Themed collection Biomaterials Science Open Access Spotlight

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Open Access Minireview

Non-viral mRNA delivery to the lungs

This review highlights emerging strategies for lung-targeted mRNA delivery using non-viral vehicles, describing advances in bioinspired design and nanoparticle engineering.

Graphical abstract: Non-viral mRNA delivery to the lungs
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Multifunctional bilayer dressings: a next generation biomaterial for enhanced wound healing

Extracellular matrix mimicking bilayer wound dressings, combining hydrogels and electrospun nanofibers, offer a biomimetic approach for moisture retention, antibacterial activity, and pro-healing features for enhanced skin regeneration.

Graphical abstract: Multifunctional bilayer dressings: a next generation biomaterial for enhanced wound healing
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Conductive and piezoelectric biomaterials: a comprehensive review of load-bearing soft tissue repair

This figure illustrates the role of electrical signals in load-bearing soft tissues. Leveraging conductive or piezoelectric biomaterials, the application of tissue engineering techniques for damage repair is explored (created with BioRender).

Graphical abstract: Conductive and piezoelectric biomaterials: a comprehensive review of load-bearing soft tissue repair
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Impact of culture vessel materials on biomanufacturing of dendritic cell-based immunotherapies in closed systems

This review presents a multifaceted overview of how the biomanufacturing context including culture vessels, media, engineered surfaces, and workflows impact monocyte-derived dendritic cells for clinical applications.

Graphical abstract: Impact of culture vessel materials on biomanufacturing of dendritic cell-based immunotherapies in closed systems
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy

(a) Two primary mechanisms for cross-presentation of internalized antigens: cytosolic and vacuolar pathways. (b) To enhance antigen presentation and generate T cell responses, glycans are multivalently presented on a range of nanocarrier systems.

Graphical abstract: Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Melatonin and the nervous system: nanomedicine perspectives

The potential of nanomaterials and nanocarriers to improve melatonin’s neurotherapeutic efficacy and targeted central nervous system delivery is highlighted in this review, which examines the intersection of melatonin research and nanomedicine.

Graphical abstract: Melatonin and the nervous system: nanomedicine perspectives
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication

This review introduces magnetic-based tissue engineering (MagTE) as an integrative approach that combines cell manipulation, remote stimulation, and maturation to streamline biofabrication and advance clinically relevant tissue constructs.

Graphical abstract: Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Tumor microenvironment modulation innovates combinative cancer therapy via a versatile graphene oxide nanosystem

Versatile graphene oxide nanomaterials enable tumor microenvironment (TME) modulation and TME-responsive drug delivery for combinative cancer therapy.

Graphical abstract: Tumor microenvironment modulation innovates combinative cancer therapy via a versatile graphene oxide nanosystem
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition

Optimizing the physicochemical properties of engineered bone implants enhances osseointegration and promotes bone regeneration by regulating the local immune responses.

Graphical abstract: Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Ultrasound-activated inorganic nanomaterials to generate ROS for antibacterial applications

This review discusses recent progress in inorganic nanomaterials that respond to ultrasound to generate reactive oxygen species (ROS) for antimicrobial applications, with the aim of inspiring the design of future novel antimicrobial agents.

Graphical abstract: Ultrasound-activated inorganic nanomaterials to generate ROS for antibacterial applications
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Polydopamine as a versatile optical indicator for colorimetric and fluorescence-based biosensing

This review provides a comprehensive overview of the advancements in the use of polydopamine-based materials for colorimetric and fluorescence-based biosensing.

Graphical abstract: Polydopamine as a versatile optical indicator for colorimetric and fluorescence-based biosensing
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Control and interplay of scaffold–biomolecule interactions applied to cartilage tissue engineering

Cartilage tissue engineering combines biomaterials, cells, and bioactive factors to create stable, functional neotissue. Scaffold-biomolecule interactions can be tuned to optimize tissue regeneration.

Graphical abstract: Control and interplay of scaffold–biomolecule interactions applied to cartilage tissue engineering
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases

This review summarizes naïve extracellular vesicles (EVs) in clinical trials for central nervous system (CNS) diseases and updates recent translational preclinical research on EV-loaded drugs or genes for CNS treatments.

Graphical abstract: Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Review Article

Biomaterial-based strategies for primary human corneal endothelial cells for therapeutic applications: from cell expansion to transplantable carrier

Biomaterial-based strategies, including ECM coatings and functionalized polymers, enable efficient expansion of primary human corneal endothelial cells, addressing donor shortages and advancing cell therapy for corneal transplantation.

Graphical abstract: Biomaterial-based strategies for primary human corneal endothelial cells for therapeutic applications: from cell expansion to transplantable carrier
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Communication

Plasma protein corona on silica nanoparticles enhances exocytosis

The influence of a pre-adsorbed human plasma protein corona on the exocytosis of silica nanoparticles (SiNP) is reported. SiNPs with a pre-adsorbed protein corona are exocytosed rapidly depending also on the composition of the adsorbed proteins.

Graphical abstract: Plasma protein corona on silica nanoparticles enhances exocytosis
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Biomimetic double network hydrogels of chondroitin sulfate and synthetic polypeptides for cartilage tissue engineering

Biomimetic double network hydrogels provide minimally invasive solution for treatment of cartilage defects.

Graphical abstract: Biomimetic double network hydrogels of chondroitin sulfate and synthetic polypeptides for cartilage tissue engineering
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Peptide hydrogels as slow-release formulations of protein therapeutics: case study of asparaginase-loaded hydrogels

An injectable peptide hydrogel was used for the sustained release of Erwinase®, an FDA-approved therapeutic enzyme against acute lymphoblastic leukemia.

Graphical abstract: Peptide hydrogels as slow-release formulations of protein therapeutics: case study of asparaginase-loaded hydrogels
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Antimicrobial cobaltocenium copolymers: tuning amphiphilicity against NDM-1 bacteria

Cationic metallopolymers offer a promising strategy to combat multidrug-resistant (MDR) Gram-negative bacteria.

Graphical abstract: Antimicrobial cobaltocenium copolymers: tuning amphiphilicity against NDM-1 bacteria
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Engineering a bacterial polysaccharide-based metal–organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing

Cu-BTC mofs embedded, tannic acid loaded 3-D polymeric hydrogel composed of gellan gum, zein for deep wound healing.

Graphical abstract: Engineering a bacterial polysaccharide-based metal–organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Fibroblast proximity to a tumor impacts fibroblast extracellular vesicles produced by 3D bioprinted stromal models

This study utilizes a 3D bioprinted stromal model to obtain EVs that differ based on proximity to a tumor. A 3D tumor spheroid model displayed increased spheroid diameter after treatment with normal tumor adjacent fibroblast EVs.

Graphical abstract: Fibroblast proximity to a tumor impacts fibroblast extracellular vesicles produced by 3D bioprinted stromal models
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Enhancing hand hygiene compliance through the long-lasting antimicrobial effects of nitric oxide-releasing hand sanitizer gel

This study developed a nitric oxide-releasing (NORel) hand sanitizer gel which demonstrated superior antimicrobial properties, achieving over 5-log reduction in bacteria, and maintained efficacy longer than commercial alcohol-based gels.

Graphical abstract: Enhancing hand hygiene compliance through the long-lasting antimicrobial effects of nitric oxide-releasing hand sanitizer gel
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Antimicrobial 3D printed gelatin scaffolds for root canal disinfection in regenerative endodontics procedures

3D printed gelatin scaffolds incorporated with quarternary ammonium compounds are a promising effective and cytocompatible platform for root canal disinfection in regenerative endodontic procedures (REPs).

Graphical abstract: Antimicrobial 3D printed gelatin scaffolds for root canal disinfection in regenerative endodontics procedures
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Multivalent 2D- and 3D-nanogels as carbohydrate-lectin binders

The development of synthetic glycoarchitectures for targeted bacterial adhesion represents a promising strategy in anti-adhesion therapy.

Graphical abstract: Multivalent 2D- and 3D-nanogels as carbohydrate-lectin binders
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Metabolic click-labeling of interleukin-10 enhances the immunomodulatory potential and wound healing properties of mesenchymal stem cell-derived extracellular nanovesicles

Integration of interleukin-10 to mesenchymal stem cell-derived extracellular nanovesicles effectively enhances anti-inflammatory responses in both macrophages and DCs, ultimately accelerating the skin wound healing in vivo.

Graphical abstract: Metabolic click-labeling of interleukin-10 enhances the immunomodulatory potential and wound healing properties of mesenchymal stem cell-derived extracellular nanovesicles
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Fabrication of uniform biodegradable microcages with predesigned shape printed from microarrays for sustained release of small hydrophilic molecules

A microprinting approach is developed to fabricate uniform polymer microcages from microarray structures, enabling scalable production and tunable drug release through precise control over polymer composition.

Graphical abstract: Fabrication of uniform biodegradable microcages with predesigned shape printed from microarrays for sustained release of small hydrophilic molecules
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

From saccharides to synthetics: exploring biomaterial scaffolds as cell transduction enhancers

Dry biomaterial scaffolds (Drydux) are a novel platform that enhances viral transduction ~10-fold while simplifying therapeutic cell production. Here, we systematically evaluate the biomaterial properties governing transduction enhancement.

Graphical abstract: From saccharides to synthetics: exploring biomaterial scaffolds as cell transduction enhancers
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Injectable and self-healable supramolecular hydrogels assembled by quaternised chitosan/alginate polyelectrolyte complexation for sustained drug delivery and cell encapsulation

Supramolecular hydrogels based on water-soluble quaternised chitosan/alginate polyelectrolyte complexes showed self-healing and injectable properties, a sustained release of bovine serum albumin, and enabled cell encapsulation at physiological pH.

Graphical abstract: Injectable and self-healable supramolecular hydrogels assembled by quaternised chitosan/alginate polyelectrolyte complexation for sustained drug delivery and cell encapsulation
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Development of a bioactive hyaluronic acid hydrogel functionalised with antimicrobial peptides for the treatment of chronic wounds

A bioactive hyaluronic acid hydrogel is developed by conjugation of gelatin and antimicrobial peptides.

Graphical abstract: Development of a bioactive hyaluronic acid hydrogel functionalised with antimicrobial peptides for the treatment of chronic wounds
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Biofunctionalization of electrospun silk scaffolds with perlecan for vascular tissue engineering

This study biofunctionalized silk grafts with domain V of human perlecan via linker-free plasma-based immobilization enhancing endothelial cell adhesion and angiogenesis while inhibiting smooth muscle proliferation—advancing vascular graft design.

Graphical abstract: Biofunctionalization of electrospun silk scaffolds with perlecan for vascular tissue engineering
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Theragenerative injectable bone-adhesive hydrogels for combined photothermal osteosarcoma therapy and bone repair

Injectable hydrogels with self-healing properties, tissue adhesion, biocompatibility, and cancer therapeutic capabilities offer a promising solution for addressing bone loss and residual tumor cells following surgical resection of osteosarcoma.

Graphical abstract: Theragenerative injectable bone-adhesive hydrogels for combined photothermal osteosarcoma therapy and bone repair
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Functionalization of viscoelastic gels with decellularized extracellular matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration

Viscoelastic gels are functionalized with decellularized ECM microparticles for tissue regeneration. This approach would be a powerful method because functional scaffolds with sufficient mechanical and biological properties facilitate tissue regeneration.

Graphical abstract: Functionalization of viscoelastic gels with decellularized extracellular matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Tunable hydrogel networks by varying secondary structures of hydrophilic peptoids provide viable 3D cell culture platforms for hMSCs

This study reports decoupled control of mechanics and network connectivity in 3D, cell-laden hydrogels crosslinked with water soluble peptoids of various secondary structures.

Graphical abstract: Tunable hydrogel networks by varying secondary structures of hydrophilic peptoids provide viable 3D cell culture platforms for hMSCs
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Biocompatible composite hydrogel with on-demand swelling-shrinking properties for 4D bioprinting

We engineered SwellMA by combining gelatin methacryloyl (GelMA) with sodium polyacrylate (SPA) to enable dynamic shape changes and enhanced performance in 4D bioprinting applications.

Graphical abstract: Biocompatible composite hydrogel with on-demand swelling-shrinking properties for 4D bioprinting
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Chondrogenic and chondroprotective response of composite collagen I/II-hyaluronic acid scaffolds within an inflammatory osteoarthritic environment

In osteoarthritic-like environments, cartilage formation was reduced and inflammatory response was higher, and including hyaluronic acid in hydrogels modulated this response.

Graphical abstract: Chondrogenic and chondroprotective response of composite collagen I/II-hyaluronic acid scaffolds within an inflammatory osteoarthritic environment
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Designed gramicidin-inspired stabilized peptide-based therapeutics to potentiate immunotherapy against aggressive kidney cancer

The designed ionophore, gramicidin-inspired protease-stabilized peptide-based proton transporter, exhibited strong anti-cancer efficacy against metastatic, radioresistant kidney cancer and potentiated immunotherapy.

Graphical abstract: Designed gramicidin-inspired stabilized peptide-based therapeutics to potentiate immunotherapy against aggressive kidney cancer
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Development of a nano-vaccine for high-grade serous ovarian cancer

An overview of the development of a vaccine for High-Grade Serous Carcinoma.

Graphical abstract: Development of a nano-vaccine for high-grade serous ovarian cancer
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

A study of saponin-encapsulated ultrasound microbubbles Rb3NPs@MBs for atherosclerosis targeted treatment

Here we developed a new drug for treatment of atherosclerosis. It can clear 1/3 area of the plaque area targeting the aortic arch within three weeks. It brings hope for the rapid treatment of atherosclerosis.

Graphical abstract: A study of saponin-encapsulated ultrasound microbubbles Rb3NPs@MBs for atherosclerosis targeted treatment
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Machine-learning-guided identification of protein secondary structures using spectral and structural descriptors

We demonstrated the implementation of a machine-learning-mediated approach to identify the secondary structures of proteins based on different spectral and structural descriptors.

Graphical abstract: Machine-learning-guided identification of protein secondary structures using spectral and structural descriptors
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Guiding vascular infiltration through architected GelMA/PEGDA hydrogels: an in vivo study of channel diameter, length, and complexity

Organ shortages for transplantation in the United States impact over 100 000 patients, with 17 dying daily due to the lack of available organs.

Graphical abstract: Guiding vascular infiltration through architected GelMA/PEGDA hydrogels: an in vivo study of channel diameter, length, and complexity
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Multilamellar hyaluronic acid-b-poly(lactic acid) polymersomes for pathology-responsive MRI enhancement

This study introduces a biocompatible, stimuli-responsive theranostic system with ultrasmall iron oxide nanoparticles (USPIONs) encapsulated within the hyaluronic acid-b-poly(lactic acid) (HA–PLA) polymersome membrane and a model protein in the core.

Graphical abstract: Multilamellar hyaluronic acid-b-poly(lactic acid) polymersomes for pathology-responsive MRI enhancement
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Using thiol–ene click chemistry to engineer 3D printed plasmonic hydrogel scaffolds for SERS biosensing

Identifying key physicochemical factors affecting SERS biosensing performance in 3D cell models using a library of thiol–ene photo-crosslinked plasmonic hydrogels.

Graphical abstract: Using thiol–ene click chemistry to engineer 3D printed plasmonic hydrogel scaffolds for SERS biosensing
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Leveraging microtopography to pattern multi-oriented muscle actuators

Simple templating of actuators via micro-topographical patterning (STAMP) enables precisely patterning muscle fibers within engineered tissues, enabling fabrication of complex multi-oriented architectures such as a biomimetic iris.

Graphical abstract: Leveraging microtopography to pattern multi-oriented muscle actuators
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Gradually-frozen aligned bacterial nanocellulose membranes loaded with gallic acid exhibit enhanced mechanical and dual antithrombotic-antimicrobial properties

Microstructurally aligned gradually-frozen bacterial nanocellulose is promising for biomedical applications. While BNC lacks antibacterial or antithrombotic activity, incorporating gallic acid and glycerol results in dual antifouling properties.

Graphical abstract: Gradually-frozen aligned bacterial nanocellulose membranes loaded with gallic acid exhibit enhanced mechanical and dual antithrombotic-antimicrobial properties
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Supervised machine learning for predicting drug release from acetalated dextran nanofibers

We present a novel machine learning workflow to assess in vitro drug release from electrospun Ace-DEX nanofibers. The model reliably predicts release across all scaffolds and demonstrates a drug-agnostic approach to cheracterize release rates.

Graphical abstract: Supervised machine learning for predicting drug release from acetalated dextran nanofibers
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Gelatin methacryloyl granular hydrogel scaffolds for skin wound healing

Gelatin methacryloyl (GelMA) granular hydrogel scaffolds (GHS) enhance cell infiltration, modulate inflammation, and improve the quality of skin tissue repair. These findings highlight the therapeutic potential of GelMA GHS for wound healing.

Graphical abstract: Gelatin methacryloyl granular hydrogel scaffolds for skin wound healing
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Long-term interleukin-4 release from 3D printable affinity hydrogels promotes M2-like macrophage polarisation in vitro

Localised cytokine delivery is a promising strategy for modulating immune response and enhancing regenerative medicine therapies. SPAK-PEGDA hydrogels enable the long-term controlled release of lysozyme and the sustained release of Interleukin-4.

Graphical abstract: Long-term interleukin-4 release from 3D printable affinity hydrogels promotes M2-like macrophage polarisation in vitro
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression

A microneedle patch (B/S-TM@MN) was developed to encapsulate ROS-responsive micelles loaded with berberine and sinomenine, which enhanced the overall anti-arthritis outcome through simultaneous anti-inflammation and anti-angiogenesis.

Graphical abstract: Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Graphical abstract: Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Self-targeted nanosystem for enhanced chemodynamic cancer therapy

A schematic illustration of ZnNP enhanced CDT for HGSOC. ZnNP promotes the tumor-specific generation of bioactive H2O2, which subsequently triggers ROS-dependent apoptotic cell death.

Graphical abstract: Self-targeted nanosystem for enhanced chemodynamic cancer therapy
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth

CMPs are tested for their potential as cellulase delivery system to degrade CNF in a controlled way. They release cellulase over 21 days and enable fibroblast growth in 3D as the nanocellulose hydrogel is slowly degraded compared to no or empty CMPs.

Graphical abstract: Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Rapid in situ forming PEG hydrogels for mucosal drug delivery

A rapid in situ-forming, mucoadhesive PEG hydrogel was developed, offering prolonged retention in the nasal cavity and potentially other mucosal sites for drug delivery applications.

Graphical abstract: Rapid in situ forming PEG hydrogels for mucosal drug delivery
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Enhanced in vitro transfection efficiency of mRNA-loaded polyplexes into natural killer cells through osmoregulation

The transfection efficiency of mRNA-loaded polyplexes was improved by treating NK cells with NaCl-mediated hypertonic culture media.

Graphical abstract: Enhanced in vitro transfection efficiency of mRNA-loaded polyplexes into natural killer cells through osmoregulation
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Oxidation-responsive, settable bone substitute composites for regenerating critically-sized bone defects

Traditionally used bone substitutes do not yield desired bone regeneration outcomes in critically-sized bone defects. Oxidation sensitive bone substitutes are an alternative that produce improved regeneration in large-scale bone defects.

Graphical abstract: Oxidation-responsive, settable bone substitute composites for regenerating critically-sized bone defects
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

An immunomodulatory encapsulation system to deliver human iPSC-derived dopaminergic neuron progenitors for Parkinson's disease treatment

A multi-component immunomodulatory encapsulation system has potential to improve the survival of therapeutic hiPSC-derived dopaminergic neuron progenitors, for the treatment of Parkinson’s disease.

Graphical abstract: An immunomodulatory encapsulation system to deliver human iPSC-derived dopaminergic neuron progenitors for Parkinson's disease treatment
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications

Schematic showing the development of the multifaceted VEGF-activated scaffolds to promote pro-regenerative environments for chronic wound applications.

Graphical abstract: Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic sonication for collagen I mRNA delivery to human tendon progenitor stem cells

Graphical representation of the production of MSC-Hyb LNPs via microfluidic sonication. After simultaneous rapid mixing of both phases under 30 kHz and 50 W sonication, the MSC-Hyb LNPs were formed from synthetic lipids and EV-derived material.

Graphical abstract: Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic sonication for collagen I mRNA delivery to human tendon progenitor stem cells
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Site-specific photo-crosslinking in a double crossover DNA tile facilitated by squaraine dye aggregates: advancing thermally stable and uniform DNA nanostructures

We investigated the role of dichloro-squaraine (SQ) dye aggregates in facilitating thymine–thymine interstrand photo-crosslinking of double crossover (DX) tiles to improve the thermal and structural stability of two-dimension DNA-based nanostructures.

Graphical abstract: Site-specific photo-crosslinking in a double crossover DNA tile facilitated by squaraine dye aggregates: advancing thermally stable and uniform DNA nanostructures
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Antimicrobial and anti-inflammatory effects of polyethyleneimine-modified polydopamine nanoparticles on a burn-injured skin model

PDNP–PEI targets S. epidermidis in planktonic and biofilm forms, enabling laser-activated eradication, while in a 3D burn model, it reduces inflammatory cytokines, scavenges ROS, and promotes healing.

Graphical abstract: Antimicrobial and anti-inflammatory effects of polyethyleneimine-modified polydopamine nanoparticles on a burn-injured skin model
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Effective cell sheet preparation using thermoresponsive polymer brushes with various graft densities and chain lengths

Thermoresponsive polymer brushes with various chain lengths and densities were prepared via silanization and subsequent ATRP. Appropriate PNIPAAm brush length and density conditions for various types of cell sheet fabrication were investigated.

Graphical abstract: Effective cell sheet preparation using thermoresponsive polymer brushes with various graft densities and chain lengths
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model

A thermoresponsive hydrogel is synthesised with biodegradability, in situ swelling, and drug release appropriate for anti-cancer agents. We demonstrate retention of the new hydrogel in vivo enabling local drug release in a pancreatic cancer model.

Graphical abstract: Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology

Fibrosis, a hallmark of chronic lung disease, involves ECM remodeling. This work shows that decellularized ECM from IPF lungs—with its unique biochemical composition—can promote a profibrotic lung fibroblast phenotype.

Graphical abstract: Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Hollow nanosystem-boosting synergistic effects between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia

Nanomedicine-based photothermal therapy (PTT) has been considered as an excellent alternative for treatment of tumor tissue due to its high therapeutic efficiency and controllable range.

Graphical abstract: Hollow nanosystem-boosting synergistic effects between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Enhanced combination therapy through tumor microenvironment-activated cellular uptake and ROS-sensitive drug release using a dual-sensitive nanogel

A facile approach for enhanced combination therapy using a low pH and NIR irradiation-dual sensitive nanogel.

Graphical abstract: Enhanced combination therapy through tumor microenvironment-activated cellular uptake and ROS-sensitive drug release using a dual-sensitive nanogel
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Matrix deformation and mechanotransduction as markers of breast cancer cell phenotype alteration at matrix interfaces

Change in pore sizes at matrix interfaces induces asymmetric cell contraction and disruption of nuclear mechanotransduction of breast cancer cells.

Graphical abstract: Matrix deformation and mechanotransduction as markers of breast cancer cell phenotype alteration at matrix interfaces
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Crosslink strength governs yielding behavior in dynamically crosslinked hydrogels

Injectable hydrogels have spawned great interest as vehicles for cell therapy. We find that crosslink strength controls the solid-to-liquid yielding transition; further, stronger crosslinks lead to brittle yielding, reducing injected cell viability.

Graphical abstract: Crosslink strength governs yielding behavior in dynamically crosslinked hydrogels
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Color-coded galectin fusion proteins as novel tools in biomaterial science

This study introduces color-coded human galectins fused with SpyCatcher, SpyTag, and fluorescent proteins, demonstrating their binding properties, ECM-like structure formation, and microgel-based cancer cell targeting.

Graphical abstract: Color-coded galectin fusion proteins as novel tools in biomaterial science
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Recyclable 3D printable single network granular hydrogels

Spherical microgels can be conveniently direct ink written into granular hydrogels because of their rheological properties when jammed.

Graphical abstract: Recyclable 3D printable single network granular hydrogels
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer

Zwitterionic polymer PMPC was conjugated to a DNA aptamer to enhance its therapeutic efficacy in vivo, while minimizing the recognition by anti-PEG antibodies.

Graphical abstract: Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery

We have developed a straightforward strategy to tune the interaction strength of supramolecular polymer–nanoparticle hydrogels that provides customized properties for a variety of biomedical applications.

Graphical abstract: A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery
From the themed collection: Biomaterials Science Open Access Spotlight
Open Access Paper

3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model

Chondrogenic differentiation of mesenchymal stem cells (MSCs) within a three-dimensional (3D) environment can be guided to form cartilage-like tissue in vitro to generate cartilage grafts for implantation.

Graphical abstract: 3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model
From the themed collection: Biomaterials Science Open Access Spotlight
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