Themed collection Nanoscale 2025 Emerging Investigators


Characterisation of polymeric nanoparticles for drug delivery
Polymeric nanoparticles represent an innovative approach to drug delivery, particularly for addressing complex diseases like cancer.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00071H
External strategies for enhanced sensing performance of self-powered polyvinylidene fluoride-based sensors
External strategies such as electrode design, stress/heat transfer improvements, microstructure optimization, and multifunctional synergy show great potential for improving sensing performance of PVDF-based sensors. Images reproduced with permission, full details in paper.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05200E

Sustainable nanofibrous membranes for air filtration, water purification and oil removal
The increasing demand for sustainable solutions to address environmental and energy challenges has driven the development of advanced materials. This paper highlights recent advancements in the development of sustainable nanofibrous membranes.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04673K
Leveraging the dual role of ROS in liver diseases with nanomaterials: clearing and amplifying for therapy
The dual role of ROS in liver diseases, and the potential of nanomaterials with catalytic activity for therapeutic applications are examined.
Nanoscale, 2025,17, 3688-3697
https://doi.org/10.1039/D4NR04469J
NIR-II upconversion nanomaterials for biomedical applications
This review provides a comprehensive overview of recent biomedical applications of upconversion nanomaterials specifically within the near-infrared two-region (NIR-II) window (1000–1700 nm).
Nanoscale, 2025,17, 2985-3002
https://doi.org/10.1039/D4NR04445B

Advances in integrated power supplies for self-powered bioelectronic devices
The emerging integrated power supplies for self-powered bioelectronic devices over the past few years are summarized. Additionally, the challenges and future perspectives in self-powered device design and manufacturing are also indicated.
Nanoscale, 2025,17, 2423-2437
https://doi.org/10.1039/D4NR04645E

Design strategies and performance enhancements of PVDF-based flexible electrolytes for high-performance all-solid-state lithium metal batteries
Lithium metal is considered one of the most promising anode materials for lithium batteries due to its high theoretical specific capacity (3860 mA h g−1) and low redox potential (−3.04 V).
Nanoscale, 2025,17, 2408-2422
https://doi.org/10.1039/D4NR04583A
Organic semiconductor bulk heterojunctions for solar-to-chemical conversion: recent advances and challenges
This minireview highlights recent progress in BHJ-based photoelectrochemical cells and photocatalysts for solar-to-chemical conversions.
Nanoscale, 2025,17, 1889-1921
https://doi.org/10.1039/D4NR03938F
Advanced applications in enzyme-induced electrospun nanofibers
Guidelines for tailored enzyme-induced electrospun nanofiber immobilization techniques: aligning fabrication methods with future application requirements.
Nanoscale, 2024,16, 19606-19619
https://doi.org/10.1039/D4NR03404J

Recent advances in the fundamentals and in situ characterizations for mechanics in 2D materials
This review involves advances in the mechanics of 2D materials, including measurement methods, sample transfer, materials design, and mechanisms covering the impact of defects and thickness for highly-bendable 2D materials.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05171H
Recent progress on transition metal dichalcogenide-based composites for cancer therapy
In this review, we present the recent progress on transition metal dichalcogenide-based composites, including their typical categories, key fabrication strategies, and transformative roles in the field of cancer therapy.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05510A
Modulation anisotropy of nanomaterials toward monolithic integrated polarization-sensitive photodetectors
This review provides an overview of linear, circular, and full-Stokes photodetectors, discussing how to simplify their design from complex to simple. Images by permission of: RSC 2021, WLY 2023, Optica Publishing Group 2016 and ACS 2020.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05034G
Nanoscale high-entropy alloys for solar and thermal applications
This review highlights the advantages of non-annealing synthesis, emphasizing the importance of in situ characterization, multi-level simulations and machine learning to accelerate photo-/thermocatalytic research in nanoscale high-entropy alloys.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04697H
Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery
This review systematically describes the preparation of poly(amino acids) and peptides, and their use in drug loading for various diseases, offering insights for research and clinical applications of degradable biomedical polymers.
Nanoscale, 2025,17, 3549-3584
https://doi.org/10.1039/D4NR04481A

Flexible, Wearable Mechano-Acoustic Sensors for Body Sound Monitoring Applications
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05145A
Strategic design of emerging (K,Na)NbO3-based perovskites for high-performance piezocatalysis and photo-piezocatalysis
This comprehensive review of (K,Na)NbO3-based perovskites explores design strategies, mechanisms, and applications in piezocatalysis and photo-piezocatalysis for sustainable environmental and energy solutions.
Nanoscale, 2025,17, 2931-2960
https://doi.org/10.1039/D4NR04415K
Patterning technologies of quantum dots for color-conversion micro-LED display applications
A comprehensive summary of patterning technologies of quantum dots for construction of color-conversion layers in full-color micro-LED displays is provided.
Nanoscale, 2025,17, 1764-1789
https://doi.org/10.1039/D4NR03925D
Single atoms meeting 2D materials: an excellent configuration for photocatalysis
The state-of-art progress in single-atom tuned two-dimensional materials is reviewed to clarify the distinctive advantages in photocatalysis and present the crucial structure–activity relationship for improved performance.
Nanoscale, 2024,16, 22077-22098
https://doi.org/10.1039/D4NR03787A
Recent advances in flexible multifunctional electrochromic devices
This review comprehensively summarizes the recent development of flexible multifunctional electrochromic devices, including energy harvesting, energy storage, multicolor displays, and smart windows.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04074K
Rational nanoparticle design for efficient biomolecule delivery in plant genetic engineering
Nanoparticle-mediated approaches to plant genetic engineering represent key advances in agriculture, offering benefits beyond conventional techniques. This review discusses essential nanoparticle design considerations to optimize delivery efficiency.
Nanoscale, 2024,16, 21264-21278
https://doi.org/10.1039/D4NR03760J
Recent advances in tungsten oxide-based chromogenic materials: photochromism, electrochromism, and gasochromism
Applications of WOx in photochromic, electrochromic, and gasochromic materials and devices.
Nanoscale, 2024,16, 21279-21293
https://doi.org/10.1039/D4NR03781B
New paradigms of 2D layered material self-driven photodetectors
The burgeoning initiatives implementing self-driven 2D layered material photodetectors have been presented, heralding new avenues for the next-generation integrated and miniaturized optoelectronic industry.
Nanoscale, 2024,16, 20811-20841
https://doi.org/10.1039/D4NR03543G
Developments, challenges and future trends in advanced sustainable machining technologies for preparing array micro-holes
The use of array micro-holes is becoming increasingly prevalent across a range of industries, including the aerospace, automotive, electronics, medical and chemical industries.
Nanoscale, 2024,16, 19938-19969
https://doi.org/10.1039/D4NR02910K
FRET-Driven Hybrid Polymer–Perovskite Matrices for Efficient Pure-Red Emission
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05253F

SnSb as a long cycle life anode material for sodium-ion batteries enabled by a high concentration electrolyte
The performance of a SnSb Na-ion battery anode composed of nanolayers of Sn and Sb is reported, wherein the cycle life was significantly enhanced by the use of a high concentration electrolyte.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03820G

Slippery liquid-like surfaces as a promising solution for sustainable drag reduction
Fluid slip and drag reduction induced by durable slippery liquid-like surfaces (SLLSs) made from flexible polymers.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04507F
Nanoparticle-assembled interconnected PbO1.44 hollow spheres enabled by PVP-driven transformation of β-PbO2 and self-sacrificial templating for superior lithium storage
Nanoparticle-assembled interconnected PbO1.44 hollow spheres (NAHSs) were crafted by a robust strategy of PVP-driven transformation of β-PbO2 microspheres (MSs) combined with a self-sacrificial templating mechanism for superior lithium storage.
Nanoscale, 2025,17, 3023-3034
https://doi.org/10.1039/D4NR04763J

Exfoliation of triazole-based C3N4.8, C3N6, and C3N7 nanosheets for efficient photocatalytic ammonia production
Triazole-based C3N7 nanosheets exhibit excellent photocatalytic ammonia production performance, attributed to their inherent properties of an optimised conduction band position and efficient charge separation.
Nanoscale, 2025,17, 2438-2443
https://doi.org/10.1039/D4NR03639E
Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes
CLASSIC is a label-free DNA detection platform with single-nucleotide specificity and attomolar sensitivity. This assay offers rapid and sequence-specific DNA analysis through single-strand conversion and split light-up aptamer probes.
Nanoscale, 2024,16, 20067-20072
https://doi.org/10.1039/D4NR01638F
Protecting Li-metal anode with LiF-enriched solid electrolyte interphase derived from a fluorinated graphene additive
An LiF-enriched (composition-wise) and organic/inorganic uniform-distributed (structure-wise) SEI film architecture was derived by fluorinated graphene (F-Gr) sacrificial additive to promote efficient Li-metal protection.
Nanoscale, 2024,16, 19633-19641
https://doi.org/10.1039/D4NR02877E
Simultaneous formation of helical and sheet-like assemblies from short azapeptides enables spontaneous resolution
Bioinspired 1D helical and 2D sheet-like assemblies are combined to form a 3D homochiral assembly that allows spontaneous resolution.
Nanoscale, 2024,16, 19221-19227
https://doi.org/10.1039/D4NR02872D

Harnessing DFT and machine learning for accurate optical gap prediction in conjugated polymers
Bridging the gap between DFT-calculated and experimental optical gap of conjugated polymers using machine learning, side-chain features, and a modified oligomer model.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03702B
Effect of channel patterning precision on the performances of vertical OECTs
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05239K
Rational synthesis of carbon-rich hollow carbon nitride spheres for photocatalytic H2O2 production and Cr(VI) reduction
Hollow carbon nitride spheres with a well-designed architecture and excellent optical properties serve as promising polymers for high-value chemical production and heavy metal treatment.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05501B
Copper nanoclusters with aggregation-induced emission: an effective photodynamic antibacterial agent for treating bacteria-infected wounds
Highly luminescent Cu NCs with AIE as photodynamic antimicrobial agents were synthesized and they exhibited exceptional photodynamic bacterial inactivation in vitro, alongside effective treatment of bacteria-infected wounds in vivo.
Nanoscale, 2025,17, 5778-5787
https://doi.org/10.1039/D4NR04718D
Changing the amyloid nucleation process using small molecules and substrates: a way to build two-dimensional materials
The assembly of two-dimensional (2D) peptide materials on substrates with the control of FG small molecules
Nanoscale, 2025,17, 5788-5797
https://doi.org/10.1039/D4NR04624B

Preparation of bovine serum albumin nanospheres via desolvation: a study of synthesis, characterization, and aging
Bovine serum albumin nanoparticles synthesized via a modified desolvation method exhibit superior long-term stability in aqueous dispersion. Glucose investigated as a “green” alternative crosslinker.
Nanoscale, 2025,17, 5715-5731
https://doi.org/10.1039/D4NR04682J
Mitochondria-targeting nanostructures from enzymatically degradable fluorescent amphiphilic polyesters
pH-responsive aqueous nanoassembly from a fluorescent neutral polyester selectively targets mitochondria in cancer cells over non-cancerous cells due to positive charge gain, while similar assemblies from cationic polyesters show no such selectivity.
Nanoscale, 2025,17, 5732-5742
https://doi.org/10.1039/D4NR04696J

Revealing nanoscale slip within Taylor–Aris dispersion
Hydrodynamic slip at fluid–solid interfaces plays an important role in a range of transport phenomena, including Taylor–Aris dispersion.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03468F
Nanoparticles alter locust development and behaviour
The image illustrates the effect of nanoparticle-treated lettuce on locusts, showing their initial avoidance, eventual feeding, and subsequent death, suggesting a potential pest control strategy.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04993D
Fluffy mesoporous Al2O3 supported Ag–In2O3 schottky junction catalysts for selective hydrogenation of C
O of α,β-unsaturated aldehydes
Highly selective hydrogenation of CO of α,β-unsaturated aldehydes to unsaturated alcohols was achieved over a fluffy mesoporous Al2O3-supported Ag–In2O3 Schottky junction catalyst.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05518G

Ultra-High Absorption Efficiency of InN Nanowires with A Wide Bandwidth in The Short-wave Infrared Range
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR04586F

Self-healing and Highly Adhesive Conductive Polydimethylsiloxane-Based Elastomers for Chronic Epilepsy Monitoring
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR00171D
Demonstration of 300 mm RF-SOI wafers fabricated by layer transfer technology
The key fabrication technologies for domestic 300 mm wafer-level RF-SOI are demonstrated for the first time. The 300 mm RF-SOI wafers with less than 3 Å Top-Si roughness and −95 dB m 2nd harmonic distortion at 900 MHz were successfully fabricated.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04439H
Encapsulated ruthenium sites in reaction microenvironment-regulated UiO-66 for stable acetylene hydrochlorination
We employed an encapsulation strategy and channel regulation for Ru sites to enhance the stability and activity in acetylene hydrochlorination.
Nanoscale, 2025,17, 5181-5190
https://doi.org/10.1039/D4NR04506H

Doping Gd16 nanoclusters for expanded optical properties and thermometry applications
We achieved green–red color-tunable luminescence by controlling the doping of Tb3+ and Eu3+ ions in Gd16 clusters and attained a high relative sensitivity of up to 4.6% K−1 in the as-doped Gd15Tb1−xEux (x = 0.8).
Nanoscale, 2025,17, 5074-5080
https://doi.org/10.1039/D4NR04779F

A high sensitivity prostate-specific antigen SERS detection platform based on laser resonance nanoparticles
An immunoassay based on SERS was established using antibody magnetic beads and SERS nanotags. This method has the advantages of simple operation, high sensitivity, fast (10 minutes) detection, low cost and portability.
Nanoscale, 2025,17, 5171-5180
https://doi.org/10.1039/D4NR04510F

Facet-controlled electrosynthesis of nanoparticles by combinatorial screening in scanning electrochemical cell microscopy
SECCM allows screening of facet-controlled electrodeposition of nanoparticles.
Nanoscale, 2025,17, 5141-5149
https://doi.org/10.1039/D4NR04564E
Defect passivation engineering of chalcogenide quantum dots via in situ fluorination treatment
Efficient carrier transport through reducing the traps in chalcogenide quantum dots (QDs) is crucial for their application in optoelectronic devices.
Nanoscale, 2025,17, 5064-5073
https://doi.org/10.1039/D4NR04410J
Unveiling the inhibition mechanism of host-defense peptide cathelicidin LL-37 on the amyloid aggregation of the human islet amyloid polypeptide
The host-defense peptide cathelicidin LL37 inhibits the amyloid aggregation of human islet amyloid polypeptides by hydrophobic associations and pi–pi interactions.
Nanoscale, 2025,17, 5116-5127
https://doi.org/10.1039/D4NR05075D
Boosting Cu ion capture in high-salinity environments with amino-functionalized millispheres
This study demonstrates the development of amino-functionalized chloromethylated polystyrene (EDA@CMPS) millispheres that exhibit enhanced Cu ion adsorption in saline environments through salt-promoted protonation of amino groups.
Nanoscale, 2025,17, 5106-5115
https://doi.org/10.1039/D4NR04517C
Built-in electric field in the Mn/C60 heterojunction promotes electrocatalytic nitrogen reduction to ammonia
The built-in electric field in the Mn/C60 heterostructure optimized the adsorption energy of the key intermediate *NH–*NH2 and reduced the free energy barrier for the third hydrogenation step, which enhanced the intrinsic activity of the NRR.
Nanoscale, 2025,17, 5090-5097
https://doi.org/10.1039/D4NR04496G
Magnetically targeted delivery of probiotics for controlled residence and accumulation in intestine
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR04753B
Ionizable Lipid Nanoparticles Enhance Lung-Delivery of Gold Nanocluster for Improving Acute Lung Injury Alleviation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05415F

Supramolecular electrostatic functionalization of 1T-MoS2 based on alkylammonium salts
The electrostatic functionalization between negative-charged 1T-MoS2 and positive-charged alkylammonium salts allows high functionalization yields while preserving the material's favorable properties.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05515B
Quantitative comparison of local field enhancement from tip-apex and plasmonic nanofocusing excitation via plasmon-assisted field emission resonances
A novel method for comparing near-field intensities of the localized surface plasmon excited by different schemes in a scanning-tunneling-microscope junction.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04262J

Studying the effect of dimensions and spacer ligands on the optical properties of 2D lead iodide perovskites
This study explores 2D lead iodide perovskites with varying spacer chains, comparing bulk poly-crystals, colloidal nanoplatelets, and thin films. Their optical properties mainly depend on structural distortion and the bulk-to-surface ratio.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05516K

Spectral and dynamical properties of multiexcitons in semiconductor nanorods
Applying an MCMC sampling approach for global target analysis enables us to determine the contributions of multiple exciton decay via Auger recombination and the contribution of surface exciton states to the observed decay dynamics.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04692G
Multilevel, solar-blind, and thermostable physical unclonable functions based on host-sensitized luminescence of β-Ga2O3:Dy3+
The luminescent properties of β-Ga2O3:Dy3+ enable the development of optical PUF tags with exceptional encoding capacity, solar-blind response, and thermal stability, making them highly effective for anti-counterfeiting and encryption applications.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05237D
Kinetic analysis of silver nanowire synthesis: polyol batch and continuous millifluidic methods
Nucleation (k1) and growth (k2) rate constants for the polyol silver nanowire synthesis were determined for batch and millifluidic flow reactors (MFRs). The MFR rate constants are larger in magnitude and synthesize AgNWs faster than batch reactors.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03812F
Controllable magnetism and an anomalous Hall effect in (Bi1−xSbx)2Te3-intercalated MnBi2Te4 multilayers
In (Bi1−xSbx)2Te3 intercalated MnBi2Te4 multilayers, structural engineering is employed to modulate both the anomalous Hall response and magnetism.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05486E
Morphology-tuned MnOx/TiO2 nanocatalysts for recycling PET plastic waste using biomass-derived ethylene glycol
This work elucidated the effect of TiO2 morphology on the structure–activity properties of MnOx/TiO2 nanocatalysts toward developing practically feasible catalytic routes for the plastic recycling industry.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05373G

Inclusion of gold ions in tiara-like nickel hexanuclear nanoclusters
The inclusion properties of various metal ions in Ni6(PET)12 were investigated and it was found that it selectively includes gold ions.
Nanoscale, 2025,17, 3721-3727
https://doi.org/10.1039/D4NR04579C
Small-angle neutron scattering differentiates molecular-level structural models of nanoparticle interfaces
Small-angle neutron scattering can be utilized to distinguish structural models of nanoparticles with molecular- and Å-scale differences.
Nanoscale, 2025,17, 3798-3808
https://doi.org/10.1039/D4NR04365K
Stacked meshes with super-wettability via atmospheric plasma for efficient emulsion separation
An efficient emulsion separation strategy has been developed using multilayer stacked nylon meshes treated with atmospheric plasma with super-wettability.
Nanoscale, 2025,17, 3777-3786
https://doi.org/10.1039/D4NR04457F
A-site composition tuning in methylammonium-based metal halide perovskite colloidal nanocrystals
Methylammonium-based A-site composition tuning in lead halide perovskites via post-synthetic cross-ion exchange to generate phase-stable colloidal nanocrystals of FAxMA1−xPbI3 and CsxFAyMA1−x−yPbI3 (TCPbI3).
Nanoscale, 2025,17, 3787-3797
https://doi.org/10.1039/D4NR03422H
Ultra-confined plasmons reveal moiré patterns in twisted bilayer graphene–talc heterostructure
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR04532G
Self-Supporting Poly (3,4-ethylenedioxythiophene) and Fe3C Co-Decorated Electrospun Carbon Nanofibers as Li2S Supporter for Lithium Sulfur Batteries
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR04989F
Nano-spherical tip-based smoothing with minimal damage for 2D van der Waals heterostructures
Two-dimensional materials and their heterostructures have significant potential for future developments in materials science and optoelectronics due to their unique properties.
Nanoscale, 2025,17, 3095-3104
https://doi.org/10.1039/D4NR03583F
Construction of an Sc-NiFe-LDH electrocatalyst for highly efficient electrooxidation of 5-hydroxymethylfurfural at industrial current density
Sc-NiFe-LDH catalyzed electrooxidation of HMF to FDCA, achieving the FDCA faradic efficiency and selectivity of 96.5% and 99.5%, respectively, at a current density of >600 mA cm−2.
Nanoscale, 2025,17, 3114-3122
https://doi.org/10.1039/D4NR04389H
About this collection
Nanoscale is proud to present this themed collection highlighting 2025’s rising stars of nanoscience and nanotechnology research, which gathers the very best work from researchers in the early stages of their independent career.
Each contributor was recommended by experts in their fields for carrying out work with the potential to influence future directions in nanoscience and nanotechnology. Congratulations to all the featured researchers on their important work in the field so far!