Themed collection 150th Anniversary Collection: Sensors for Human and Planetary Health

The creation of reagentless protein-based biosensors that are capable of monitoring molecular analytes directly in bodily fluids could revolutionize our understanding of biology and personalized health monitoring.

The research progress and applications of colorimetric sensors based on nanozymes with peroxidase-like activity.

In recent years, with the rapid development of electrochemiluminescence (ECL) sensors, more luminophores have been designed to achieve high-throughput and reliable analysis.

Fluorescent nanoparticle (FNP)-based dual-emission ratiometric fluorescent probes (DRFP) are summarized as hybrid FNPs, single FNPs with intrinsic dual emission and target-induced new emission, and DRFPs based on auxiliary nanomaterials.

Seeing is believing - and optical sensors (optodes) are ideal tools to make chemistry visible in real time. Find out how technological and chemical advances enable multiparameter imaging of complex samples.

Environmental protection and food safety are closely related to the healthy development of human society; there is an urgent need for relevant analytical methods to determine environmental pollutants and harmful substances in food.

Development of photoelectrochemical sensors interfaced with semiconductor quantum dots (QDs) as a promising approach for fabricating new photoelectrodes and photoelectrochemistry systems suitable for energy storage and biosensing applications.

Typical forms of a combination of electrowetting-on-dielectric (EWOD) technology with sensing and other microfluidic manipulation techniques are reviewed from a technical perspective, including the purposes, significance, and biomedical applications.

SERS for antibiotic resistance diagnosis.

Combining affinity-based nanoswitches with state-dependent readout platforms allows for continuous biosensing and acquisition of real-time information about biochemical processes occurring in the environment of interest.

A high-throughput tetraphenylethylene (TPE)-based fluorescent sensor array was constructed for the identification and detection of microorganisms.

Combining a CR1SPR/Cas12a assay integrated into a paper-based analytical device with a personal glucose meter signal readout results in a "sample-in–answer-out" nucleic acid quantification system.

Innovative for the scientific community and attracting attention in the extensive biomedical field are novel compact organic chemosensing systems built upon unique core molecular frameworks.

Label-free SERS salivary sensor platform based on hollow carbon nanofibers functionalized with silver nanoparticles (Ag@HCNFs) has been developed to monitor anomalous concentrations of salivary nitrite facilitating pre-diagnosis of oral cancer.

Aim: obtain a field-deployable portable box for the online detection of heavy metals in water through an automatable software-assisted procedure and square-wave anodic stripping voltammetry.

Electrospun CA NF-decorated PBSP electrochemical sensors can quickly and sensitively detect organic substances, proteins, and bacteria.

Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces.

An innovative disposable microfluidic device was designed, created, and mounted in a 3D-printed chassis to capture images. The images were processed using a custom detector which automatically identifies target glucose strips and colorimetric values.

Variations in the surface patterns of 3D printed electrochemical sensor can alter the analytical performance of the sensor for the detection of analytes.

Photopolymerization binds H⁺ ionophores covalently to poly(decyl methacrylate) sensing membranes of ion-selective electrodes. The membranes are at the same time covalently attached to the underlying inert polymer and the nanographite solid contact.

Ion-selective chemiresistive sensor platform for continuous monitoring over a wide concentration range, with low LOD, good response time, selectivity, reproducibility, and reversibility. The economical, simple devices don't need reference electrodes.

We report a photoluminescent and electrochemiluminescent Hg²⁺ probe based on the transmetalation reaction between Hg²⁺ and boronic acid of the ancillary ligand of a cyclometalated Ir(III) complex.

Bovine serum albumin (BSA) containing buffers are the standard blocking buffer in biosensing, yet different binding kinetics are observed with buffers containing human serum albumin (HSA) or human serum.

A pH-sensitive CQD thin film for the detection of dyes in various water resources.

Measurement of steady-state oxygen levels in a high-throughput organ-on-chip platform enabled rapid and non-invasive monitoring of dose and time-dependent injury responses of human kidney cells to cisplatin, a drug with toxic effects in the kidney.

FPNTs were synthesized to measure the temperature dynamically in in vitro 3D co-cultured tumor spheroids.

Hydrogen peroxide (H₂O₂) is involved in many important tasks in normal cell metabolism and signaling.

Ten DNA aptamers for tetracycline antibiotics studied using the intrinsic fluorescence. Using three of the aptamers, a sensor array is produced to discriminate tetracycline, oxytetracycline and doxycycline from each other and from other molecules.

Electrochemical aptamer-based sensors are the first molecular monitoring technology that support real-time measurements in the living body. Electrode placement plays a key role in the performance of these sensors when they are deployed for intravenous measurements.

A wide-range of trivial and non-trivial logic gates have been designed based on differential opto-chemical interactions of a single molecular probe.

Step-by-step development of the MIP-SPCE sensor to determine insulin.

A multivalent DNA walker amplification biosensor combined with the microfluidic chip for simultaneously and sensitively detecting V.P, S.T, and S.A bacteria.

A molecularly imprinted ratiometric fluorescence sensor for the sensitive detection of microcystins in environmental water.

A dual assay cartridge was developed and used in conjunction with a handheld reader for sensing % glycated albumin to monitor gestational diabetes at home.

Ion-selective membrane modified paper substrates were used to control the unfavourable super-Nernstian response of Pb²⁺-ISEs when coupled with microfluidic paper-based solution sampling.

A bacteria-imprinted polythiophene film (BIF)-based impedimetric sensor was proposed for the rapid and sensitive detection of S. aureus. A significant improvement is the reduced time for both BIF fabrication (15 min) and bacterial capturing (10 min).

A fluorescent probe for detecting extracellular ATP.

Rapid, simple, inexpensive, accurate and sensitive point-of-care (POC) detection of viral pathogens in bodily fluids is a vital component of controlling the spread of infectious diseases.

Early determination of blood lactate levels may accelerate the detection of sepsis, one of the most time-sensitive illnesses.

A novel AIE fluorescent probe BTD was developed for the monitoring of Al³⁺, along with high sensitivity and high selectivity. This probe was successfully applied to the sensing of Al³⁺ in living cells and zebrafish.

We present an SPR-based antigen detection method capable of detecting SARS-CoV-2 via spike S1 protein by a sandwiched amplification strategy based on a Ti₃C₂-MXene modified sensing platform and PDA–AgNPs–Ab₂ response signal amplifiers.

Using a ratiometric probe as the reporter for the CRISPR-Cas12a based biosensing system, the change of two fluorescence intensities can be monitored, while the TaqMan probe appears only one signal.

A schematic illustration of the synthesis of G-CDs and cell imaging under one-photon and two-photon conditions.

We have designed a single-particle detection assay for quantifying Hg²⁺ by DFM-correlated Raman spectroscopy. A tetrahedral DNA-directed core-satellite nanostructure is used as the SERS probe.

An ultrasensitive nonlinear hybridization chain reaction signal amplification fluorescence assay for the detection of small extracellular vesicles.

An electrochemiluminescence sensor for total bacterial count detection based on sulfur quantum dots with β-nicotinamide adenine dinucleotide as an important parameter.

A dual tuneable flow resistive pulse sensor which utilises additively manufactured parts. The sensor allows parts to be easily changed, washed and cleaned, its simplicity and versatility allow components from existing nanopore techniques to be integrated into a single device.

MIP films were used for the development of aflatoxin B1-selective sensor. The amplification of the sensor response was achieved due to Ag-nanoparticles in their structure. The linear dynamic range of the MIP sensor is 0.3–25 ng mL⁻¹.

Small-sized DNA fragments were converted into relatively large DNA tetrahedrons based on the CRISPR-Cas12a technology. This conversion approach enlarged the signal of small targets, make it easier and more reproducible for glassy nanopores to detect.

A smart signal conversion and amplification strategy based on silver–gold–silica core-satellite structure nanoparticles to sensitively SERS detect vitamin E.

A microfiber sensor detecting Ni²⁺ based on ion imprinting technology was fabricated and the sensor possessed high sensitivity, a low limit of detection and good regeneration.