Themed collection Celebrating the 100th birthday of Professor Sukh Dev

Harry Kochat, J. S. Yadav, Vinod K. Singh and S. S. V. Ramasastry introduce the special Organic & Biomolecular Chemistry themed collection celebrating the 100th birthday of Professor Sukh Dev.

Thapsigargin, a sesquiterpene lactone, has been known to the practitioners of traditional medicines as a cure for rheumatic pain and female infertility. This review discusses synthetic approaches and total syntheses of thapsigargin reported to date.

This review article presents a comprehensive overview of the latest progress in utilizing gem-difluoroallenes for selective additions, defluorination, as well as cycloaddition and cyclization reactions.

This review summarizes the progress made in the area of synergistic catalysis with N-heterocyclic carbenes and palladium.

The current landscape of synthetic campaigns and drug discovery initiatives focused on human microbiome-derived natural products is presented.

This research article highlights PIFA's versatility in organic synthesis, emphasizing its role in enabling diverse reactions and promoting its eco-friendly attributes over heavy transition metals.

This review highlights recent advancements in the synthesis of various quinoline derivatives through a multi-component approach involving different types of catalysts and catalyst-free reactions.

Vinyl cyclopropane scaffolds were synthesized via a proline-catalysed multicomponent reaction involving vinyl sulfoxonium ylides, aldehydes, and indane 1,3-dione.

A HMPA–water mediated protocol to access substituted-indenones through an oxygenative carbocyclization of 2-alkynylphenyl-substituted p-quinone methides has been developed under metal- and base-free conditions.

Novel enal-azomethine ylides derived from diazoenals and N-alkyl imines gave N-alkyl-3-formyl pyrroles. The new methodology was used in the short synthesis of biologically relevant pyrrolo[3,2-c]quinoline and pyrrolo[2,1-a]isoquinoline scaffolds.

Phosphine promotes a one-pot intramolecular Rauhut–Currier/Wittig reaction cascade to deliver arene- and heteroarene-fused diquinanes. The method is quite general and its utility has been demonstrated through various post-synthetic modifications.

Depending on the alkynyl-substitution, N-alkynyl aminols gave divergent outcomes of morpholines and 1,2-oxazepanes via reductive etherification. Further, the method was used for the total synthesis of the fungicides tridemorph and fenpropimorph.

The utilization of InCl₃·4H₂O as a mediator in the crucial step represents a novel procedure, particularly in prenylated systems, resulting primarily in the formation of a tertiary alcohol.

A photocatalytic route towards 2-trifluoroethylated and 2-perfluoroalkylated indoles is reported. This transition-metal-free protocol employs simple fluoroalkyl halide precursors and works under mild conditions.

A practical and straightforward protocol to access trifluoromethylated/perfluoroalkylated heteroarenes via radical-type nucleophilic substitution rather than typical radical-type electrophilic substitution is described here.

The first and concise syntheses of the anticancer agent diplofuranone A and the fatty acid-derived metabolite diapolic acid A have been demonstrated using easily accessible and commercially available starting materials.

We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)₂/HFIP as the excellent promoter system.

An efficient protocol for constructing polycyclic bridged chromano-furopyranones and pyrano-furopyranones (related to bioactive natural products) via bismuth(III)-catalyzed cascade annulation of hydroxy-pyranones and unsaturated γ-ketoesters is presented.

NMR spectral and theoretical analyses of homologous prolyl carbamates reveal subtle charge transfer tetrel bonding interactions (TBIs), selectively stabilizing their cisPro rotamers.

The combination of benzylamine, potassium tert-butoxide and 18-crown-6 acts as an excellent catalytic medium for the C–H arylation of arenes or heteroarenes with aryl or heteroaryl iodides/bromides under heating or light irradiation.

We have developed an easily scalable chromogenic probe for the dual-mode sensing of Spilosoma obliqua Nuclear polyhedrosis viruses (SpobNPV) in aqueous media.

An organophotocatalytic approach for the site-selective sulfonylation of C(sp²)–H bonds of anilide and quinoline amide derivatives utilizing aryl sulfonyl chlorides as a sulfonylating agent is developed.

A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed, synthesized and evaluated.

Herein, we present a general approach involving a sequential relay ring-closing enyne metathesis, Diels–Alder, and oxidative aromatization reactions to synthesize pluramycinone-sugar hybrids.

Palladium-catalyzed chalcogenation of benzoxazines has been achieved. The reaction shows broad substrate scope and late-stage functionalization potential. The regioselective product formation occurrs through a palladacycle.

Base-promoted oxidative annulation of 2-naphthols and phenylglyoxal monohydrate via a metal-free, visible light-mediated reaction is reported for the synthesis of hydroxy-naphthofuranone, naphthofuranone, and naphthofuran with a broad substrate scope.

The reaction between a-diazocarboxylates and trialkylphosphites under thermal and photochemical conditions results into N–P and C–P bond formation, respectively. The diazo substrates act as electrophiles in the former case and as carbene precursors in the later case.

This work demonstrates trivalent tris-(3-N-methyl-N-pyridyl propyl)amine catalyzing the site-selective mono-O-acylation of glycopyranosides.

A bisindole-based transmembrane anion antiporter, selectively toxic to the MCF-7 cancer cells, where chloride transport-induced homeostasis disruption triggered mitochondrial membrane depolarization, ROS generation, and lysosomal deacidification.

This research marks a significant step forward, offering rare dual-emissive nucleosides with excellent quantum yields and Stokes shift values, filling a critical gap in the field of nucleoside chemistry.

Access to spiro-α-iodo-γ-lactones via multidirectional consecutive double 5-exo-dig cyclization.

Naturally occurring sesquiterpenes having humulane frameworks are structurally intriguing and possess significant biological profiles.

A one-pot thiol-Michael strategy was developed for the construction of diverse β-thiophene-fused 5,10,15,20-tetraarylporphyrins. These new porphyrins displayed a modest red-shifted electronic absorption in contrast to meso-tetraarylporphyrins.

A viable protocol to access furo[3,2-c]chromen-4-ones engaging 4-hydroxy coumarins and thioamides and mediated by phenyliodine(III) diacetate at room temperature in a highly efficient manner is developed.

Computationally revealed mechanistic pathway of one-pot telescopically approached thiazetidine synthesis revealed the formation of a single product. The position of alkyl substitution plays significant role to enhance biomolecular interactions.

One-pot, four component thioalkenylation of donor–acceptor (D–A) cyclopropanes using in situ generated dithiocarbamates and propiolates catalyzed by Yb(OTf)₃ is presented.

We have established an in situ generated sulfonium-ylide mediated annulation to construct 2,3-disubstituted-2,3-dihydroindoles and extended to construct dihydrobenzofurans.

A simple two-step dialkylation protocol was developed to synthesize antibiotics photopyrones, pseudopyronines, and violapyrones from triacetate lactone in excellent yields.

The regioselective ring-opening of aryl oxiranes was investigated with various 4-hydroxycoumarins in dimethyl sulfoxide in the presence of 20 mol% FeCl₃ as a catalyst at 110 °C.