Themed collection Journal of Materials Chemistry B Most Popular Articles 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Renal fibrosis is the result of all chronic kidney diseases and is becoming a major global health hazard.

This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.

Over the past two decades, metal–organic frameworks (MOFs) have garnered substantial scientific interest across diverse fields, spanning gas storage, catalysis, biotechnology, and more.

A mitochondrial targeting copper dithiocarbamate induces intense immunogenic cuproptosis in cancer cells and macrophage M1 polarization. This emphasizes the potential of mitochondrial targeting cuproptosis inducers in cancer immunotherapy.

The biochemical complexity of a material determines the biological response of cells triggered by a cell-material interaction.

A bioelectronic mucus-on-a-chip model is developed to monitor intestinal mucus barrier properties. The effects of a mucolytic agent and biofilm formation are investigated, offering insights into gastrointestinal mucus and biofilm research.

Demonstration of transient coacervate droplets and programmable fibers was achieved by temporally regulating the pH of the solution through biocatalytic pH modulation.

Here we present a promising strategy to create hybrid, biomimetic supramolecular injectable hydrogels reinforced covalent crosslinked mesoporous silica nanoparticles for tissue engineering applications.

Fluorophobic effect enhances supramolecular microsegregation.

Multiplex immunochemistry for proteins examining neuronal structure or function in NeuN+ regions adjacent intracortical microelectrodes (MEA) more closely matched historic intracortical MEA recording performance than traditional IHC quantification.

BSe-B is a novel photosensitizer for photodynamic therapy using two-photon excitation, selectively targets cancer cell while sparing healthy tissue. It generates type-I reactive oxygen species and shows promise in diagnosis and treatment of cancer.

Dynamic polymer materials with improved mechanical properties can be obtained by introducing supramolecular interactions between the polymer chains as demonstrated here by introducing ureidopyrimidinone quadruple hydrogen bonding units in the side chains of polyacrylates.

Peptide hydrogels are gaining much interest as 3D cell-laden matrices for cell culture. Here, a tunable protocol based on a metal chelator is proposed to disassemble peptide hydrogels and extract living cells for downstream biological applications.

Tuning the hydrophobicity of di- and tri-block amphiphiles co-assembled into enzyme-responsive micelles controls the rate and timing of their mesophase transitions, essential for designing programmable polymeric systems with tailored functions.

The amphiphilic probe selectively exhibits flourescence response towards uric acid and phytic acid, enabling differentiation via distinct emission channels, allowing for low detection limits and on-site monitoring with pre-coated paper strips.

Conductive hydrogels patterned with a confocal laser can produce complex shapes that support neuronal growth for over 7 weeks.

The waste collagen fiber reinforced conductive organic hydrogel sensor (BPGC-Gly) is environmentally adaptable and multifunctional for multi-modal health monitoring via temperature, humidity, strain, pressure and bioelectrical signal acquisition.

SmartReservoirs (SRs) are novel drug-reservoirs for hydrogel-forming microneedles (HF-MNs). SRs improved rifampicin solubility and diffusion through the HF-matrix, thereby enhancing the transdermal permeation of the poorly soluble antibiotic.

SaRNA was formulated with six different polymer carriers to generate saRNA-polyplexes. After screening for transfection efficiency, compared to a lipid-based standard, the best performing ones were characterized in detail and administered to mice.

Thermoresponsive shape memory polymers prepared with tunable transition temperatures using star-PCL macromers of varying molecular weights, improving tissue safety for use in applications such as self-fitting bone scaffolds and self-expanding stents.

Schematic diagram of the preparation of the enzyme-responsive nanoplatform HA-CP@Fe₃O₄ and its application in the study of antibacterial infection in vivo.

Conductive hydrogel sensors have attracted attention for use in human motion monitoring detection, but integrating excellent biocompatibility, mechanical, self-adhesive, and self-healing properties, and high sensitivity into a hydrogel remains a challenge.

Lysine and fatty acid-tethered amphiphilic copolymers exhibited potent antibacterial activity against Gram-positive (B. subtilis) and Gram-negative (E. coli) bacteria with side chain degradability in the presence of an enzyme and pH.

The MTX@HMSN/CS-loaded MN patch exhibited enhanced and sustained anti-inflammatory effects against psoriasis with a continuous release of MTX.

Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability of hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.

A stimuli-responsive, injectable, and in situ-forming hydrogel with synergistic, self-healing, and on-demand drug-delivery and antibacterial properties.

Endogenous O₂ can be continuously generated by the catalysis of Ce in the lattice of CeO₂ to enhance ¹O₂ production via a type II PDT (energy transfer), and many other ROS (such as O₂⁻ and ·OH) can be produced via a type I PDT (electron transfer).

In situ nitric oxide generation from copper-containing hydrogel enhances anti-inflammatory, cell migration, and angiogenic processes for promoted wound healing.

The constructed ZnS–Ti₃C₂/PLLA scaffolds were able to release H₂S gas to disrupt biofilm and further remove bacteria through photothermal. In addition, the Zn²⁺ released from the composite scaffolds could promote osteogenic differentiation of BMSCs.