine and induce apoptosis in GSH-rich cancer cells while sparing healthy cells.

A nano-ceria integrated microfluidic electrochemical immunosensor for IL8 biomarker detection in human saliva samples.

An immunoliposome-based targeted delivery of paclitaxel and miR155 inhibitor to HER2-positive breast cancer cells. Preclinical studies reveal reduced tumor volume, apoptosis induction, and minimal toxicity, highlighting its therapeutic potential.

Electrochemical oxidation of creatinine via TiO₂ nanotube flow-through membranes (TNTsM).

Liver-based hydrogel transplanted hepatocyte and cholangiocyte organoids as an efficient cell source and therapy for renewal of hepatocytes, angiogenesis, restoration of hepatocyte functions and resolution of liver injury.

The schematic diagram of a 3D-printed biomimetic scaffold applied to tendon–bone interface repair.

Synthesis of an L-cys_rGO hydrogel and fabrication of a BSA/anti-TNF-α/L-cys_rGO hydrogel/gSPE immunosensor.

Liver cancer, with 800 000 new cases annually, is driven by Wnt/β-catenin pathway mutations in over 80% of cases. This study aims to develop a novel strategy to target this pathway, inhibit cancer cell growth and downregulate oncogenic gene expression.

Highly branched poly(N-isopropyl acrylamide) additives chain end functionalised with vancomycin have been designed to agglutinate and report on targetted Gram-positive strains of bacteria (S. aureus).

The integration capitalizes on the free radical scavenging abilities of cerium-based materials, boosting the system's antioxidant capacity. This novel drug delivery preserves the tumor suppressive impact of the anticancer drugs.

Brief method for hydrogel preparation.

Peptide functionalized-reduced graphene oxide biomaterial for wound care applications.

The selective assembly of ubiquicidin antimicrobial peptide near a lipid monolayer was explored in this article aiming to understand the role of available lipids in a bacterial membrane.

Schematic illustration of design, administration, and mechanism of action of Pira/Sal dual-loaded FA-conjugated redox responsive [S-(PLA-b-PEG-CONH)]₂ block copolymeric nanoparticles.

Sustained delivery of NDGA via polymeric microparticles maintains therapeutic levels in joints, reduces cartilage damage, and alleviates post-traumatic osteoarthritis (PTOA) in mice through ROS modulation and autophagy induction.

L-Cysteine capped MoS₂ QDs are synthesized and employed for dual-channel imaging and superior Fe³⁺ ion sensing in biological systems.

This study investigated the development and evaluation of rebamipide nanocrystals (REB-NCs) a BCS class IV drug for enhancing solubility and permeability, and used as anti-ulcer medication.

Schematic illustrating calcium peroxide (CaO₂) nanoparticles capable of supplying H₂O₂/NO upon NIR trigger, synergising with a ferroptosis inducer, RSL-3 (CPIR NPs) for photothermal ferroptosis through mitochondrial damage and lipid peroxidation.

Diabetes mellitus (DM) is a chronic metabolic condition, characterized by hyperglycaemia, oxidative imbalance, pancreatic β-cell death, and insulin insufficiency.

Membrane active peptides (MAPs) can provide novel means to trigger the release of liposome encapsulated drugs to improve the efficacy of liposomal drug delivery systems.

Ag–TiO₂ coating on various medical-grade biomaterials demonstrates their antibacterial and antibiofilm properties.

Carbon quantum dots derived from mango leaves exhibited red fluorescence.

A rGO/ZnO nanocomposite membrane had excellent filtration properties with good antifouling behaviour.

Hemin-loaded hyaluronan needle-like microparticles can protect against the UV-induced damage of dermal fibroblasts and the accompanied oxidative and nitrosative stress.

X-ray fluorescence imaging tracks liposomes with high resolution and penetration depth. The encapsulated ruthenium(II) polypyridyl dye enables dual mode imaging.

Polyunsaturated fatty acids (PUFAs) loaded onto the porous acrylate-based scaffolds significantly enhance the expression of osteogenic markers.

Antibiotic resistance continues to pose significant health challenges. Dual action soft nanoparticles provide an advantageous platform to address it.

Targeted and efficient gene delivery systems hold tremendous potential for the improvement of cancer therapy by enabling appropriate modification of biological processes and the strategic design of the delivery vector plays a critical role in the improved efficacy.

Self-assembly phenomena at the liquid–liquid interface measured using inverted pendant drop tensiometry, provide insights into the jamming of nanocolloids governed through structural organization at the nanoscale due to their shape anisotropy.

A supramolecular strategy for the fabrication of a PDT-active 2D nanosheet loaded with a POD-mimicking DNAzyme for the synergetic combination of PDT and CDT for targeted cancer therapy is reported.

This work reports the fabrication of nanocomposite antimicrobial films loaded with quorum sensing inhibiting compounds exhibiting maximum ~7log₁₀ reduction in bacterial cell viability highlighting the role of preparation strategy in microbial coatings.

Biodegradable porous nanomaterials have emerged as a promising avenue for tumor drug delivery owing to their capacity to encapsulate large quantities of drugs and their compatibility with biological systems.

DNA cages loaded with Dopamine as carriers for dopamine release in neuronal cells for applications in neurological disorders.

Epoxy-based 3D microelectrode arrays facilitate extracellular recordings in non-planar environments.

Nitrogen-based quantum dots (N-Ch-CQDs) serve as an efficient biosensor platform with bioimaging capabilities to combat antibiotic resistance resulting from norfloxacin residues, which pose a significant public health threat due to their incomplete metabolism and non-biodegradable nature.

PPy flower/Ni foam-based electrode has been used for the selective detection of p-NP which showed linear detection of 0.01–20 nM, LOD of 7.18 pM and high sensitivity of 5.37 μA nM⁻¹ cm⁻².

Over the past several years, a significant increase in the expanding field of biomaterial sciences has been observed due to the development of biocompatible materials based on peptide derivatives that have intrinsic therapeutic potential.

Titanium-based orthopedic implants are gaining popularity in recent years due to their excellent biocompatibility, superior corrosion resistance and lightweight properties.